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Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer’s disease in 5xFAD mice

Gomez et al. show that boosting angiotensin-converting enzyme expression in microglia promotes phagocytic clearance of Aβ and endolysosomal trafficking, driven by spleen tyrosine kinase signaling in the 5xFAD transgenic model of Alzheimer’s disease.

Andrew R. Gomez
Hyae Ran Byun
Warren G. Tourtellotte
Research09 Jun 2025
Nature Aging

P: 1-15

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Boosting angiotensin-converting enzyme (ACE) in microglia protects against Alzheimer’s disease in 5xFAD mice

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