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2D quasi-layered material with domino structure

Interlayer coupling strength classifies 2D materials into layered and non-layered types. Here authors introduce the concept of quasi-layered domino-structured materials, the interlayer of which have a synergistic blend of vdW forces and covalent bonds.

Haihui Lan
Luyang Wang
Lei Fu
ResearchOpen Access09 Nov 2023
Nature Communications

Volume: 14, P: 1-7
Generic protein–ligand interaction scoring by integrating physical prior knowledge and data augmentation modelling

Machine learning can improve scoring methods to evaluate protein–ligand interactions, but achieving good generalization is an outstanding challenge. Cao et al. introduce EquiScore, which is based on a graph neural network that integrates physical knowledge and is shown to have robust capabilities when applied to unseen protein targets.

Duanhua Cao
Geng Chen
Mingyue Zheng
Research06 Jun 2024
Nature Machine Intelligence

Volume: 6, P: 688-700
Biosynthesis of triacsin featuring an N-hydroxytriazene pharmacophore

During the biosynthesis of triacsin, the two N–N bond formation reactions necessary to create the unique N-hydroxytriazene moiety are catalyzed by a glycine-utilizing hydrazine-forming enzyme and a nitrite-utilizing N-nitrosating enzyme.

Antonio Del Rio Flores
Frederick F. Twigg
Wenjun Zhang
Research01 Nov 2021
Nature Chemical Biology

Volume: 17, P: 1305-1313
Mn²⁺ induced significant improvement and robust stability of radioluminescence in Cs₃Cu₂I₅ for high-performance nuclear battery

Fluorescent-type nuclear batteries are a promising semi-permanent power source, but performance is hindered by scintillator development. Here the authors report a scintillator with high light yield and stability, which leads to improved performance.

Xiaoming Li
Jiaxin Chen
Haibo Zeng
ResearchOpen Access23 Jun 2021
Nature Communications

Volume: 12, P: 1-9
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

Chunsik Lee
Rongyuan Chen
Xuri Li
ResearchOpen Access18 Aug 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-14
PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407

Xin Tan
Shuai Chen
Wenlin Huang
ResearchOpen Access16 Mar 2017
Cell Death & Disease

Volume: 8, P: e2686
RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-κB-IL-8 axis

Rong Geng
Xin Tan
Shuai Chen
ResearchOpen Access10 Aug 2017
Cell Death & Disease

Volume: 8, P: e2994

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2D quasi-layered material with domino structure

Generic protein–ligand interaction scoring by integrating physical prior knowledge and data augmentation modelling

Biosynthesis of triacsin featuring an N-hydroxytriazene pharmacophore

Mn2+ induced significant improvement and robust stability of radioluminescence in Cs3Cu2I5 for high-performance nuclear battery

VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407

RNF183 promotes proliferation and metastasis of colorectal cancer cells via activation of NF-κB-IL-8 axis

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Mn²⁺ induced significant improvement and robust stability of radioluminescence in Cs₃Cu₂I₅ for high-performance nuclear battery