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Combining chemo- and biocatalytic sites within an integrated catalyst to perform complex, multi-step reactions is highly desirable but challenging. Here, the authors present an ionic organic cage platform for such a chemoenzymatic catalyst, achieved by electrostatic complexation of cationic molecular cage-encapsulated Pd clusters (Pd@C-Cage⁺) and anionic Candida antarctica lipase B.

Two genetically linked TdNLR genes from wild emmer wheat are both required for YrTD121-mediated stripe rust resistance. The TdNLR1 and TdNLR2 pair lacks an integrated ___domain, representing an uncommon architecture for paired NLRs in plants.

Patients with gastric cancer often present with poor performance status, limiting both quality of life but also treatment options as they are often excluded from clinical trials. Here, the authors report a phase II trial investigating anlotinib (multi-TKI) plus toripalimab (anti-PD-L1 monoclonal antibody) in treatment-naïve advanced gastric cancer patients with performance status 2.

A dynamic Cu–Pt dual-atom catalyst supported on 1Tʹ-MoS₂ can be electrically switched between single- and dual-atom configurations, enabling on-demand control for alkyne semi-hydrogenation.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Neovascular eye diseases cause blindness, but underlying drivers are unclear. Here, the authors show that PRL3 promotes pathological angiogenesis, and that targeting PRL3 with an antibody therapy could offer a new treatment for ocular neovascularization.

Aerodynamic analysis of SARS-CoV-2 RNA in two hospitals in Wuhan indicates that SARS-CoV-2 may have the potential to be transmitted through aerosols, although the infectivity of the virus RNA was not established in this study.

Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K.

The authors report the transformation of an amorphous covalent organic framework to a crystalline state. This results in achieving optimum surface properties and enhances the photocatalytic production of hydrogen gas.

The authors identify feimin as a feeding-induced myokine that regulates glucose homeostasis via the MERTK–AKT signalling axis in mice and humans.

Quantum speed limits are fundamental constraints on the speed of quantum state evolution. Here, the authors observe the known maximal quantum speed limits for few and many-body states on a superconducting quantum processor and identify the minimal quantum speed limits, which are less common than maximal ones.

The three-dimensional conformation of macrocycles determine their chemical and recognition properties and the factors that influence the interconversion between macrocyclic forms are poorly understood. Here the authors describe a macrocycle existing as two stable atropisomers and the mechanism behind the thermally-induced transition between them.

Adaptive charge capture increases the initiation voltage of electrical trees in anthrone/cross-linked polyethylene by 123%. Organic semiconductors capture charges and construct reverse electric fields, reducing the electric field strength of the insulator and enhancing its reliability.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

The thinness and elastic properties of graphene make it an ideal candidate for nanoelectromechanical systems. Here, the authors demonstrate the positive piezoconductive effect in suspended bi- and multi-layer graphene, showing the most pronounced response for three layer samples.

Several molecular mechanisms, including TIRR-53BP1 repair axis, regulate DNA repair pathway choice and PARP inhibitor sensitivity. Here, the authors show that ubiquitination of TIRR by DTX3L is a critical process that regulates NHEJ pathway activity and PARP inhibitor sensitivity by facilitating XPO1-mediated TIRR nuclear export and degradation upon DNA damage.

The use of quantum simulators for studying non-equilibrium quantum transport has been limited. Here the authors demonstrate the steady quantum transport between many-body qubit baths on a superconducting quantum processor, revealing insights into pure-state statistical mechanics for nonequilibrium quantum systems.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

The role of the tumor microenvironment in immunotherapy response in intrahepatic cholangiocarcinoma remains unclear. Here, single cell RNA and TCR sequencing of samples before and after immunotherapy highlights the role of CD8 T-cell status conversion and exhaustion induced by Macro CD5L+ in treatment response.

Recently, there have been proposals to extend the concept of time crystals to topological order. Here the authors observe a prethermal topologically ordered time crystal on a superconducting quantum processor, where discrete time-translation symmetry breaking manifests for nonlocal rather than local observables.

