The outer membrane of Gram-negative bacteria contains many protein channels, called porins. These channels mediate the influx of various compounds, including antibiotics. Adaptations that reduce influx contribute to the emergence and dissemination of antibiotic resistance. This Review outlines recent advances in our understanding of the physico-chemical parameters that govern antibiotic translocation through porin channels.
- Jean-Marie Pagès
- Chloë E. James
- Mathias Winterhalter
