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Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells

DIS3 deficiency alters CTCF and cohesin binding at the Igh locus in B cells. These cells show decreased class-switch recombination but increased chromosomal translocations.

Brice Laffleur
Junghyun Lim
Uttiya Basu
Research01 Feb 2021
Nature Genetics

Volume: 53, P: 230-242
Location is a major barrier for transferring US fossil fuel employment to green jobs

This study tests the case for the absorption of current fossil fuel workers in emerging green jobs from the perspective of their skills and ___location. It finds ___location to be a barrier in a Just Transition for these workers.

Junghyun Lim
Michaël Aklin
Morgan R. Frank
ResearchOpen Access26 Sept 2023
Nature Communications

Volume: 14, P: 1-9
Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer

Patients with MMR-proficient, microsatellite stable (MSS) colorectal cancer (CRC) are highly resistant to immune-checkpoint inhibitors. Here the authors report that tumor intrinsic expression of the autophagy gene ATG16L1 is associated with resistance to anti-tumor immunity in preclinical CRC models and that elevated ATG16L1 expression predicts poor immunotherapy response in Kras-mutant CRC patients.

Lucia Taraborrelli
Yasin Şenbabaoğlu
Aditya Murthy
ResearchOpen Access23 Sept 2023
Nature Communications

Volume: 14, P: 1-17
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression

Whole-genome analysis of paired follicular lymphoma and double-hit lymphoma shows that lymphoma progression is accompanied by enhanced somatic mutations targeting super-enhancer-embedded promoters.

Rebecca J. Leeman-Neill
Dong Song
Uttiya Basu
ResearchOpen Access04 Dec 2023
Nature Genetics

Volume: 55, P: 2160-2174
Machine learning based prediction for oncologic outcomes of renal cell carcinoma after surgery using Korean Renal Cell Carcinoma (KORCC) database

Jung Kwon Kim
Sangchul Lee
Hyeju Oh
ResearchOpen Access08 Apr 2023
Scientific Reports

Volume: 13, P: 1-8
In-situ local phase-transitioned MoSe₂ in La_0.5Sr_0.5CoO_3-δ heterostructure and stable overall water electrolysis over 1000 hours

While catalysts are necessary for H₂ and O₂ production from water, developing materials capable of evolving both under the same conditions has proven challenging. Here, authors prepare perovskite-oxide and molybdenum sulfide heterostructures as bifunctional water-splitting electrocatalysts.

Nam Khen Oh
Changmin Kim
Hyesung Park
ResearchOpen Access12 Apr 2019
Nature Communications

Volume: 10, P: 1-12
Selective autophagy of the adaptor TRIF regulates innate inflammatory signaling

Polymorphisms in the autophagy protein Atg16l are associated with human inflammatory bowel disease. Murthy and colleagues demonstrate that atg16l is crucial to autophagocytic degradation of the innate adapter TRIF and thereby restrains pathological over-production of type I interferons.

Mohammad Samie
Junghyun Lim
Aditya Murthy
Research22 Jan 2018
Nature Immunology

Volume: 19, P: 246-254
Fast and efficient method for parallel construction of targeted exome and methylome single-stranded DNA sequencing libraries

Eunhye Kim
Sinae An
Ae Kyung Park
ResearchOpen Access28 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Dynamic O-GlcNAcylation governs long-range chromatin interactions in V(D)J recombination during early B-cell development

Bong Chan Jeon
Yu-Ji Kim
Sung-Kyun Park
Research03 Dec 2024
Cellular & Molecular Immunology

Volume: 22, P: 68-82
Noncoding RNA transcription targets AID to divergently transcribed loci in B cells

The 11-subunit RNA exosome is thought to regulate the mammalian noncoding transcriptome; here, a mouse model is generated in which the essential Exosc3 subunit of the RNA exosome in B cells is conditionally deleted, revealing a link between sites of genomic RNA exosome function and AID-mediated chromosomal translocations.

Evangelos Pefanis
Jiguang Wang
Uttiya Basu
Research06 Aug 2014
Nature

Volume: 514, P: 389-393
Early pulmonary fibrosis-like changes between delta and pre-delta periods in patients with severe COVID-19 pneumonia on mechanical ventilation

Jung-Wan Yoo
Won-Young Kim
Jin Woo Song
ResearchOpen Access30 Oct 2024
Scientific Reports

Volume: 14, P: 1-9
ECMO is associated with decreased hospital mortality in COVID-19 ARDS

Won-Young Kim
Sun-Young Jung
Jin Woo Song
ResearchOpen Access27 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
Controlling inflammation by selective autophagy

Junghyun Lim
Aditya Murthy
Comments & Opinion14 Mar 2018
Cell Death & Differentiation

Volume: 25, P: 825-827

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