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Artificial intelligence-based detection of gastric cancer at different stages from noncontrast computed tomography is suggested to be feasible in a retrospective analysis of large and diverse cohorts, including real-world populations in opportunistic and targeted screening scenarios.

Sepsis can result in acute lung injury which may involve cross interaction via the gut-lung axis. Here the authors show γδ T17 cell migration from the gut to the lung in a murine model of sepsis and link IL-17A-mediated lung inflammation regulation by Wnt/β-catenin signaling in alveolar macrophages via CCL1.

Li et al. report ZnF₂ as the additive to balance shell growth rate of ZnSe in large InAs/InP/ZnSe/ZnS core-multishell quantum dots. An in-situ photo-crosslinking blended hole-transport layer is used to modulate the energy levels for balanced carrier dynamics in NIR LEDs, enabling peak efficiency of 20.5% and operational half-lifetime of 550 h at 50 W sr⁻¹ m⁻².

The molecular mechanisms underlying the function of different cellular states in glioblastoma stem cells (GSCs) remain poorly understood. Here, the authors perform integrated single cell and bulk analysis of GSCs and identify potential therapeutic targets.

The authors reprogram chicken fibroblast cells to form primordial germ cells (PGCs) in one species (black feather Langshan chicken) and then show such PGCs can be transplanted and migrate into the genital ridge of another chicken species (White Plymouth Rock) to produce viable offspring with the Characteristics of donor.

Sakuranetin is an important phytoalexin. The authors find that sakuranetin in rice attenuates endocytosis of effectors from the fungus Magnaporthe oryzae and enhances resistance against rice blast.

Cross-linked polymers with covalent adaptable networks are reprocessed under external stimuli at high temperatures which might deteriorate their performance. Here, the authors introduce carbon dioxide responsive ionic clusters into covalent adaptable polymer networks to facilitate the exchange of dynamic bonds providing materials with a rapid recycling and good mechanical performance.

Nestin can be localised in the nucleus of cancer cells, but its nuclear role in tumorigenesis is unclear. Here, the authors show that nuclear Nestin prevents senescence in tumor cells by stabilising lamin A/C from proteasomal degradation to maintain nuclear integrity.

Multi-omics data integration can be challenging in the event of cell heterogeneity. Here, the authors present scBridge, a method that exploits heterogeneous omics differences, to progressively integrate cells and narrows omics gap, leading to promising integration and label transfer results.

Loss of Nestin sensitizes non-small cell lung carcinoma (NSCLC) to oxidative stress. Here, the authors report a feedback loop between Nestin and Nrf2 wherein Nestin competes with Nrf2 for Keap1 binding, preventing Nrf2 degradation, and show the Nestin–Keap1–Nrf2 axis to regulate redox homeostasis in NSCLC.

Wheat production is threatened by wheat yellow mosaic virus (WYMV). Here, via genome-wide association study, the authors report that a putative methyltransferase B positively regulates WYMV infection through enhancing viral genomic RNA stability by N6-methyladenosine RNA modification.

This work reports a single-atom Ni incorporated CeO₂ catalyst that boosts the efficiency of solar CO₂ reduction under concentrated light irradiation.

METTL3 catalyzes mRNA m⁶A deposition. The authors identify an acetylation-mediated regulation of METTL3 subcellular localization and compartment-specific functions, a process that is fine-tuned by anti-inflammatory and pro-inflammatory signals, which ultimately determine breast cancer metastasis.

Ultra-fast optical time-___domain transformation (UO-TDT) techniques are used to encode spatial and spectral information from ultra-short pulses into the time ___domain. In this Primer, Zhang et al. cover the physical and mathematical basis of UO-TDT and its application in various imaging platforms, and conclude with an outlook on how these techniques could be applied to novel applications and imaging modalities.

Due to their challenging isolation, stannynes are underexplored and poorly understood. Now, a stannyne has been synthesized and isolated at room temperature using a bulky cyclic phosphino ligand, and it has been shown to exhibit the reactivity characteristics of carbenes, stannylenes and carbon–tin multiply bonded compounds.

The active sites of metal-free carbon catalysts for the oxygen reduction reaction remain still elusive. Now, Yao, Dai and co-workers combine work-function analyses with macro/micro-electrochemical measurements on highly oriented pyrolytic graphite and conclude that pentagon defects are the main active sites for acidic oxygen reduction.

Reactive school class closures have been widely implemented to mitigate COVID-19 outbreaks. Here, the authors show that, compared to symptom-prompted PCR testing, screening for cases in schools with antigen tests leads to greater reductions in infection rates in both students and the wider community.

Miniaturized energy storage devices integrated with wireless charging bring opportunities for next generation electronics. Here, authors report seamlessly integrated wireless charging micro-supercapacitors with high energy density capable of driving a model electrical car.

Iron deficiencies are a common non intestinal symptom seen in patients with irritable bowel disease. Here the authors show an associative link between microbiota assisted uptake of nutrients including iron and the promotion of immune tolerance in the intestine.

Pericytes play an essential role in blood brain barrier (BBB) integrity. Here, the authors generate pericyte-like cells (PCs) from human pluripotent stem cells (hPSCs) which display functional properties and also promote BBB recovery in a mouse model of cerebral artery occlusion.

The authors show that Preso1 acts as a scaffolding protein that binds mGluR, Homer and proline-directed kinases. Deletion of Preso1 prevents phosphorylation of mGluR at the Homer binding site and leads to an increase in mGluR5-dependent inflammatory pain.

The division of neural progenitors is closely regulated but how is unclear. Here, the authors show that mitotic kinesin KIF20A/MKLP2 interacts with a regulator of G protein signaling RGS3 in neural progenitor cells, dislodging it from the intercellular bridge of dividing cortical cells.

Regional-scale gravity fields can be evaluated using terrestrial gravity repeated measurements, according to a comparison between Gravity Recovery and Climate Experiment (GRACE) measurements and a time-variable terrestrial gravity model for North China