Nature Search

Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
A biocompatible Lossen rearrangement in Escherichia coli

Biocompatible chemistry merges chemo-catalytic reactions with cellular metabolism for sustainable small-molecule synthesis. Now a biocompatible Lossen rearrangement has been demonstrated to control bacterial cell growth and chemistry and applied to the remediation and upcycling of polyethylene terephthalate plastic waste in whole-cell reactions and fermentations to produce valuable industrial chemicals, including the drug paracetamol.

Nick W. Johnson
Marcos Valenzuela-Ortega
Stephen Wallace
ResearchOpen Access23 Jun 2025
Nature Chemistry

P: 1-7
In vitro flow properties of Preserflo Michroshunt with an intraluminal stent

Enrico Lupardi
Antonio Cassiano
Keith Barton
Research11 Jun 2025
Eye

P: 1-6
Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

Jie Shen
Wander Valentim
Gita A. Pathak
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-17
Observation of polarization density waves in SrTiO₃

Despite exhibiting ferroelectric features, SrTiO₃ fails to display long-range polar order at low temperatures due to quantum fluctuations. An ultrafast X-ray diffraction experiment now probes polar dynamics of this material at the nanometre scale.

Gal Orenstein
Viktor Krapivin
Mariano Trigo
Research07 Apr 2025
Nature Physics

Volume: 21, P: 961-965
Regulatory functions of the λ repressor reside in the amino-terminal ___domain

Robert T. Sauer
Carl O. Pabo
Keith C. Backman
Research01 May 1979
Nature

Volume: 279, P: 396-400
NEHPROLOGY FIRST SESSION May 17, 1973, 9:00 A.M. Continental Parlor 7–8

Keith N Drummond
Research01 Apr 1973
Pediatric Research

Volume: 7, P: 53-56
Editorial Expression of Concern: A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

Cory M. Johannessen
Laura A. Johnson
Levi A. Garraway
Amendments and Corrections24 Apr 2025
Nature

Volume: 641, P: E7
Optical Configuration of Amino-acids in Pre-Cambrian Fig Tree Chert

KEITH A. KVENVOLDEN
ETTA PETERSON
GLENN E. POLLOCK
Research11 Jan 1969
Nature

Volume: 221, P: 141-143
Local cytoplasmic calcium gradients in living mitotic cells

Charles H. Keith
Rajiv Ratan
Michael L. Shelanski
Research29 Aug 1985
Nature

Volume: 316, P: 848-850
Investigative needle core biopsies support multimodal deep-data generation in glioblastoma

Stereotactic needle biopsies are currently performed for diagnosis only in glioblastoma; this study highlights the depth of information available through multi-omics analysis.

Kenny K. H. Yu
Sreyashi Basu
Nathalie Y. R. Agar
ResearchOpen Access28 Apr 2025
Nature Communications

Volume: 16, P: 1-23
Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics

Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive heterogeneity and microenvironmental co-evolution.

Avishay Spitzer
Kevin C. Johnson
Mario L. Suvà
ResearchOpen Access09 May 2025
Nature Genetics

Volume: 57, P: 1168-1178
The multilayered transcriptional architecture of glioblastoma ecosystems

Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with specific mutations that form three stereotypical ecosystems.

Masashi Nomura
Avishay Spitzer
Itay Tirosh
ResearchOpen Access09 May 2025
Nature Genetics

Volume: 57, P: 1155-1167
Climatic warming of the West Antarctic ice sheet

ROBERT H. THOMAS
TIMOTHY J. O. SANDERSON
KEITH E. ROSE
Research23 Oct 1980
Nature

Volume: 287, P: 759-760
Antagonism of Pressure and Anaesthesia

SHEENA M. JOHNSON
KEITH W. MILLER
Research03 Oct 1970
Nature

Volume: 228, P: 75-76
Evidence for Extraterrestrial Amino-acids and Hydrocarbons in the Murchison Meteorite

KEITH KVENVOLDEN
JAMES LAWLESS
CARLETON MOORE
Research05 Dec 1970
Nature

Volume: 228, P: 923-926
A. J. Eisfeld et al. reply

Amie J. Eisfeld
Asim Biswas
Yoshihiro Kawaoka
Research16 Apr 2025
Nature

Volume: 640, P: E28-E29
Detection of an unstable fragment of DNA specific to individuals with myotonic dystrophy

Jessica Buxton
Peggy Shelbourne
Keith Johnson
Research06 Feb 1992
Nature

Volume: 355, P: 547-548
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature

Volume: 578, P: 102-111
Cryptic sites in vinculin

Andrew P. Gilmore
Keith Burridge
News & Views19 Jan 1995
Nature

Volume: 373, P: 197
Expression of topoisomerase II alpha and beta in an adenocarcinoma cell line carrying amplified topoisomerase II alpha and retinoic acid receptor alpha genes

J Coutts
JA Plumb
WN Keith
Research01 Oct 1993
British Journal of Cancer

Volume: 68, P: 793-800
Author Correction: Observation of polarization density waves in SrTiO₃

Gal Orenstein
Viktor Krapivin
Mariano Trigo
Amendments and Corrections22 May 2025
Nature Physics

Volume: 21, P: 1026
Localization of a gene for partial epilepsy to chromosome 10q

Ruth Ottman
Neil Risch
Kirk C. Wilhelmsen
Research01 May 1995
Nature Genetics

Volume: 10, P: 56-60
Practitioner perspectives on informing decisions in One Health sectors with predictive models

