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The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Wearable and implantable electronics—including an active-matrix array of thin-film transistors—can be created using transfer-printing of self-healing and stretchable films based around self-healing polymer composites with insulating, semiconducting or conducting properties.

Seo et al. present an approach to regulate the formation and optoelectronic quality of the SnO₂ electrodes, improving electroluminescence and efficiency in perovskite solar cells.

Lack of standardization between biofoundries limits their operational efficiency. In this perspective the authors advocate for a common framework to improve interoperability and reproducibility.

Lung tissue-resident memory T cells play critical roles in the response to and protection to subsequent re-exposure and infection with influenza viruses. Here the authors explore vaccine induced lung resident memory T cells and their role in protection to heterosubtypic influenza infection in mice and ferrets.

Compact laser-wakefield-driven X-ray sources show promise but suffer from poor conversion efficiency. New research demonstrates high-yield, hard X-rays generated by using carbon nanotube targets, instead of gases.

Laser-driven proton acceleration has faced a persistent 100-MeV energy barrier hindering its broader applications. Here, authors achieved the acceleration of protons beyond 110 MeV with an ultrahigh-contrast multi-petawatt laser pulse and a conduction-restricted nm-thick polymer foil.

Phosphatases are key components in cellular signalling networks. Here, the authors present a systematic functional analysis of phosphatases of the fungal pathogen Cryptococcus neoformans, revealing roles in virulence, stress responses, O-mannosylation, retromer function and other processes.

Regulatory T cells, and to certain extent other T cell subsets, limit the immune response to avoid harmful inflammation and tissue damage. Here authors identify a surface molecule, Lrig1, that is directly responsible for the suppressive function in regulatory T cells and in Il-17-producing helper T cells.

Zinc-based batteries face inhomogeneous zinc deposition/stripping. Here the authors show zincophilic copper oxide nanoparticles enhance zinc electrodeposition by reducing nucleation overpotential through strong Zn-CuO interactions, preventing dendritic growth and improving the performance and cyclability of zinc-based flow batteries.

Chromosome-scale and haplotype-resolved assembly of Pinus densiflora sheds light on Pinus-specific genome enlargement. Comparison between haplotypes and resequencing of 30 wild accessions show allelic imbalance with roles in flowering regulation and stress resistance.

Choo, Lee et al. computationally and experimentally investigate how the thermal resistance and surface cooling of thermoelectric legs with different geometries impact the power output of Cu₂Se thermoelectric materials.

Grain boundaries in polycrystalline materials may offer the opportunity to explore physical phenomena that do not normally occur within the crystal grains. Here, the authors show that twin boundaries in Bi₂Te₃works as an electron supply for the whole bulk material.

The mechanism behind the severely cold winters experienced by the mid-latitudes of the Northern Hemisphere in recent years is not fully understood. Here, the authors combine observational analyses and model experiments to reveal a dynamic connection between Arctic sea-ice cover and the polar stratosphere.

Generation of ultrafast X-rays using lab-based laser sources is promising for numerous spectroscopic and imaging techniques. By generating a long underdense plasma in a solid, Kim et al.show relativistic frequency upshift of a laser pulse to 4.9 nm, caused by reflection from electron nanosheets.

Low-molecular-weight heparin (LMWH) has enhanced anticoagulant efficacy, long duration of action, and extended half-life, but achieving long-term efficacy is challenging. Here, the authors design and evaluate a nanoengineered LMWH and octadecylamine conjugate (LMHO) that can act for a long time while maintaining close to 97% of LMWH activity via end specific conjugation of the reducing end of LMWH.

Here, the authors show that higher levels of the gut bacterial clade TANB77 associate with better response to cancer immunotherapy, and further demonstrate in mice that a conserved pilin from TANB77 plays a role in enhancing immunotherapy efficacy, suggesting a potential therapeutic avenue.

Quantum-mechanical band-to-band tunnelling can be used to create an energy-efficient ternary logic technology that can be fabricated on the wafer scale using complementary metal–oxide–semiconductor (CMOS) processes.

Block copolymers that form nanodomains and are used in nanolithography usually do not form nanopatterns with multiple shapes. Here the authors report a block copolymer that allows for UV- induced cleavage of one arm and demonstrate the transformation of the cylindrical to the lamellar nanodomain.

Using a genome-wide association studies approach and patient brain tissue, Kim, Hwang et al. link Ebp1 to Alzheimer’s disease (AD). They show that a conditional Ebp1 knockout mouse model mimics phenotypes of sporadic AD and find that EBP1 reduces amyloid β production by inhibiting γ-secretase.

Here, the authors provide mechanistic insight into light-induced dimerization of a Light-Oxygen-Voltage (LOV) ___domain using time-resolved X-ray liquidography, furthering our understanding LOV ___domain photoactivation and protein-protein interaction-driven oligomerization.

Anomalous Arctic warming has been linked to colder North American winters. Analyses of weather and productivity observations reveal that Arctic–North American teleconnections reduce gross primary productivity in the US.

Stretchable radio-frequency electronics based on a dielectro-elastic elastomer is demonstrated to be capable of completely maintaining operating frequencies unaffected by strain and shows superior electrical, mechanical and thermal properties compared with conventional stretchable substrate materials.

Therapies and vaccines for COVID-19, caused by the SARS-CoV-2 viral pandemic, are urgently needed. Here the authors establish and screen an antibody library from a convalescent COVID-19 patient to isolate a neutralizing antibody with the ability to reduce viral titer and alleviate symptoms in ferret, hamster, and rhesus monkey infection models.

Seminal fluid is high in sugars, primarily to aid in sperm motility though it is unclear whether they serve other roles. Here they use Drosophila to identify a bioactive sugar, venerose, that stimulates female brain neurons to boost germline stem cell proliferation and sperm storage.

Invariant natural killer T (iNKT) cells have recently been reported to play a key role in adipose tissue homeostasis. Here, the authors show that adipose tissue iNKT cells mediate immune responses that control adipocyte turnover in mice.

Here, the authors utilise NMR and MD simulations to reveal how transcription factor Meis1 distinguishes target DNA sequences through non-specific binding.

The fungus Fusarium graminearum produces a toxin, deoxynivalenol (DON), that can be found in cereal grains and processed food or feed. Here, Huang et al. study the regulation of DON biosynthesis and show that transcription factors TRI6 and TRI10 regulate each other’s expression and that of a long non-coding RNA which, in turn, downregulates a DON biosynthesis gene.