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Tooth enamel-inspired ceramic coating (ZrO₂ nanorod and amorphous intergranular phase) enhances Zr foil for lightweight, enhanced mechanical properties and corrosion resistance, and this strategy can be universally applied to Ti, Zn, Cu.

Microwave-assisted tumour-derived microparticles enhance antitumour activity, safety and drug delivery, outperforming traditional ultraviolet-derived methods.

Here, the authors develop a high-throughput assay to measure the jumping potential of thousands of transposons in parallel.

Perovskite solar cells often rely on ordered molecular contacts for favourable charge-carrier transport, and any organizational disruption reduces device efficiency. Now a contact featuring an orthogonal π-skeleton has been shown to afford a high resilience to external stimuli plus long-term durability in accelerated-ageing tests.

Self-assembled monolayers targeting wide-bandgap perovskite solar cells are essential to reduce the open-circuit voltage loss. Here, the authors report the stepwise tuning of interfacial energy level through inductive effect, achieving perovskite/TOPCon tandem solar cells with efficiency over 31%.

A computational framework to integrate microbial GWAS and single-cell RNA-sequencing profiles of 24 human organs reveals interactions between the host cells and microbes.

Scaling up perovskite film deposition necessitates controlling the film formation dynamics. Here, Deng et al. use amphoteric choline surfactants to blade-coat well-passivated films, reaching module efficiencies of ~15% for aperture areas up to 57 cm².

The piezoelectricity of ferroelectric oxide films is limited by substrate clamping, and their rigidity hinders their applications in flexible electronics. Herein, authors report freestanding PbZr0.52Ti0.48O3 nanoscale membranes with both high piezoelectricity and high flexibility.

Low-loss superconducting aluminium cables and on-chip impedance transformers can be used to link qubit modules and create superconducting quantum computing networks with high-fidelity intermodule state transfer.

Mechanical compatibility is highly desirable for enamel restorative materials. Here, the authors engineer a hierarchical enamel analog with comparable mechanical properties as outer enamel, showing great potential for enamel restoration.

Sphingosine-1-phosphate receptor 1 (S1PR1) is a drug target for inflammatory bowel disease (IBD), impacting immune cell movement, but current treatments carry immunosuppression risks. Here, the authors show that a Gi-biased S1PR1 agonist, SAR247799, protects the endothelial barrier in IBD models without affecting immune cell egress, offering a potential new treatment strategy.

Existing image-activated cell sorting tools suffer from the challenges of 3D information loss and processing latency in real-time sorting operations. Here, the authors propose a neuromorphic-enabled video-activated cell sorter (NEVACS) framework, which achieves high-dimensional spatiotemporal characterization content and high-throughput sorting of particles.

The combination of targeted therapeutic agents for metastatic colorectal cancer (mCRC) salvage treatment has potential in clinics. Here this group conducts a single-arm, open-label, phase II trial assessing the combination therapy of regorafenib (tyrosine kinase inhibitor) and sintilimab (PD-1 targeting) as a safe and effective salvage-line treatment for mCRC patients who have progressed upon second-line treatment.

A multi-ancestry genome-wide gene–smoking interaction study identifies 13 new loci associated with serum lipids.

Sequencing of haploid sugarcane, Saccharum spontaneum, allows assembly of a prototypical version of the sugarcane chromosome set. This new reference genome will serve as a resource to accelerate sugarcane improvement.

We describe the structure and activity of Cas14 nuclease, a component of the type VII CRISPR–Cas interference complex with Cas5 and Cas7, in different functional states.

Difficulties in propagating HRV-C have hindered our understanding of this common respiratory pathogen. Here, authors developed an organoid-based system to reproducibly propagate HRV-C and characterized HRV-C infection in physiologically active respiratory organoids.

Genome assemblies for the SunUp transgenic papaya and its progenitor Sunset identify three transgene-insertions in SunUp. Resequencing of 86 papaya genomes highlights the impacts of breeding and geographic origin.

Polyester waste is increasingly accumulating in the environment, and alcoholysis recycling offers a sustainable management solution. This study demonstrates the use of an oxygen vacancy-rich catalyst to transform waste blended polyester/textiles into high-value monomers.

The authors design double shelled hollow superstructures from self-assembled CdSe/CdS nanorods in covalent organic frameworks for CO2 photo-reduction at a gas/solid interface.