Kim M. Pepin
Keith Carlisle
David TS Hayman
ResearchOpen Access21 Jun 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-15
Loss of functional K_ATP channels in pancreatic β–cells causes persistent hyperinsulinemic hypoglycemia of infancy

Charlotte Kane
Ruth M. Shepherd
Mark J. Dunne
Research01 Dec 1996
Nature Medicine

Volume: 2, P: 1344-1347
Uniform distribution of BeO particles in Be casting produced in rocket free fall

G. WOUCH
R. T. FROST
A. E. LORD JR
Research01 Jul 1978
Nature

Volume: 274, P: 235-237
Origin of the expansion mutation in myotonic dystrophy

Georges Imbert
Christine Kretz
Jean-Louis Mandel
Research01 May 1993
Nature Genetics

Volume: 4, P: 72-76
PR55α subunit of protein phosphatase 2A supports KRAS^G12D-driven tumorigenesis that requires YAP activation

Christopher B. Jenkins
Alison L. Camero
Ying Yan
Research26 Jun 2025
Oncogene

P: 1-13
Human lifespan changes in the brain’s functional connectome

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

Lianglong Sun
Tengda Zhao
Yong He
Research03 Apr 2025
Nature Neuroscience

Volume: 28, P: 891-901
Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

Andrew P. Gilmore
Keith Burridge
Research06 Jun 1996
Nature

Volume: 381, P: 531-535
Cloning of the essential myotonic dystrophy region and mapping of the putative defect

Charalampos Aslanidis
Gert Jansen
Pieter J. de Jong
Research06 Feb 1992
Nature

Volume: 355, P: 548-551
Deuterium NMR study of lipid organisation in Acholeplasma laidlawii membranes

GERALD W. STOCKTON
KENNETH G. JOHNSON
MYER BLOOM
Research15 Sept 1977
Nature

Volume: 269, P: 267-268
Broadband phonon mean free path contributions to thermal conductivity measured using frequency ___domain thermoreflectance

Little is known about the mean free path spectra of lattice vibrations—known as phonons—that carry heat in non-metallic solids. Regner et al. demonstrate a technique that enables measurement of these spectra over an unprecedented range, enabling a more complete picture of heat flow in non-metals.

Keith T. Regner
Daniel P. Sellan
Jonathan A. Malen
Research27 Mar 2013
Nature Communications

Volume: 4, P: 1-7
A population-based analysis of the molecular landscape of glioma in adolescents and young adults reveals insights into gliomagenesis

Bennett et al. conducted a population-based study in adolescents and young adults with gliomas, revealing the specific molecular alterations and identifying potential subclassifications and targets.

Julie Bennett
Adrian B. Levine
Cynthia Hawkins
Research07 May 2025
Nature Cancer

Volume: 6, P: 1102-1119
General anaesthetics can selectively perturb lipid bilayer membranes

KEITH W. MILLER
KAM-YEE Y. PANG
Research01 Sept 1976
Nature

Volume: 263, P: 253-255
Detection of crustal deformation from the Landers earthquake sequence using continuous geodetic measurements

Yehuda Bock
Duncan C. Agnew
Frank K. Wyatt
Research28 Jan 1993
Nature

Volume: 361, P: 337-340
Age relationships along the Hermitage Bay–Dover Fault System, Newfoundland

JOHN BLENKINSOP
P. F. CUCMAN
KEITH BELL
Research01 Jul 1976
Nature

Volume: 262, P: 377-378
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Localization of the malignant hyperthermia susceptibility locus to human chromosome 19ql2–13.2

Tommie V. McCarthy
J. M. Sandra Healy
Keith Johnson
Research08 Feb 1990
Nature

Volume: 343, P: 562-564
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Chin Chiang
Ying Litingtung
Philip A. Beachy
Research03 Oct 1996
Nature

Volume: 383, P: 407-413
Learning alters theta-nested gamma oscillations in inferotemporal cortex

Keith Kendrick
Yang Zhan
Jianfeng Feng
ResearchOpen Access24 Apr 2009
Nature Precedings

P: 1
Gene expression analysis by massively parallel signature sequencing (MPSS) on microbead arrays

Sydney Brenner
Maria Johnson
Kevin Corcoran
Research01 Jun 2000
Nature Biotechnology

Volume: 18, P: 630-634
Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans

Julian K.-C. Ma
Ban Y. Hikmat
Thomas Lehner
Research01 May 1998
Nature Medicine

Volume: 4, P: 601-606
Learning alters theta-nested gamma oscillations in inferotemporal cortex

Keith Kendrick
Yang Zhan
Jianfeng Feng
ResearchOpen Access28 Apr 2009
Nature Precedings

P: 1
Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Siew et al. using multi-omic, physiological & imaging approaches have demonstrated that spaceflight causes kidney remodelling, suggesting a contribution to kidney stone formation, & that space radiation causes kidney damage & early signs of dysfunction.

Keith Siew
Kevin A. Nestler
Stephen B. Walsh
ResearchOpen Access11 Jun 2024
Nature Communications

Volume: 15, P: 1-20
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Potential awareness of plants

Keith Roberts
News & Views05 Nov 1992
Nature

Volume: 360, P: 14-15
Pathway and network analysis of more than 2500 whole cancer genomes

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Matthew A. Reyna
David Haan
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-17
Combined burden and functional impact tests for cancer driver discovery using DriverPower

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Shimin Shuai
Federico Abascal
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-12
Integrative pathway enrichment analysis of multivariate omics data

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Marta Paczkowska
Jonathan Barenboim
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-16

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