The monofluoromethyl (CH2F) motif is valuable as it can mimic CH3 and CH2OH motifs frequently found in bioactive molecules, but the synthesis of N-CH2F amides is challenging. Now the synthesis of numerous N-CH2F amides has been achieved via successive acylation and fluorination of imines, enriching pathways for N-methylation of biomolecules.
- Min Tao
- Jiasheng Qian
- Jianbo Liu
