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Broad and potent neutralizing antibodies to SARS-CoV-2 variants can be efficiently identified via accurate deep-mutational-scanning-based prediction of viral evolution and delivered to mice using mRNA–lipid nanoparticles.

Fusarium crown rot disease threatens wheat yields. Here, the authors report roles for wheat TaSnRK1α and a catalase antioxidant enzyme in mediating Fusarium crown rot resistance by scavenging reactive oxygen species in wheat plants.

Propane dehydrogenation is challenging to perform under mild conditions due to the reaction’s endothermic nature. Now, near-ambient propane dehydrogenation has been shown using copper single-atom catalysts supported on titanium oxide under light illumination and a water vapour environment.

Dynamic nanodomains in lead halide perovskites, dictated by A-site cations, crucially affect the optoelectronic properties by modulating electronic disorder and consequently enabling better solar cells and optoelectronic devices.

A strategy is introduced for promoting the folding in metallopeptide nanostructures, resulting in high mechanical rigidity. The mechanical properties are reflected in enhanced peptide-binding properties and heightened antimicrobial activities relative to their unfolded counterparts.

Effectively delivering medications to the renal tubule to delay or halt chronic kidney disease progression remains a significant unmet clinical challenge. Here, authors introduce an innovative strategy for renal tubule targeting using biomimetic high-density lipoprotein (bHDL) nanoparticles.

Sun et al. report human lifespan changes in the brain’s functional connectome in 33,250 individuals, which highlights critical growth milestones and distinct maturation patterns and offers a normative reference for development, aging and diseases.

The study assembled a chromosome-level genome of Cycas panzhihuaensis, the last major lineage of seed plants for which a high-quality genome assembly was lacking. The study closes an important gap in our understanding of genome structure and evolution in seed plants.

The FarmGTEx Project aims to understand genetic control of gene activity under diverse biological and environmental contexts in domestic animals, providing a foundation for improving animal precision breeding, adaptation and human health.

A dual-functional phage protein can both modulate bacterial host behaviour and promote phage genome packaging, ensuring successful propagation and pointing towards phage therapy applications.

Cold tolerance has lost during tomato natural evolution. Here, the authors report that absence of a 60 bp promoter fragment in the WRKY34 gene results in loss of cold tolerance in domesticated tomato varieties, and reveal how this natural variation can affect cold tolerance.

The molecular pathways regulating the cardioprotective activity of deacetylase sirtuin-1 are unknown. Here, Yanget al. show that histone H3K9 methyltransferase SUV39H and HP1gamma cooperatively methylate H3K9 on the sirtuin-1 promoter and inhibit sirtuin-1 transcription, and show that inhibition of SUV39H in mice is cardioprotective.

Breeding crop cultivars with better environmental adaptability could support crop yield stability to mitigate the effects of climate change. Combining transcriptional dynamics of florigen genes and statistical models, the daylength-sensing-based environment adaptation simulator can forecast the latitude adaptability of rice cultivars and has application potential in other crops.

The uterine stroma only fully differentiates postnatally, but how this is regulated remains unclear. Here they show that postnatal uterine stromal development is mediated at an epigenetic level by PRSET7, which represses interferon response genes.

The pilot phase of PigGTEx, re-analyzing 5,457 published RNA-seq samples, presents a pan-tissue catalog of molecular quantitative trait loci. Cross-species comparisons identify traits with shared genetic regulation in humans.

Single-atom catalyst (SAC) has emerged as a frontier in heterogeneous catalysis yet its robustness remains a critical concern. Here, a highly active, selective and robust Ru₁-N₃ SAC is explored for a challenging reaction, reductive amination of aldehydes/ketones for synthesis of primary amines.

The authors perform a genome-wide association study of adolescent idiopathic scoliosis patients of Han Chinese descent, and identify 3 new loci for disease susceptibility.

Signet-ring cell carcinoma (SRCC) is a unique type of gastric cancer with no prognostic features. Here, the authors report a CLDN18-ARHGAP26/6 gene fusion in patients with a high signet-ring cell content, poor survival outcomes, and who experience no benefit from platinum/fluoropyrimidines-based chemotherapy.

