Nature Search

Structural basis of RNA polymerase complexes in African swine fever virus

The African swine fever virus represents a threat to global pig production. Here, the authors determine the cryo-EM structures of ASFV RNA polymerase, and suggest that the M1249L subunit may modulate polymerase activity in cells.

Guoliang Zhu
Fei Xi
Haixue Zheng
ResearchOpen Access08 Jan 2025
Nature Communications

Volume: 16, P: 1-13
An integrated large-scale photonic accelerator with ultralow latency

A large-scale photonic accelerator comprising more than 16,000 components integrated on a single chip to process MAC operations is described, demonstrating ultralow latency and reduced computing time compared with a commercially available GPU.

Shiyue Hua
Erwan Divita
Yichen Shen
ResearchOpen Access09 Apr 2025
Nature

Volume: 640, P: 361-367
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation

Yongbo Luo
Youmiao Zeng
Chaohui Gu
Research01 Jul 2025
Oncogene

P: 1-17
In situ energetics modulation enables high-efficiency and stable inverted perovskite solar cells

The introduction of 3TPYMB, an n-type molecule into inverted perovskite solar cells, enables a power conversion efficiency of 25.6%, with devices maintaining up to 98% of the initial efficiency after 1,800 h of operation.

Hongwei Zhu
Bingyao Shao
Osman M. Bakr
Research02 Oct 2024
Nature Photonics

Volume: 19, P: 28-35
Publisher Correction: Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer

Hongmiao Wang
Huixun Jia
Zheng-Jiang Zhu
Amendments and CorrectionsOpen Access19 Jan 2023
Nature Communications

Volume: 14, P: 1
Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment

The effects of Schwann cells on the neuro-stroma niche in pancreatic ductal adenocarcinoma (PDAC) remain to be explored. Here, single-cell RNA-sequencing and spatial transcriptome analysis of PDAC tissues reveal that Schwann cells induce malignant subtypes of tumour cells and cancer associated fibroblasts.

Meilin Xue
Youwei Zhu
Hao Chen
ResearchOpen Access31 Jul 2023
Nature Communications

Volume: 14, P: 1-18
Targeting p97–Npl4 interaction inhibits tumor T_reg cell development to enhance tumor immunity

Tumor-infiltrating regulatory T (TI-T_reg) cells help tumor growth by suppressing local immune responses. Here the authors show that thonzonium bromide can help fight tumors by interfering with the interaction of p97 and Npl4, a complex that they show supports TI-T_reg cells.

Pingping Nie
Zhifa Cao
Zhaocai Zhou
Research06 Aug 2024
Nature Immunology

Volume: 25, P: 1623-1636
Neoadjuvant chemotherapy with or without camrelizumab in resectable esophageal squamous cell carcinoma: the randomized phase 3 ESCORT-NEO/NCCES01 trial

In a randomized phase 3 trial, neoadjuvant anti-PD-1 plus either paclitaxel and cisplatin or nab-paclitaxel and cisplatin elicited a significantly superior pathological complete response rate versus neoadjuvant paclitaxel and cisplatin alone in patients with resectable locally advanced esophageal squamous cell carcinoma.

Jianjun Qin
Liyan Xue
Yin Li
ResearchOpen Access02 Jul 2024
Nature Medicine

Volume: 30, P: 2549-2557
Serum metabolic traits reveal therapeutic toxicities and responses of neoadjuvant chemoradiotherapy in patients with rectal cancer

Neoadjuvant chemoradiotherapy is the standard treatment for patients with locally advanced rectal cancer, however, response can be limited by development of toxicities. Here, the authors conducted metabolomics on patients with locally advanced rectal cancer enrolled in a phase III clinical study and identify serum metabolites associated with treatment response.

Hongmiao Wang
Huixun Jia
Zheng-Jiang Zhu
ResearchOpen Access17 Dec 2022
Nature Communications

Volume: 13, P: 1-14
Modulation of histone acetylation enables fully mechanized hybrid rice breeding

The manual-labour-intensive hybrid seed production process is a limiting step for fully mechanized hybrid rice breeding. This work demonstrates that the use of ideal small-grain alleles of GSE3 enables fully mechanized hybrid rice breeding.

Ke Huang
Yuexing Wang
Yunhai Li
Research03 Jun 2024
Nature Plants

Volume: 10, P: 954-970
Light-independent phytoplankton degradation and detoxification of methylmercury in water

This research reveals a previously unrecognized yet potentially widespread biological pathway of methylmercury detoxification, which may exert important controls on the net production and bioaccumulation of the methylmercury toxin in aquatic food webs.

