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A reinforcement learning-based virtual reality system, implementing a series of sport sessions with coaching, was as effective as standard physical activity in reducing fat mass in adolescents, with positive effects on cognition.

Li et al. report free-standing layered polymer–perovskite composite membranes that reconcile mechanical flexibility with electronic properties. They endure 30,000 bends at a 1.5 mm radius, enabling wearable radiation monitoring in complex conditions.

The mechanism of macrophage cytotoxicity against cancer cells requires further illustration. By employing CRISPR screening in CAR-macrophage and cancer cell co-culture system, the authors identify depletion of ATG9A on cancer cells sensitizes them to macrophage-mediated killing, which can be synergic with CSF1R inhibition in cancer treatment.

Electronic wound bandages have to balance conformability and wound healing properties. Here, the authors develop a smart patch (iSAFE) using biomaterials with bioelectronics to facilitate permeability with waterproofing. This achieves intelligent wound management with real-time wound monitoring and active therapy.

TRPML2, a lysosomal TRP channel, regulates endolysosomal integrity and chemokine secretion. This work reports the cryo-EM structures of TRPML2 in multiple states bound to modulators revealing its diverse regulatory mechanisms among ion channels.

While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

Short-lived halogens have a substantial indirect cooling effect on climate and this cooling effect has increased since pre-industrial times owing to anthropogenic amplification of natural halogen emissions.

Suppressing charge transport and reducing conduction loss at high temperatures and electric fields is crucial in high-temperature dielectric materials. Here, the authors incorporate high-polarity small molecules into polyetherimide to increase its energetic disorder and reduce charge transport, enabling an energy density of 6.45 J cm-3 with an efficiency of 90%.

Fanjiang Kong, Zhixi Tian, Xingliang Hou, Baohui Liu and colleagues report the cloning and functional characterization of J, the locus underlying the long-juvenile (LJ) trait that has enabled tropical cultivation of soybean. They show that J, an ortholog of Arabidopsis ELF3, downregulates the expression of E1, thereby promoting flowering under short-day conditions.

Neural circuit mechanisms underlying feeding behavior regulation are not fully understood. Here authors provide quantitative mapping of the brain-wide input and output configuration of tuberal nucleus somatostatin neurons, a key player of feeding regulation, in mouse brain for a deeper understanding of the feeding regulation network.

The antibacterial agent colistin displays synergistic activity with azoles and echinocandins against various pathogenic fungi. Here, the authors show that the mechanisms involve disruption of cell membrane permeability and calcium homeostasis.

Ultrafast magnetic resonance spectroscopic imaging enables non-invasive high-resolution metabolic imaging of the whole human brain under healthy and diseased conditions.

Authors use a high-entropy engineering approach to produce fully amorphous BiTO films by exfoliation and annealing, creating crystalline regions, leading to flexible ceramics with dielectric properties.

Arising from singularity on the surface of Poincaré sphere, topology-protected phase for co-polarized light enables 2π phase modulation, which complements the classical cross-polarized Pancharatnam-Berry phase and expands the versatility of flat optics.

Controlling droplet motion after impact on solid surfaces is crucial for applications like self-cleaning and microfluidics, yet the fundamental limit of the droplet rebound angle remains unknown. This study reveals a droplet behavior where it rapidly rolls with a rebound angle near zero, defining the lower limit, enabled by asymmetric adhesion on nanostructured surfaces, resulting in greatly enhanced cleaning efficiency and precise droplet transport.

The authors present a 3.5-million-year-long pollen record from the Zoige Basin of the eastern Tibetan Plateau, 3,442 m above sea level. The ~5,000 pollen assemblages retrieved from the core reveal many ecosystem transitions during this time and, when correlated with climatic curves, indicate what effects future warming may have on regional vegetation.

Hexagonal boron nitride (h-BN) encapsulation is important to improve the performance of graphene devices, but it is normally restricted by exfoliation and transfer methods. Here, the authors report the conformal h-BN encapsulation for the hierarchical configuration of large-scale graphene-skinned glass fiber fabrics via chemical vapor deposition, leading to improved electrical and thermal stability.

Designing efficient power and communication electronics remains a challenge. Here, the authors reveal info characteristics of power electronics and propose a modulation strategy based on frequency hopping-differential phase shift keying to enable power converter design integrated with communication.

The authors show that NAT10 is upregulated with T cell antigen receptor signaling and that T cell-specific NAT10 deficiency results in diminished numbers of naive T cells, translating to an inability to mount a significant antiviral T cell response.

Anode-free lithium batteries are hindered by lithium inventory loss from parasitic interfacial reactions, cathode degradation, and limited Li⁺ reversibility. Here, authors propose a prelithiation separator engineering to enable multiscale interfacial stabilization in Ah-class anode-free pouch cells.

In-situ harvesting of wave energy can provide a continuous energy supply for oceanic unmanned equipment. Here, the authors develop a pendulum-based nanogenerator that efficiently converts disordered waves into electricity for self-powered, distributed marine monitoring networks.

Nonlinear transport has recently been shown to allow efficient detection of the Néel vector, however, antiferromagnets hosting nonlinear transport are assumed rare, due to the required strong spin-orbit coupling. Here, Zhu, Li and coauthors find that the magnetic order itself can yield large nonlinear transport.

