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Current-driven dynamic atomic rearrangements in layered In₂Se₃ are visualized. The authors identify an intralayer ‘unzipping’ and interlayer ‘zipping’ phase-transition pathway in which bond formation across the van der Waals gaps drives bond cleavage within covalent layers.

The DCAF15 E3 ubiquitin ligase is targeted by aryl-sulfonamide molecular glues leading to neo-substrate proteasomal degradation. Here, the authors reveal DCAF15 as a cell autonomous acute myeloid leukemia dependency sustaining proliferation through control of cohesin complex recycling dynamics.

Strong magnetic interfacial coupling in van der Waals heterostructures provides a new platform for discovering novel physics and effects. Here, the authors report the formation of skyrmion lattice in the WTe₂/Fe₃GeTe₂ van der Waals heterostructure and a Dzyaloshinskii–Moriya interaction with a large energy density of 1.0 mJm⁻².

The altermagnetic order in CrSb films can be manipulated via crystal symmetry; the reconstructed altermagnetic order generates a room-temperature spontaneous anomalous Hall effect and designable switching modes as field-assisted and field-free modes.

The structure of vaterite has been debated for a century. Combining systematic TEM characterisations, crystallographic analysis, and machine learning aided molecular dynamics simulations, the authors unlock the structural mystery in vaterite.

Depression has been recently linked to the visual cortex. Here, the authors identify a glutamatergic primary visual corticallateral posterior thalamic nucleus circuit and its key regulator, Gγ4, as modulators of depressive-like behaviors in male mice.

Reconstructive phase transitions in materials are usually slow due to large activation energy barriers. Here, the authors show a kinetically favorable layer-by-layer mechanism in Ti₃O₅ transformations using machine-learning molecular dynamics simulations.

There are now several van der Waals magnets that have been shown to host skyrmions, however, these are typically hampered by a low Curie temperature, restricting the temperature at which the skyrmions can exist. Here, Zhang, Jiang, Jiang and coauthors find a skyrmion lattice in the van der Waals magnet Fe3 − xGaTe2 above room temperature and demonstrate the critical role of symmetry breaking in crystal lattice in the origin of these skyrmions.

How age-accumulated mtDNA mutations in the small intestine modulate intestinal homeostasis is unclear. Here, the authors show that increased mtDNA mutation burden triggers an ATF5 dependent UPRmt by NAD⁺ depletion, and thus regulates intestinal aging through impaired Wnt/β-catenin signaling.

Quantum degrees of freedom, such as spin or valleys, lie at the basis of many intriguing phenomena. In this theory work, the authors present a new type of spin-valley locking enabled by a crystalline symmetry, which allows for the generation of valley polarizations and net magnetization via strain, and non-collinear spin currents via charge currents.

CTCF plays key roles in gene regulation, chromatin insulation and organizing the higher-order chromatin architecture of mammalian genomes. Here the authors investigate the function an alternatively spliced shorter CTCF isoform, finding that this isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis.

Sodium-based dual-ion batteries are promising electrochemical energy storage devices. Here, the authors report a source-template synthetic strategy to prepare carbon-coated MoS_1.5Te_0.5 nanocables and their use as anode active materials in Na-based dual ion cells.

Fluorescence imaging and fluorescence recovery after photobleaching assays reveal that the mitochondrial nucleoid forms a suborganelle via liquid–liquid phase separation interactions between mitochondrial DNA and the mitochondrial transcriptional machinery.

Antibodies against SARS-CoV-2 S protein can provide a treatment strategy for COVID-19. Here, Guo et al. provide the crystal structure of a SARS-CoV2 neutralizing antibody isolated from a convalescent patient and highlight the therapeutic efficacy in a rhesus monkey model of an engineered version with optimized pharmacokinetic and safety profile.

Electroreduction of CO₂ on single atom catalysts is often hindered by electron delocalization of the metal sites. To improve CO₂ activation, here the authors functionalize the carbon support with cyano moieties, thereby attenuating metal-substrate conjugation and improving CO₂ to CO conversion.

General methods to introduce functional components into metal-organic frameworks are challenging to develop. Here, the authors report a method for encapsulating a range of functional components, such as proteins and nanoparticles, into the structures with properties dependent on both the framework and the guest.

Iron phthalocyanine with a 2D structure and symmetric electron distribution around Fe-N₄ active sites is not optimal for O₂ adsorption and activation. Here, the authors report an axial Fe–O coordination induced electronic localization strategy to enhance oxygen reduction reaction performance.

Two-dimensional transition metal dichalcogenides with peculiar spin–orbit coupling may lead to exotic phenomena. Here, the authors report a large in-plane upper critical field with a two-fold symmetry, suggesting a novel asymmetric spin–orbit coupling in few-layer 1T_d-MoTe₂.

A framework applicable in different imaging modalities can facilitate the medical imaging reconstruction efficiency but hindered by inefficient information communication across the data acquisition and imaging domains. Here, Jiadong Zhang and coworkers report a dual-___domain generative framework to explore the underlying patterns across domains and apply their method to routine imaging modalities (computed tomography, positron emission tomography, magnetic resonance imaging) under one framework.

BRD8 is identified as a specific epigenetic vulnerability for glioblastomas that harbour wild-type p53.

The existence of linear-chain configurations in light nuclei has been predicted for decades, but the finding of the exact ___location on the nuclear chart where this exotic structure emerges has proven to be challenging experimentally. Here, the authors performed an inelastic excitation and cluster-decay experiment followed by unambiguous spin-parity analyses and provide evidence for the emergence of the nuclear chain structure starting from ¹⁴C.

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Transition metal dichalcogenides exhibit rich polymorphism, making them promising candidates for superconductors, topological insulators, and electrochemical catalysts. Here, the authors study the metallization of non-hydrostatically compressed ZrS₂ up to 45.8 GPa and find that a new high-pressure phase forms under deviatoric stress.