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A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promises to be a versatile brainsmatics tool for studying the whole brain at single-cell level.

Neural networks fundamentally dictate function. Here, the authors show thirteen uniquely connected neuron populations within the anterior thalamic nuclei, suggesting multiple parallel subnetworks support its emotional and cognitive functions.

Formation of a stable self-assembled monolayer for high-efficiency perovskite solar cells remains a challenge. Here uniform and stable SAM anchoring is achieved on a hydroxylated indium tin oxide surface, leading to highly efficient and stable perovskite solar cells.

The authors build a unified theoretical framework of black carbon mixing state and find a universal law, applicable in most climate/atmospheric chemistry models, which can greatly increase accuracy of black carbon climate effect estimation.

Research into the dynamics of chemical reactions at the single-molecule level is a pivotal undertaking. Here, the authors present a direct investigation of the chemiluminescent reaction dynamics of single molecules in solution, providing spatiotemporally resolved insights into chemical reactions.

Protein sequencing is one of the key aims of the nanopore field. Working toward this goal, here the authors report the direct identification of single amino acids in MoS₂ nanopores with sub-1 Dalton resolution, as well as the discrimination of the amino acid isomers and amino acid phosphorylation.

Optical imaging of single-molecule electrochemical reactions in aqueous solution enables super-resolution electrochemiluminescence microscopy, which can be used to monitor the adhesion dynamics of live cells with high spatiotemporal resolution.

While the list of van der Waals magnetic materials has expanded considerably over the last few years, these are still typically limited to low temperatures. Here, Wu et al report wafer scale growth, and robust room temperature ferromagnetism in Fe3GaTe2.

Engineering natural microbiomes for biotechnological applications remains challenging. Here, the authors present a combinatory top-down and bottom-up framework to engineer natural microbiomes for the construction of function-enhanced synthetic microbiomes.

Pyrochlore iridates have been studied for their potential to explore novel phases due to the interplay of correlations, spin-orbit interaction, and more recently dimensionality. Here the authors report a chiral spin-liquid-like state in (111)-oriented Y₂Ir₂O₇ thin films which emerges at a reduced thickness.

TFE3-translocation renal cell carcinoma (TFE3-tRCC) is a rare subtype of kidney cancer with no standard treatment options for the advanced disease. Here, the authors perform genomic and transcriptomic profiling of 63 untreated primary TFE3-tRCC tumours and reveal potential therapeutic targets.

An artificial ligament replacement is made from aligned carbon nanotubes formed into hierarchical helical fibres with nanometre and micrometre channels which are demonstrated for the replacement of anterior cruciate ligaments in both rabbit and ovine models, showing strong integration and functional recovery.

The efficient storage of high-energy gaseous fuels is problematic due to the risk of explosion. Here, the authors design and employ a metal-organic framework composed of Cu(II) and an octacarboxylate ligand, which is able to store acetylene in high density but at atmospheric pressure.

EY6A, a neutralizing antibody isolated from a patient convalescing from COVID-19, binds the receptor binding ___domain of the SARS-CoV-2 spike glycoprotein with high affinity, at a ___location away from the binding site for the ACE2 receptor, similar to the one recognized by CR3022.

Introduction of any interface will inevitably lead to a decrease in carrier mobility. Here, authors employ atomic layer deposition technology to construct composite phase interfaces, decoupling the interrelated thermoelectric parameters in n-type ZrNiSn materials.

Recurring climatic patterns can be used to predict severe winter particulate air pollution over North China, according to an analysis of wintertime particulate concentrations and atmospheric circulation.

The SARS-CoV-2 pandemic highlighted our need for methods that allow rapid viral surveillance. Here, authors report a wireless, battery-free and wearable self-diagnosis platform that can continuously capture viral particles, diagnose infection status and evaluate symptom severity via breath and blow.

Rev-erbα is a known regulator of the circadian clock. Here, the authors show that Rev-erbα is also a regulator of synaptic dysfunction in preclinical models of epilepsy.

The authors characterize the phonon modes at the FeSe/SrTiO₃ interface with atomically resolved electron energy loss spectroscopy and correlate them with accurate atomic structure in an electron microscope. They find several phonon modes highly localized at the interface, one of which engages in strong interactions with the electrons in FeSe.

An enhanced superconducting pairing temperature (T_g) has only been observed in single-layer FeSe interfaced with TiO_x system. Here, the authors construct a new interface composed of single-layer FeSe interfaced with LaFeO₃ showing a highest T_g of 80 K among all-known interfacial superconductors.

The identification of transcription factors (TFs) whose binding sites are affected by risk genetic variants remains crucial. Here, the authors develop a statistical framework to analyse ChIP-seq and GWAS data, identify 22 breast cancer risk-associated TFs and a core TF-transcriptional network for FOXA1 and co-factors.

Site-selective cross- and homo-hydrodimerization of terminal alkyl alkenes is a synthetic challenge. Now, a nickel-catalysed redox cross- and homo-hydrodimerization process is reported, providing selective access to linear alkyl–alkyl coupled products. Branched dimers can be formed by removing co-oxidant CuBr₂ from the reaction mixture.

While ferroelectric materials are promising candidates for solar water splitting, most examples show poor activities. Here, authors prepare charge-collecting nanostructures on the positive and negative domains of BaTiO₃ and demonstrate photocatalytic overall water splitting.

This study elucidates the potential of targeting FMO3 to modulate TMAO levels as a therapeutic approach for mitigating acute kidney injury and subsequent renal fibrosis.

In the summer of 2020, China experienced record rainfall and flooding. Here, the authors investigate the connection between the rainfall and the abrupt decrease in emissions due to Covid-19 and find that the emission decrease may have contributed to the rainfall.

Topoisomerases are thought to work in DNA, but not RNA, metabolism. Here Xu et al. describe that Top3A can also act as an RNA topoisomerase and find it in a complex with the fragile X syndrome protein FMRP and a binding partner of FMRP, Tudor ___domain–containing protein 3 (TDRD3), which together promote synapse formation in flies and mice. These data suggest that topoisomerases are needed for both DNA and RNA metabolism.

Direct CO₂ electroreduction on Cu-based catalysts has been used to produce C₂ products but yields of C₃ products have remained low. Here a CO₂ supersaturation strategy is used to promote electrodeposition of a highly alloyed CuAg electrode and its subsequent selectivity towards 2-propanol.

Rice false smut, caused by the pathogenic ascomycete fungus Ustilaginoidea virens (Cooke) Takah, has a significant economic impact on crop production. Here, Zhang et al. report the draft genome sequence of U. virensand provide insight into the evolution of genes involved in pathogenicity and adaptation to a biotrophic and floret-infecting lifestyle.