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This study presents a physics informed neural network which monitors and directs the melt pool in a robotic welding and additive manufacturing scenario. Combining X-ray and real time melt pool data, forward prediction of properties is provided.

Polymer crystals usually grow at conditions far away from thermodynamic equilibrium, but understanding of metastable states within polymer crystals remains limited. Here the authors use selective dissolution to investigate the time- and space-dependent dissolution velocities of polymer crystals and investigate the relation between growth kinetics and the resulting metastability within lamellar polymer single crystals.

This study of Chinese endometrioid endometrial carcinomas describes the proteogenomic differences between early-onset and late-onset tumors, finding that SIGLEC10 mutation may contribute to tumorigenesis and progestin resistance in early cases.

Multiple domestication-related traits in cultivated soybeans are pleiotropic effects of a locus composed of two tandemly duplicated long noncoding RNAs that act via sRNA repression of MYB transcription factors.

Neutral sphingomyelinases play pivotal roles in ceramide-related signaling transduction. Here, the authors solve the structure of human neutral sphingomyelinase SMPD2 and propose a catalytic mechanism, potentially enhancing understanding of ceramide in disease and cancer treatment.

Macrophage is located in different tissue to serve diverse functions. Here the authors use mass spectrometry and bulk RNA-sequencing to profile 11 mouse macrophage populations from 8 tissues, and combine their de novo data with public datasets to report an integrated proteomic and transcriptomic landscape of mouse macrophage as a valuable resource.

Ferroptosis is lipid peroxidation-dependent cell death that has potential to be harnessed as a cancer therapeutic. Here, the authors show that the translation initiation factor eIF4E can repress ALDH1B1 independent of translation, increasing lipid peroxidation levels to promote ferroptosis.

The peptide hormone relaxin has potential in the treatment of acute heart failure, but it must be intravenously injected and has a short half-life after administration. Now, small-molecule alternatives to relaxin are reported with similar efficacies to the natural hormone in functional assays.

Squamous cell carcinomas are an aggressive cancer type which can occur in multiple organ systems. Here, the authors analyse the proteome of SCC cancers from 17 organs and show commonly dysregulated proteins independent of ___location.

2D biochemical sensors hold potential for monitoring toxic contaminants in water, but they are usually affected by device-to-device variations. Here, the authors propose a scalable fabrication process and quality control procedure to realize graphene field-effect transistor arrays able to simultaneously detect trace amounts of heavy metal ions and bacteria in flowing water.

The time-varying metasurfaces show promise for exploring exotic physics and photonic applications. The authors introduce a time-varying metasurface with superconductor-metal hybrid meta-molecules, demonstrating phase-controllable frequency conversion with high efficiency.

Towards intelligent treatment for glaucoma, here authors demonstrate integrated wireless theranostic contact lenses for in situ electrical sensing of intraocular pressure and on demand anti-glaucoma drug delivery.

Bioinks used in current in-situ bioprinting have limitations when applied to complex operational environments. Here, the authors report on the creation of a microgel reinforced GelMA bioink which can be simply prepared and used in different biomedical settings. The application is demonstrated in a cranial defect model.

Transcription factor regulatory networks underlie major features of cellular identity and complex function such as pluripotency, development and differentiation. Li and colleagues develop a graph neural network to predict transcription factor regulatory networks based on single-cell ATAC-seq data.

Nasopharyngeal carcinoma (NPC) is a malignant cancer type with high morbidity in Asia, and its current molecular classification is insufficient to predict therapy outcomes. Here the authors explore NPC subtype-specific response to therapy with a pharmacogenomics strategy integrating genomics and drug response of patient-derived organoids.

Multi-omics profiling of matched normal colon, primary tumor, and liver metastasis from colorectal carcinoma patients based on Hi-C, ATAC-seq and RNA-seq technologies sheds light on the changes and regulatory mechanisms of 3D genomics during the tumorigenesis and metastasis of colorectal carcinoma.

Due to reduced gibberellin sensitivity, modern rice cultivars are shorter than traditional varieties but produce more tillers and have higher yields. Here Liao et al. show that gibberellin contributes to decreased tiller number by degrading the MOC1 protein that suppresses bud outgrowth.

Phosphorene is one of a growing number of 2D materials with high potential for device applications. Here, the authors report a sensor composed of phosphorene nanosheets, showing a high sensitivity to NO₂in dry air and also demonstrate that the sensitivity depends on the nanosheet thickness.

Understanding the flow of heat in materials just one or a few atoms thick is vital for harnessing them in compact electronic devices. Here, the authors present the temperature-dependent thermal conductivity of black phosphorus ribbons and demonstrate an intrinsic orientation dependence.

The efficiency of organic solar cells depends on the timescale of charge separation, with fast separation achieved through large driving forces. Liu et al. show that non-fullerene organic blends exhibit fast charge separation and efficiency of 9.5% even in the presence of only small driving forces.

Spin currents are generated from an antiferromagnet/heavy-metal heterostructure using optical excitation on picosecond timescales. This will have applications in antiferromagnetic spintronics.

As a circadian organ, liver functions are regulated by circadian clock. Here, the authors present a comprehensive proteomics landscape of the mouse liver, including transcription factor binding profiles, phosphorylation and ubiquitylation patterns, nuclear and whole proteome, and the transcriptome.

Metabolic reprogramming of smooth muscle cells (SMCs) plays an important role in the pathogenesis of pulmonary arterial hypertension (PAH). Here, Dai et al. show that the glycolytic enzyme alpha-enolase contributes to this reprogramming, and that its inhibition limits SMC proliferation and disease progression in animal models of PAH.

Osteoarthritis (OA) is associated with cartilage degeneration, and no effective therapy exists. Here, the authors show that the HPIP protein modulates OA progression by regulating Wnt signaling, and that its knockdown in joints via AAV-mediated gene silencing attentuates pathology.

This work reports a quantitative investigation of the interaction parameter and miscibility of donor and acceptor organic molecules and their relationship with the fill factor and photovoltaic performance of bulk-heterojunction organic solar cells.

The One Thousand Plant Transcriptomes Initiative provides a robust phylogenomic framework for examining green plant evolution that comprises the transcriptomes and genomes of diverse species of green plants.

A thermally active terahertz Janus metasurface with direction dependence and reconfigurability was reported. Bidirectional and dynamic control of electromagnetic functions, such as asymmetric meta-lens and directional holographic imager, were achieved.