The mammalian HRD1 ubiquitin ligase mediates ERAD of misfolded proteins in the ER. Here, the authors determined cryo-EM structures of human HRD1-SEL1L-XTP3B complexes with and without Derlins, offering insights into glycan recognition and revealing dramatic Derlin-induced conformational changes.
- Liling Guo
- Guoyun Liu
- Hongwu Qian