Superconducting qubits have been used to realize a quantum many-body state that is capable of universal topological quantum computation.

The Greenberger-Horne-Zeilinger states are multipartite entangled quantum states with strong non-local entanglement. Here the authors generate large-scale states of this type with up to 60 qubits and show that discrete time crystals can effectively protect such fragile states.

Investigating the inner structure of baryons is important to further our understanding of the strong interaction. Here, the BESIII Collaboration extracts the absolute value of the ratio of the electric to magnetic form factors and its relative phase for e + e − → J/ψ → ΛΣ decays, enhancing the signal thanks to the vacuum polarisation effect at the J/ψ peak.

High-quality genome of the modern soybean cultivar Nongdadou2 and deep resequencing of 547 accessions provide insights into the role of structural variations in soybean improvement.

The hippocampus maps space, but its role in encoding investigatory intentions is unclear. Here the authors show that certain CA1 neurons encode both spatial information and animals’ intention to explore, depending on input from lateral entorhinal cortex.

A study using a reverse genetic screen reveals that the Arabidopsis DREAM complex, including its components TCX5/6, functions as a whole in repressing DNA methylation maintenance genes and, consequently, precluding DNA hypermethylation.

Electrochemical CO2 reduction is a promising method of producing sustainable chemicals and fuels, yet is highly energy intensive. Here, the authors couple CO2 electrolysis with hydrogen oxidation using a Ni(OH)₂/NiOOH auxiliary electrode to enhance energy efficiency.

SELECTIV is an efficient method for tissue-specific AAV-mediated transgene expression in mice mediated by AAV receptor overexpression.

The Chinese Liver Cancer Atlas project depicts a panoramic genomic landscape of hepatocellular carcinoma, covering candidate coding and non-coding drivers, mutational signatures, extrachromosomal circular DNA, subclonal catastrophic events and detailed evolutionary history.

The physiological significance of low fatty acid synthesis in adipocytes remains unclear. Here, the authors show a protective role of this phenomenon by demonstrating that overproduction of fatty acids increases ROS production and results in adipocyte necroptosis and lipodystrophy.

Here, the authors solve sequential structures of binding by the transcription activators NtcA and NtcB, showing that they cooperatively induce looping back of the promoter DNA towards RNA polymerase allowing transcription activation through a DNA looping mechanism.

H₂S donors in living cells are essential for modulating H₂S levels and have been proposed to be relevant for managing hepatic disorders, but conventional platforms to screen for H₂S donors are plagued by interference by endogenous background fluorescence signals. Here, the authors develop a luminogenic probe—based on an Ir(III) complex with a 1,10-phenanthroline-5,6-dione moiety—capable of selective response to mitochondrial H₂S, and set up an anti-interference high-throughput screening system capable of distinguishing target signals from complex background autofluorescence in living cells.

Pathologic α-synuclein spreads from cell-to-cell through binding to the lymphocyteactivation gene 3 (Lag3). Here, the authors demonstrate that the amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 and facilitates the binding, internalization, transmission, and toxicity of pathologic α-synuclein.

African Americans have an elevated risk of developing chronic kidney disease, yet only a fraction of those with high-risk genotypes develop the disease. Here, the authors show that a missense variant in APOL1 has a strong protective effect when co-inherited with the high-risk G2 allele of APOL1, with important implications for clinical practice and translational research.

Male breast cancer may involve different populations of immune cells. Here the authors use single cell transcriptomics to show that infiltration of T cells is lower in male breast cancer relative to female breast cancer, and find that this is accompanied by distinct metabolic changes.

Urea electrosynthesis from nitrate and CO₂ is an attractive strategy to diminish pollutants and reduce emissions, but yields are generally low. Now, this process is performed on a Zn/Cu hybrid catalyst achieving high Faradaic efficiency for urea of 75% via a relay catalysis mechanism.

Genome-wide association studies (GWASs) for cigarette smoking have identified several hundred loci that account for a small proportion of the overall genetic risk. Here, the authors report a large GWAS for smoking trajectories and meta-analysis for smoking status, finding multiple plausible loci.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.