Search

SCIFER detects clonal selection in whole-genome sequencing data using a population genetics model. Applied to a range of somatic tissues, SCIFER quantifies stem cell dynamics and infers clonal ages and sizes without requiring knowledge of driver events.

Cellular exhaustion can limit the ability of immune cells to control tumors. Here the authors show that expression of the transcription factor Irf4 marks NK cell percursors that will go on to become exhausted mature NK cells and identify targets to interfere with this trajectory to enhance control over melanoma metastasis.

Foetal haematopoiesis takes place in the liver before the bone marrow is seeded. Here the authors used imaging analysis and mouse genetics to look at nascent bone marrow formation and show that yolk-sac-derived myeloid cells promote haematopoiesis by promoting specification of a VCAM1⁺ sinusoidal colonisation niche.

The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.

Here, the authors show how in β-thalassemia, a perturbed bone marrow microenvironment leads to altered hematopoiesis. Reduced TGFβ reduces autophagy levels, in turn reducing dormancy and priming of haematopoietic stem cells and multipotent progenitors towards erythroid lineage.

Mammary gland resident macrophages are known to be crucial components of the mammary stem cell niche. Here, the authors show that CXCR4⁺ macrophages form a niche that regulates the tumor-initiating activity of breast cancer cells and induces early immune evasion through the recruitment of regulatory T cells.

Multiomic analysis of blast-phase myeloproliferative neoplasms identifies a chromosome 21 amplicon harboring DYRK1A as a clonal and therapeutically targetable event in around a quarter of cases.

Spatially segregated rRNA processing dictates nucleolar morphology and drives outward progression of pre-ribosomal RNA through nucleolar phases.

Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage colony-stimulating factor signaling and resulted macropinocytosis with the downstream, potentially IRF8-mediated genetic program to bias progenitor differentiation to neutrophil instead of TRM.

The morphogenetic events that occur during gastrulation involve dramatic cell- and tissue-level changes. Here they show that propagation of nematic order, leading to long-range spatial correlation, is universally conserved during metazoan embryogenesis.

Previous ophthalmic foundation models have struggled to generalize effectively to diverse and rare fundus diseases, restricting their clinical applicability. Here, the authors introduce a vision-language foundation model that demonstrates superior performance in diagnosing both common and rare fundus conditions.

To remain functional throughout life, neuronal cells must maintain the ability to synthesize and release specific neurotransmitters. Here, the authors show that this ability critically depends on the activity of Hox proteins.

C elegans is a model organism for life span research, and mitochondrial translation has been identified as a key process affecting longevity. Here authors show that the previously identified proteostasis is not the only mechanism that defines longevity induced by mitochondrial translation inhibition, but also C32E8.9-induced lipid remodelling and immune responses.

The conserved surface polysaccharide poly-β-(1,6)-N-acetyl-D-glucosamine (PNAG) is a promising vaccine target but antibodies raised against PNAG have shown restricted efficacy. Here, the authors describe an effective n + 2 glycosylation strategy, with control over the degree of N-acetylation, that allows the iterative assembly of partially and fully deacetylated PNAG glycans and investigate their potential as vaccine candidates.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Mutational signature analysis of blood cells isolated from 23 chemotherapy-exposed samples and 9 nonexposed controls characterizes the effects of various drugs on mutational burden, signature exposure and cell types.

High-resolution satellite data enables a unique verification of national methane emissions worldwide. Global estimates are 63 Tg a⁻¹ for oil-gas, 30% higher than the UNFCCC reports due to under-reporting by four largest emitters, and 33 Tg a⁻¹ for coal, consistent with previous estimates.

Cellular damage promotes sleep in C. elegans via Epidermal Growth Factor Receptors in sleep-promoting neurons, but the ligand was unknown. Here, the authors identify an EGFR ligand that is shed from damaged tissues by the protease ADM-4/ADAM17 to promote sleep.

Identifying an immunologic marker as a correlate of protection (CoP) for RSV vaccination is important. Here, the authors demonstrate RSV neutralizing antibodies and RSV prefusion IgG binding antibodies as CoP for mRNA vaccination against RSV disease.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Robbins and colleagues show that cigarette smoke-induced endothelial dysfunction enables atherosclerotic plaque macrophages to drive abdominal aortic aneurysm formation in a mouse model of atherosclerosis.

