Metabolic reprogramming is crucial for cancer progression. Here, the authors show that the high mobility group A1 (HMGA1) promotes colorectal cancer (CRC) in a AOM/DSS-induced mouse model, by enhancing lipid synthesis via upregulation of fatty acid synthase (FASN), and inhibiting FASN reduces tumor growth, suggesting potential therapeutic avenues.
- Yuan Zhao
- Meng-Jie Liu
- Zhi-Xiang Xu