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Wireless information security has garnered significant attention with the ever-increasingly widespread adoption of broadcast wireless communication systems. Here, authors design and experimentally verify a novel physical-layer secure communication scheme that relies on an information metasurface which is dynamically modulated by chaotic patterns

XPR1 is the only known organic phosphate exporter. Here, authors report the cryo-EM structures of XPR1 in two distinct states, demonstrating its structural analogy to ion-translocating rhodopsins and the possible mechanism of gating.

Zinc is an essential micronutrient for plants, however its excess causes cellular damage. Here, the authors report that natural variation of Trichome Birefringence (TBR) gene confers zinc toxicity tolerance through modulating root cell wall pectin methylesterification in Arabidopsis.

Organic batteries are promising for sustainable energy storage but face challenges in performance and cost. Here, authors develop pressurized organic electrodes with high capacity and durability under practical and extreme conditions, advancing organic batteries toward real-world applications.

Topological polar textures in moiré ferroelectrics have been theoretically predicted but lacked experimental confirmation. Here, the authors observe alternating out-of-plane polarization in ___domain regions and vortex-like inplane polarization patterns at ___domain wall boundaries, indicative of a network of merons and antimerons.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

The authors find that Ag-rich nanoprecipitates with sizes up to tens of nanometers can be formed in metallic Ag/Ag₂Se composite flexible films after spark plasma sintering. Moreover, Ag-rich nanoprecipitates play a positive role in increasing the carrier concentration, enhancing the density-of-states effective mass, and mitigating carrier scattering.

Legionella effector LnaB, a recently identified actin-activated AMPylase, mediates phosphoryl-AMPylation in a yet-unknown manner. Here the authors unveil a two-step catalytic process involving dual ATPase–AMPylase activity based on structural studies, providing a biochemical basis for AMPylation.

Pei et al. overcome desorption of passivating molecules under photothermal stress in wide-bandgap perovskites and achieve perovskite/Cu(In,Ga)Se₂ tandem solar cells with a certified efficiency of 27.35%.

Antiferromagnets have a variety of attractive features for spintronic devices; they are inherently robust against external magnetic fields, and have fast, terahertz, dynamics. However, terahertz magnons are usually strongly damped. Here, Choe, Lujan and coauthors find that the zone boundary magnons in the AFM insulator CoTiO3 exhibit long lifetimes.

Complex traits present challenges for gene mapping and molecular characterization. Here, the authors develop a 16-generation intercross line of chickens to explore the genetic architecture of complex traits in chicken.

Single-cell and spatial transcriptomics analysis of stricturing Crohn’s disease highlights cellular heterogeneity in fibrotic tissue and identifies neighborhoods of fibroblasts and immune cells contributing to this severe disease complication.

Stress stimulation-mediated liquid-liquid phase separation is an essential feature of living organisms, but its biophysical characteristics are poorly understood. Here, the authors report a UV-light stress stimulation behaviour in a binary community of synthetic protocells of condensates and proteinosomes, showing that condensates could behave like condensate pumps to enable a stepwise controlled transmembrane mass transfer regardless of the permeability barrier of proteinosomes.

Two genetically linked TdNLR genes from wild emmer wheat are both required for YrTD121-mediated stripe rust resistance. The TdNLR1 and TdNLR2 pair lacks an integrated ___domain, representing an uncommon architecture for paired NLRs in plants.

Chiral state transfer typically requires nonadiabatic transitions and ultra-complex experimental control. Here, authors demonstrate a new mechanism arising from basins of attraction, enabling nonlinear chiral-like state transfer with a minimal set of parameters.

2D Ta-based transition metal dichalcogenides have been predicted to host highly confined plasmons, but their observation has been lacking. Here, the authors report momentum-resolved electron energy loss spectroscopy measurements of 2H-TaS₂ monolayers and bilayers, showing plasmon resonances with lateral confinement up to 300 and group velocity down to ~10⁻⁴c at large wave vectors.

Low-surface-energy crystal planes are effective in suppressing dendritic growth and parasitic side reactions. Here, authors demonstrate that [112 ̅0]-oriented zinc metal negative electrodes with high surface energy can also achieve sustained epitaxial growth.

A three-dimensional metal stamp can be used to selectively exfoliate two-dimensional materials, allowing the remaining material to be patterned into two-dimensional arrays without leaving chemical or polymer residues.

The influence of Li occupancy on electro-chemomechanical stability in Co-free Ni-rich layered oxides for Li-ion batteries has been overlooked. Here, authors investigate different Li structural units in the oxide lattice and show that tuning the Li occupancy improves battery cycling stability.

The neurotransmitter serotonin regulates cancer through receptor-signaling activation, but also epigenetics mechanisms by serotonylation. Here, the authors show that histone serotonylation promotes pancreatic cancer progression by upregulating stearoyl-CoA desaturase (SCD), which remodels lipid metabolism, suggesting a potential target for therapy.

Piezoelectric materials for bone repair usually require scaffold filling and external stimulation. Here, the authors present a self-reinforced chip that can spontaneously generate piezoelectric effect under physiological vibrations to achieve scaffold-free repair of critical-sized bone defects