Nature Search

Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis

This study identifies a unique multiple sclerosis lesion, the broad rim lesion, which is associated with rapid disease progression and marked by a distinct inflammatory profile involving innate inflammation, cellular stress, unfolded protein response and apoptosis.

Luisa Klotz
Joost Smolders
Tanja Kuhlmann
ResearchOpen Access29 Apr 2025
Nature Medicine

Volume: 31, P: 2016-2026
Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing

Analyzing clinical records from a cohort of 3,042 donors in the Netherlands Brain Bank, natural language processing models unveil the symptomatology and potential misdiagnoses of a broad range of neurodegenerative disorders.

Nienke J. Mekkes
Minke Groot
Inge R. Holtman
ResearchOpen Access12 Mar 2024
Nature Medicine

Volume: 30, P: 1143-1153
Profiling of microglia nodules in multiple sclerosis reveals propensity for lesion formation

Microglia nodules are associated with brain pathology. Here, the authors show demyelination in microglia nodules in multiple sclerosis (MS), likely due to oxidized phospholipid phagocytosis and immune activation, suggesting that nodules could be involved in MS lesion formation.

Aletta M. R. van den Bosch
Marlijn van der Poel
Jörg Hamann
ResearchOpen Access23 Feb 2024
Nature Communications

Volume: 15, P: 1-16
Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

It is unclear if early pathological changes in normal-appearing multiple sclerosis (MS) tissue are reflected by molecular changes in microglia, which might contribute to lesion initiation. Here, authors demonstrate significant intrinsic differences in the human microglial transcriptome between grey and white matter regions, isolated from MS and non-neurological control donors, and show early microglial changes related to MS pathology.

Marlijn van der Poel
Thomas Ulas
Inge Huitinga
ResearchOpen Access13 Mar 2019
Nature Communications

Volume: 10, P: 1-13
Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Efficient repair of demyelinated CNS lesions involves the resolution of inflammation and induction of remyelination. Berghoff et al. show that sterol synthesis in microglia is key to both processes, which can be supported by squalene therapy.

Stefan A. Berghoff
Lena Spieth
Gesine Saher
Research21 Dec 2020
Nature Neuroscience

Volume: 24, P: 47-60
Tissue-resident memory T cells populate the human brain

Tissue-resident immune cells are important for local protections from pathogens. Here the authors show that brain tissue-resident memory T cells (T_RM cells) can be further subsetted by CD103 expression, with higher CD103 correlates with increased chemokine receptor and exhaustion markers such as PD1 or CTLA4, but reduced differentiation markers.

Joost Smolders
Kirstin M. Heutinck
Jörg Hamann
ResearchOpen Access02 Nov 2018
Nature Communications

Volume: 9, P: 1-14
Locus for severity implicates CNS resilience in progression of multiple sclerosis

A genome-wide association study including 22,389 cases of multiple sclerosis finds an association with disease progression at the DYSF–ZNF638 and DNM3–PIGC loci and identifies a potential of higher educational attainment in slowing disease progression.

Adil Harroud
Pernilla Stridh
Kári Stefánsson
Research28 Jun 2023
Nature

Volume: 619, P: 323-331
Stress of Dying is not Suppressed by High-dose Morphine or by Dementia

Zeynel A Erkut
Tamira Klooker
Dick F Swaab
Research03 Sept 2003
Neuropsychopharmacology

Volume: 29, P: 152-157
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

Microglia are the macrophages of the CNS, with innate neuroimmune function, and play important roles in tissue homeostasis, CNS development and neurodegeneration. Here human microglial gene expression profiles were generated. Human and mouse microglia were highly similar, except for aging-regulated genes, indicating that microglial aging differs between humans and mice.

Thais F Galatro
Inge R Holtman
Bart J L Eggen
Research03 Jul 2017
Nature Neuroscience

Volume: 20, P: 1162-1171
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Amendments and CorrectionsOpen Access17 Mar 2021
Nature

Volume: 592, P: E8
LifeTime and improving European healthcare through cell-based interceptive medicine

The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Reviews07 Sept 2020
Nature

Volume: 587, P: 377-386

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