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Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Analysis combining multiple global tree databases reveals that whether a ___location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Polluted plants from constructed wetlands are considered unusable waste. Here, authors present a cost-effective, sustainable, scalable, nature-based method that eliminates micropollutants and transforms this waste into phytoprotective and biostimulant liquid fertilizers for agriculture.

Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

Symbiosis of nitrogen-fixing bacteria in evolutionarily novel “nodules” of diverse flowering plants including legume crops was assembled from pre-existing functions. Testing hypotheses of single vs. multiple origins is the focus of this Perspective.

The Mass Spectrometry Query Language (MassQL) is an open-source language that enables instrument-independent searching across mass spectrometry data for complex patterns of interest via concise and expressive queries without the need for programming skills.

Shocked compression experiments support the melt line of nickel above that of iron, as recently theorised, which helps to constrain the behavior of nickel at conditions relevant to Earth’s core where it makes up 5-20 wt %

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Hansen et al. used in vivo functional imaging of the human brainstem and cortex to demonstrate how the brainstem shapes cortical functional architecture, including oscillatory dynamics, cognitive specialization and hierarchical organization.

The authors observe THz emission from Ni/Pt heterostructure due to long-range ballistic orbital transport. The velocity of orbital current can be optically tuned by laser fluence, opening the avenue for future optorbitronic devices.

Using a genome-wide CRISPR knock-out screen, the authors defined the repertoire of genes that are required for proerythroblast survival and for terminal erythroid differentiation.

RMC-7977, a multi-selective RAS(ON) inhibitor, exhibits potent tumour-selective activity in multiple pre-clinical models of pancreatic ductal adenocarcinoma through a combination of pharmacology and oncogene dependence.

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Wood density is an important plant trait. Data from 1.1 million forest inventory plots and 10,703 tree species show a latitudinal gradient in wood density, with temperature and soil moisture explaining variation at the global scale and disturbance also having a role at the local level.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Dense calcium imaging combined with co-registered high-resolution electron microscopy reconstruction of the brain of the same mouse provide a functional connectomics map of tens of thousands of neurons of a region of the primary cortex and higher visual areas.

Food systems are increasingly globalized and interdependent. Using food supply data from over 170 countries, Bentham et al. characterize global patterns of food supply change over five decades, highlighting the decline in the supply of animal source food and sugar in many Western countries, the increase in the supply of such foods in Asian countries and remarkably little change in food supply in the sub-Saharan Africa region.

Unconventional unidirectional magnetoresistance observed in the heterostructures of a topological semimetal (WTe₂) and a magnetic insulator (Cr₂Ge₂Te₆) enables the electrical read-out of the magnetic states of a perpendicularly polarized magnet through longitudinal resistance measurements.

A study of SARS-CoV-2 variants examining their transmission, infectivity, and potential resistance to therapies provides insights into the biology of the Delta variant and its role in the global pandemic.

Clarke, Hawkinson and colleagues study the contribution of glycogen accumulation in the onset and progression of lung cancer.

Preclinical studies indicate that simultaneous HER2 and VEGF blockade may be beneficial in gastroesophageal adenocarcinoma (GEA). Here, the authors report the efficacy and biomarker analysis of a phase II clinical trial investigating the combination of bevacizumab (anti-VEGF) and standard-of-care CAPOX (capecitabine, oxaliplatin) and trastuzumab in previously untreated advanced HER2 + GEA.

Solid organ transplant recipients are at increased risk of infectious disease and have unique molecular pathophysiology. Here the authors use host-microbe profiling to assess SARS-CoV-2 infection and immunity in solid organ transplant recipients, showing enhanced viral abundance, impaired clearance, and increased expression of innate immunity genes.

Bhattacharjee and Schaeffer et al. map exclusive breastfeeding (EBF) in 94 low- and middle-income countries (LMICs), finding increased EBF practice and reduced subnational variation across the majority of LMICs from 2000 to 2018. However, only six LMICs will meet WHO’s target of ≥70% EBF by 2030 nationally, and only three will achieve this in all districts.

A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.

The authors analyse tree responses to an extreme heat and drought event across South America to understand long-term climate resistance. While no more sensitive to this than previous lesser events, forests in drier climates showed the greatest impacts and thus vulnerability to climate extremes.

Tiger numbers in India are starting to rebound after decades of being perilously low. This recovery offers lessons for conserving other rare animals.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

Metal halide perovskites have been studied as promising materials for blue light-emitting diodes (LEDs) but the stability is still a bottleneck. Here Wang et al. develop a chelating additive strategy to increase efficiency, operational stability and color stability of blue perovskite LEDs.