Developmental expression of the microRNA let-7 is tightly regulated in many animals, and turnover has been linked to LIN-28 and uridylation in mammals. This regulation is now shown to be conserved in Caenorhabditis elegans, and PUP-2 is shown to be a uridylase that is specifically recruited to let-7 in a LIN-28–dependent manner.

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance in multiple worm disease models, extending healthspan.

Here the authors unveil the essential role of MCL-1 for adult hair follicle regeneration and inhibition of proliferation stress-induced apoptosis in mice. They also identify a P53/MCL-1/BAK axis balancing proliferation and death of activated hair follicle stem cells to ensure proper hair growth.

Metformin may serve as a non-toxic intervention to inhibit mitochondrial metabolism and slow DNMT3A-R882 clonal haematopoiesis expansion, thus delaying or averting progression to acute myeloid leukaemia.

Antigen escape relapse remains a major obstacle when treating B-cell malignancies with immunotherapies. Here, the authors show that IKAROS regulates the surface expression of CD19 and CD22, revealing a mechanism by which B-cell cancers evade targeted immunotherapies.

A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.

ACTA2 p.R179 variants cause pediatric strokes due to moyamoya disease (MMD)-like occlusions. Here, the authors show that Acta2^R179C/+ smooth muscle cells are immature, causing MMD-like lesions that are reversed by altering cellular metabolism.

Guppy colouration is a very diverse trait under natural and sexual selection. Using a combination of high-resolution phenotyping and genomic analysis, the authors reveal the genetic architecture of this complex trait.

The estimation of low energies of many-body systems is a cornerstone of the computational quantum sciences. This paper demonstrates on a superconducting quantum processor that the Krylov quantum diagonalization algorithm is poised to complement its classical counterparts at the foundation of computational methods for quantum systems.

NiFe-based hydroxides are well-known for alkaline water oxidation but face efficiency issues due to unclear Fe dynamics. Here, the authors report that surface Fe dynamics are affected by Fe diffusion on the counter electrode and have developed a zinc-templated precursor to stabilize active Fe sites.

A gold catalyst supported on intergrown titanosilicate zeolites enhances propene oxide production by activating oxygen-transfer intermediates more efficiently at Ti interface sites.

DeepRETStroke is a deep learning system using retinal photographs to detect silent brain infarction and predict future stroke events.

Insights into the dogrose genome and centromeres explain their ability to achieve stable sexual reproduction.

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

A microfluidic-based system enables fast screening of Mycobacterium tuberculosis infection through analysis of specific T-cell responses.

The collapse of tropical forests during the Permian–Triassic Mass Extinction weakened carbon sequestration, sustaining high CO2 and extreme global warmth for millions of years: an example of a runaway feedback in Earth’s climate-carbon system.

Familial adenomatous polyposis (FAP) is an inherited gastrointestinal syndrome associated with duodenal adenoma formation. Here the authors show that IL17A-producing NKp44- group 3 innate lymphoid cells accumulate in FAP duodenal tissue and are associated with duodenal adenoma formation in patients with FAP.

How morphogen gradients induce complex gene expression programmes in the receiving cells is poorly understood. Here the authors use a quantitative approach to show that inC. elegansvulva induction cells control morphogen-induced gene expression by changing their sensitivity to the morphogen.

An RNA-binding protein on leukemia cells provides an effective target in mouse models.

Efficient sunlight-to-fuel conversion requires materials that produce long-lived charges, but increasing carrier lifetimes in visible-light-active photocatalysts has proven difficult. Now it has been shown that rapid charge deactivation via metal-centred states prevents long lifetimes and limits photocatalytic performance. These insights bridge solid-state and molecular photochemistry, informing strategies for improved photocatalyst design.

The authors show that aberrant epithelial GREM1 expression remodels intestinal stroma to form ectopic stem cell niches in mice. Anti-GREM1 reversed these changes, highlighting a potential strategy for preventing polyposis in patients with HMPS.

The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.