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Showing 1–5 of 5 results
Advanced filters: Author: Karthikeyani Chellappa Clear advanced filters

  • Lundgren et al. show that in response to transient cold exposure, a distinct subpopulation of brown adipocytes carries out a lipogenic response involving production of acylcarnitines, which enables an improved thermogenic response to secondary cold exposure.

    • Patrick Lundgren
    • Prateek V. Sharma
    • Christoph A. Thaiss
    Research
    Nature Metabolism
    Volume: 5, P: 1691-1705

  • Chini et al. demonstrate that CD38+ expression in immune cells increases during aging, owing to the senescence-associated secretory phenotype of senescent cells, and the ecto-enzymatic activity of CD38+ affects intracellular NAD+ levels in vivo by hydrolyzing the NAD+ intermediate nicotinamide mononucleotide extracellularly.

    • Claudia C. S. Chini
    • Thais R. Peclat
    • Eduardo N. Chini
    Research
    Nature Metabolism
    Volume: 2, P: 1284-1304

  • Levine and colleagues demonstrate that the effects of caloric restriction on hepatic gene expression, circulating acylcarnitines and body temperature are largely mediated by an increase in the daytime peak of NADH concentration in the liver.

    • Karthikeyani Chellappa
    • Joseph A. Baur
    News & Views
    Nature Metabolism
    Volume: 3, P: 1589-1590

  • It is demonstrated that the brain circuitry involved in regulating the motivation for physical activity is not strictly central nervous system autonomous but is shaped by peripheral influences that originate in the intestinal microbial community.

    • Lenka Dohnalová
    • Patrick Lundgren
    • Christoph A. Thaiss
    Research
    Nature
    Volume: 612, P: 739-747