Methylammonium-free perovskite solar cells have achieved promising efficiency and thermal stability yet iodide migration limits their operational stability. Deng and colleagues show that an excess of formamidinium or caesium iodide precursor suppresses iodide vacancies preventing ion migration and eventually the generation of hole traps during device operation.

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

It is useful to be able to equip marine animals with sensors, but it can be challenging to attach these to soft marine organisms. Here, the authors use an adhesive hydrogel to achieve rapid attachment of sensors to marine life including jellyfish, squid and lobster.

TAAR1 has a rigid consensus binding motif that binds to endogenous trace amine stimuli as well as two extended binding pockets that accommodate diverse chemotypes.

As cancer is increasingly considered a metabolic disorder, it is postulated that serum metabolite profiling can be a viable approach for detecting the presence of cancer. Here, the authors report a machine learning model using mass spectrometry-based liquid biopsy data for pan-cancer screening and classification.

A study shows that implants with an adhesive implant–tissue interface mitigate the formation of a fibrous capsule when attached to various organs in mice, rats and pigs.

To run algorithms on a computer they are broken down into logical operations that are implemented in hardware. A quantum logical AND gate has now been demonstrated, which could substantially improve the efficiency of near-term quantum computers.

Bioresorbable silicon-based optoelectronic thin films can selectively excite or inhibit neural activities, as shown in mice with exposed sciatic nerves and somatosensory cortices.

High-entropy hybrid perovskites exhibit improved materials properties compared with their individual components. When employed in solar cells, champion devices achieve a certified power conversion efficiency of 25.5% and an extrapolated T₉₀ lifetime of over 5,000 h under continuous light soaking.

Carbon materials are widely used in electrochemical technologies. However, their intrinsic conductivity deteriorates over time. Here the authors build a highway-mediated nanoarchitecture of ordered pseudographitic nanodomains to promote charge transfer for electrochemical ion capture.

A graphene nanocomposite hydrogel showing anisotropic swelling is used to realize an electrically conducting and removable bioadhesive that improves the mechanical and electrical integration of bioelectronics devices with wet dynamic tissues.

In a randomized, double-blind phase 3 trial, the anti-α₄β₇ integrin monoclonal antibody vedolizumab plus standard prophylaxis was superior to placebo plus prophylaxis for prevention of lower gastrointestinal acute graft-versus-host disease in patients following allogeneic hematopoietic stem cell transplantation.

Gas sorption studies in porous materials typically reflect their overall gas uptake. Now, using a ‘gas adsorption crystallography’ method, the gas adsorption isotherms of two metal–organic frameworks (MOFs) have been quantitatively decomposed into sub-isotherms that reflect the pore-filling behaviour of various guests in the different types of pores present in the MOFs.

Wu et al. show that LILRB3 modulates AML cell survival and antileukemic T-cell responses through regulation of TRAF2–cFLIP–NF-κB signaling and demonstrate the therapeutic efficacy of LILRB3-blocking antibodies in humanized PDX models in vivo.

Defects in interleukin-22 production and group 3 innate lymphoid cells are correlated with aggravated gut inflammation. Wu et al. find that proline uptake via the proline transporter Slc6a7 is involved in activation of lymphoid tissue inducer cells and interleukin-22 production in the gut, and that dietary supplementation with proline alleviates colitis in a mouse model.

Gene regulatory grammar remains difficult to decipher, hindering our ability to link genotype to phenotype. Here they use massively parallel reporter assays to test over 200,000 synthetic sequences, finding that transcription factor binding site order and orientation have a major effect on gene regulatory activity.

Wu et al. show that, upon activation by insulin-like growth factor 1 receptor and AKT, creatine kinase B exhibits a moonlighting function as protein kinase to phosphorylate glutathione peroxidase 4 to prevent its degradation, thereby suppressing ferroptosis and enhancing tumour growth in mice.

Tin-based perovskites possess the suitable narrow-bandgap for tandem solar cells but their short carrier diffusion lengths limit device efficiency. Here Yang et al. add cadmium ions to increase diffusion length to above 2 µm by reducing the background free hole concentration and electron trap density.

High-quality genome sequence of cultivated peanut comprising 2.54 Gb with 20 pseudomolecules and 83,709 protein-coding gene models provides insights into genome evolution and the genetic mechanisms underlying seed size and leaf resistance in peanut.

A detailed analysis of IncX plasmids identifies PrfaH as crucial for conjugation and H-NS as a regulator of the balance between conjugation and host fitness, highlighting PrfaH as a potential target for combating antimicrobial resistance.