Xujun Liang
Huan Zhong
Baohua Gu
Research07 Aug 2023
Nature Water

Volume: 1, P: 705-715
Current evidence on the relationships among five polymorphisms in the matrix metalloproteinases genes and prostate cancer risk

Jiandong Gui
Hangsheng Zhou
Yuanyuan Mi
ResearchOpen Access18 May 2024
Scientific Reports

Volume: 14, P: 1-9
Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy

“Satellite cells are crucial for skeletal muscle regeneration. Here the authors show that immunoglobulin superfamily containing leucine-rich repeat (Islr) promotes skeletal muscle regeneration via a mechanism involving Dishevelled-2 stabilization in satellite cells and protection from autophagy.

Kuo Zhang
Yuying Zhang
Qingyong Meng
ResearchOpen Access03 Dec 2018
Nature Communications

Volume: 9, P: 1-16
Cumulative damage characteristics of tunnel initial support concrete under blasting load

Yan Zhao
Zhuang Zhang
Mingzan Yu
ResearchOpen Access23 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Epitaxial growth of inch-scale single-crystal transition metal dichalcogenides through the patching of unidirectionally orientated ribbons

Here, the authors report the direct growth of periodic arrays of 2D semiconductor ribbons by exploiting the step edges of high-miller-index Au facets, showing potential for 2D electronic devices. The synthesized ribbons could also be merged to obtain wafer-scale single-crystal monolayers.

Pengfei Yang
Dashuai Wang
Yanfeng Zhang
ResearchOpen Access10 Jun 2022
Nature Communications

Volume: 13, P: 1-9
Atomic-scale insights on hydrogen trapping and exclusion at incoherent interfaces of nanoprecipitates in martensitic steels

By trapping hydrogen, nanoprecipitates can mitigate the hydrogen embrittlement of high strength steels. Here, the authors report direct evidences on the structural and chemical features underlying distinct hydrogen-trapping behaviors at the incoherent interfaces of precipitates and steel matrix.

Binglu Zhang
Qisi Zhu
Lijie Qiao
ResearchOpen Access05 Jul 2022
Nature Communications

Volume: 13, P: 1-11
Rational design of isostructural 2D porphyrin-based covalent organic frameworks for tunable photocatalytic hydrogen evolution

Covalent organic frameworks (COFs) present well-defined materials for constructing structure-property-activity relationships. Herein, authors explore isostructural porphyrinic two-dimensional COFs with tunable of photocatalytic H₂ production rates arising from tailored charge-carrier dynamics.

Rufan Chen
Yang Wang
Cheng Wang
ResearchOpen Access01 Mar 2021
Nature Communications

Volume: 12, P: 1-9
Laparoscopic-based perivascular unilateral renal sympathetic nerve denervation for treating resistant hypertension: a case report

Chuanyu Gao
Linwei Zhao
Jiguang Wang
ResearchOpen Access27 Feb 2019
Hypertension Research

Volume: 42, P: 1162-1165
Artificial photosynthesis of oxalate and oxalate-based polymer by a photovoltaic reactor

Guangzai Nong
Shan Chen
Shuangfei Wang
ResearchOpen Access06 Jan 2014
Scientific Reports

Volume: 4, P: 1-7
OPN gene polymorphisms, rs17524488 GG/G, rs11730582 T/C and rs9138 C/A and cancer risk in a Chinese population

Yuanyuan Mi
Kewei Ren
Ninghan Feng
ResearchOpen Access15 Sept 2015
Scientific Reports

Volume: 5, P: 1-10
4D printing smart biomedical scaffolds with novel soybean oil epoxidized acrylate

Shida Miao
Wei Zhu
Lijie Grace Zhang
ResearchOpen Access02 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
Mechanically and biologically skin-like elastomers for bio-integrated electronics

Designing biodegradable and biocompatible polymers to mimic both mechanical and biological properties of skins for emerging electronic devices remains a challenge. Here, the authors propose PSeD-U skin-like elastomers with both mechanical and biological properties for bio-integrated electronics.

Shuo Chen
Lijie Sun
Zhengwei You
ResearchOpen Access27 Feb 2020
Nature Communications

Volume: 11, P: 1-8
Multi-omics reveals the role of ENO1 in bladder cancer and constructs an epithelial-related prognostic model to predict prognosis and efficacy

Zhixiong Su
Lijie You
Zhenhua Liu
ResearchOpen Access25 Jan 2024
Scientific Reports

Volume: 14, P: 1-18
Downregulation of B7-H4 suppresses tumor progression of hepatocellular carcinoma

Lijie Dong
Lulu Xie
Mingdong Zhao
ResearchOpen Access16 Oct 2019
Scientific Reports

Volume: 9, P: 1-12
A meta-analysis of performance advantages on athletes in multiple object tracking tasks

