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Despite advances in polymer science, reversible formation and control of linear conjugation in polymer backbones remain elusive. Now, copolymerizing lactone-functionalized xanthene units with π-conjugated building blocks has been shown to produce polymers capable of reversible, stimuli-responsive conjugation switching, enabling tunable semiconducting behaviour and offering a promising strategy for designing smart, responsive polymeric materials.

Meng et al. demonstrate that RIOK1 phase separation leads to PTEN mRNA sequestration and pentose pathway activation resolving cellular stress in hepatocellular carcinoma. Targeting RIOK1 enhances response to tyrosine kinase inhibitors.

Rice expansion due to crop migration causes over 122% irrigation increases in Northeast China from 2000 to 2020, while climate change reduces irrigation demands by decreased evapotranspiration and increased precipitation, based on a water requirement model using rice maps and groundwater data.

Transition metal oxides can have exotic electronic phases because of the interplay of charge, spin and orbital degrees of freedom. Here, the authors investigate thin films of La_0.7Sr_0.3MnO₃and show a new phase with transport anisotropy under large tensile strain.

The advance in improving the operational lifetime of organic solar cells is currently limited. Here, the authors report a radical scavenger capped zinc oxide nanoparticles as the electron transport layer, achieving operationally stable devices with efficiency of 19.47%.

Here, the authors use cryo-EM to show that phosphorylating or O-GlcNAcylating α-synuclein on serine 87 leads to the formation of two distinct fibril structures. Both structures display reduced neurotoxicity and propagation activity.

Non-alcoholic steatohepatitis (NASH) has received great attention due to its high incidence, but the underlying mechanism remains poorly understood. Here, the authors show LAPTM5 expression ameliorates NASH and can potentially serve as a biological marker indicative of NASH progression.

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s  = 13 TeV and an integrated luminosity of 140 fb⁻¹.

A self-assembled monolayer of (4-(7H-dibenzo[c,g]carbazol-7-yl)butyl)phosphonic acid is integrated in wide-bandgap perovskite solar cells, which enables a high power conversion efficiency and low open-circuit voltage deficiency, as well as efficient centimetre-scale all-perovskite tandem solar cells.

A transcriptome-wide association study identifies associations of genetically predicted gene expression with breast cancer risk. This analysis finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci.

The Chinese tree shrew, Tupaia belangeri chinensis, has been proposed as a potential animal model in biomedical research and drug safety testing. This study presents the full genome of the Chinese tree shrew, identifying common features between the tree shrew and primates.

Zhu et al. develop a low-cost donor–acceptor-type hole-selective layer that minimizes interfacial non-radiative charge recombination losses in single-junction and tandem solar cells based on metal halide perovskites with different bandgaps.

A cross-sectional study of hospitalized patients with COVID-19 and a longitudinal follow-up study of patients with COVID-19 suggest that SARS-CoV2-specific IgG or IgM seroconversion occurs within 20 days post symptom onset.

This study analyses radio observations of the jet in galaxy M87, from which the existence of a spinning black hole that induces Lense–Thirring precession of a misaligned accretion disk is inferred.

Activating mutations of BRAF alone are inadequate to drive melanoma formation. Here the authors show that activation of Hippo signalling by oncogenic BRAF represents an additional safeguard to limit BRAF-dependent human melanocyte growth and melanoma formation.

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

While converting water to H₂ with a catalyst offers a renewable means to produce carbon-neutral fuels, understanding the catalytic active sites has proven challenging. Here, authors show a structurally well-defined model complex with Pt-O bonding to enable efficient H₂ evolution electrocatalysis.

Epigenetic and genetic factors have a role in obesity but the role of epigenetics in this disease is unclear. Here, Liet al. investigated global DNA methylation patterns in three breeds of pigs that have different fat contents, providing a resource for the further analysis of differentially methylated gene promoters in obesity.

Atom trapping is a well-established route to prepare single-atom catalysts. Here the authors propose a reverse atom-trapping strategy in which surface strontium atoms of LSCF fuel cell cathodes are extracted by MoO₃, forming single strontium vacancies on LSCF in a controllable manner and tuning its performance for the oxygen reduction reaction.

A quantitative atlas of the transcriptomes, proteomes and phosphoproteomes of 30 tissues of the model plant Arabidopsis thaliana provides a valuable resource for plant research.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

Following our call to join in the discussion over the suitability of implementing a reporting checklist for bio–nano papers, the community responds.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

This study reveals that adhesion molecule ICAM-1 is markedly upregulated in the aorta after angiotensin II infusion. Blockage of soluble ICAM-1 prevents Ang II-induced arterial hypertension and vascular remodeling by reducing macrophage adhesion, suggesting that targeting ICAM-1 may represent a new therapeutic target for hypertension.

Interferon-γ induces ferroptotic cell death in tumours by suppressing cystine uptake and promoting lipid peroxidation.

The complement system has a key role in inflammatory reactions that occur before, during and after transplantation. Here, the authors discuss this role and highlight current and future strategies to regulate complement activation and potentially improve outcomes in kidney transplantation.

Jianquan Liu and colleagues report the draft genome sequence of the domestic yak, Bos grunniens. Their comparative analyses with low-altitude cattle provide insights into high-altitude adaptation in the yak.