Alternative splicing plays a major role in the generation of functional diversity but the underlying mechanisms remain poorly understood. In a comparative genome analysis of 73 arthropod species, spanning around 420 million years of evolution, Yongfeng and coworkers find built-in intronic elements that lead to mutual exclusive splicing. These elements are species- or clade-specific, but evolutionarily conserved at the secondary structure level.

The mechanism of parturition initiation remains elusive. Here, authors show that epithelium is an underestimated site for parturition initiation via epithelial PGF2a regulated by SHP2-COX1/COX2.

RNA editing and circRNAs are involved in tumorigenesis. Here the authors report that ADARs regulate the circular transcriptome in a bidirectional manner through and beyond their editing function in multiple cancer cells.

Chan et al. report that 3′ UTR splicing is widespread and enhanced across different cancer types and is associated with more advanced tumour progression.

Alternative splicing at the Drosophila Down syndrome cell adhesion molecule gene generates 38,016 isoforms, and underlies self-avoidance of growing neurons. Wang et al. identify a structure in the DSCAM mRNA that ensures mutually exclusive splicing and observe expansion of the structure with increasing number of exons during arthropod evolution.

Based on differently-oriented MAPbBr3 single-crystal wafers, the authors revealed anisotropic carrier dynamics by using angle-resolved pump-probe technique, and the microstructural mechanism of the femtosecond laser-induced emission enhancement

Synergizing metal–support interactions and spatial confinement through atomic copper grippers boost the dynamics of highly loaded atomic nickel for high activity, high thermal/chemical stability and unprecedented coke inhibition in hydrogenation reactions.

Lusheng Huang, Jun Ren and colleagues report the genome sequences of 69 pigs, representing 11 geographically distinct breeds and 3 wild boar populations, from within China. They identify loci related to high- and low-latitude adaptation and infer a likely ancient introgression event in northern Chinese pigs.

The synthesis of nitrogen-containing heterocycles from biomass is scarcely known. Here, the authors report a strategy for the N-heterocyclic piperidines synthesis by one-pot amination of the bio-based furfural utilizing a Ru₁Co_NP/HAP surface single-atom alloy catalyst.

Polygenic Risk Scores (PRS) show promise for facilitating cancer risk stratification. Here, the authors performed a large genome-wide association study and develop a PRS for nasopharyngeal carcinoma, which could improve risk stratification and personalized screening.

RNA binding proteins (RBPs) can participate in regulatory networks to control alternative splicing. Here the authors show that DAP3 functions as an RBP splicing modulator via two mechanisms, and that its overexpression leads to mis-splicing events in cancers.

RNA editing and RNA splicing are involved in tumorigenesis. Here the authors report crosstalk between RNA editing and splicing by identifying ADAR1/2-dependent splicing events in esophageal squamous carcinoma cells.

Designing ultrathin and flexible antenna is of great interest for efficient wireless data communication and transmission at fast-growing IoT applications. The authors report a flexible ultrawideband Ti₃C₂ monopole antenna by combining strategies of interfacial modification and advanced extrusion printing technology.

Reduction of nitroarenes in the presence of other reducible groups is challenging, as is simultaneously achieving high selectivity and activity. Here, the authors report supported single-atom and pseudo-single-atom platinum catalysts with excellent activity and high degrees of chemoselectivity.

Timothy Vyse, Yong Cui, Wanling Yang and colleagues report a meta-analysis of genome-wide association studies for systemic lupus erythematosus (SLE) including European and Chinese individuals. They identify ten new loci associated with SLE and find evidence for increased genetic risk of disease among individuals of non-European ancestry.

The use of perovskite quantum-wire light emitters results in high-quality planar and spherical light-emitting diodes.

The UBXN proteins are likely involved in a diverse range of biological processes, but their physiological functions remain largely unknown. Here the authors show that UBXN3B positively regulates STING-mediated immune responses in the context of viral infections.

A set of in situ and operando techniques, as well as gravimetric and microscopic investigations are used to characterize the formation of the solid–electrolyte interphase in a Li-ion battery.