Hui Juan Liu
Qi Zhang
Jie Li
ResearchOpen Access29 Aug 2024
Scientific Reports

Volume: 14, P: 1-15
Synergistic Effect of Cold Atmospheric Plasma and Drug Loaded Core-shell Nanoparticles on Inhibiting Breast Cancer Cell Growth

Wei Zhu
Se-Jun Lee
Lijie Grace Zhang
ResearchOpen Access26 Feb 2016
Scientific Reports

Volume: 6, P: 1-11
Improved Human Bone Marrow Mesenchymal Stem Cell Osteogenesis in 3D Bioprinted Tissue Scaffolds with Low Intensity Pulsed Ultrasound Stimulation

Xuan Zhou
Nathan J. Castro
Lijie Grace Zhang
ResearchOpen Access06 Sept 2016
Scientific Reports

Volume: 6, P: 1-12
Dynamic assessment of measurable residual disease in favorable-risk acute myeloid leukemia in first remission, treatment, and outcomes

Sijian Yu
Tong Lin
Qifa Liu
ResearchOpen Access06 Dec 2021
Blood Cancer Journal

Volume: 11, P: 1-9
Loss of A20 in BM-MSCs regulates the Th17/Treg balance in Rheumatoid Arthritis

Zhuan Feng
Yue Zhai
Ping Zhu
ResearchOpen Access11 Jan 2018
Scientific Reports

Volume: 8, P: 1-11
A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways

Zhibin Zhang
Xi Lin
Fei Xu
ResearchOpen Access05 Jan 2024
Cell Discovery

Volume: 10, P: 1-17
Copper-catalyzed alkyne oxidation/Büchner-type ring-expansion to access benzo[6,7]azepino[2,3-b]quinolines and pyridine-based diones

Organic molecules containing seven-membered rings are important structural motifs for drug candidates, but the construction of seven-membered rings can be challenging through traditional cyclization pathways. Here, the authors report a copper-catalyzed alkyne oxidation and Büchner-type ring-expansion to generate benzo[6,7]azepino[2,3-b]quinolines and pyridine-based diones.

Xiao-Lei Jiang
Qing Liu
Wen-Bo Shen
ResearchOpen Access20 Feb 2023
Communications Chemistry

Volume: 6, P: 1-12
Histone deacetylase HDAC4 participates in the pathological process of myocardial ischemia-reperfusion injury via MEKK1/JNK pathway by binding to miR-206

Qingman Li
Lijie Zhu
Chuanyu Gao
ResearchOpen Access15 Sept 2021
Cell Death Discovery

Volume: 7, P: 1-10
Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow

Fengchan Li
Kunmin Yan
Li Zhu
ResearchOpen Access16 Jul 2021
Cell Death Discovery

Volume: 7, P: 1-14
Isolation and identification of induced systemic resistance determinants from Bacillus simplex Sneb545 against Heterodera glycines

Zhifu Xing
Xiaojing Wu
Yuxi Duan
ResearchOpen Access14 Jul 2020
Scientific Reports

Volume: 10, P: 1-15
In vitro evaluation of Penicillium chrysogenum Snef1216 against Meloidogyne incognita (root-knot nematode)

Aatika Sikandar
Mengyue Zhang
Yuxi Duan
ResearchOpen Access20 May 2020
Scientific Reports

Volume: 10, P: 1-9
High-Performance Photodiode-Type Photodetectors Based on Polycrystalline Formamidinium Lead Iodide Perovskite Thin Films

Meng Zhang
Fan Zhang
Feng Teng
ResearchOpen Access24 Jul 2018
Scientific Reports

Volume: 8, P: 1-9
A novel long noncoding RNA PGC1β-OT1 regulates adipocyte and osteoblast differentiation through antagonizing miR-148a-3p

Hairui Yuan
Xiaowei Xu
Baoli Wang
Research06 Feb 2019
Cell Death & Differentiation

Volume: 26, P: 2029-2045
A high performance lithium ion capacitor achieved by the integration of a Sn-C anode and a biomass-derived microporous activated carbon cathode

Fei Sun
Jihui Gao
Yukun Qin
ResearchOpen Access03 Feb 2017
Scientific Reports

Volume: 7, P: 1-10
The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions

Dayun Yan
Haitao Cui
Michael Keidar
ResearchOpen Access30 Jun 2017
Scientific Reports

Volume: 7, P: 1-12
The Strong Cell-based Hydrogen Peroxide Generation Triggered by Cold Atmospheric Plasma

Dayun Yan
Haitao Cui
Michael Keidar
ResearchOpen Access07 Sept 2017
Scientific Reports

Volume: 7, P: 1-9
Establishment and characterization of esophageal squamous cell carcinoma patient-derived xenograft mouse models for preclinical drug discovery

Jingchuan Zhang
Dongxian Jiang
Qun Wang
Research07 Jul 2014
Laboratory Investigation

Volume: 94, P: 917-926

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