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Clear cell renal cell carcinoma (ccRCC) usually metastasizes to the lungs. Here, the authors discover that SWI/SNF ATPase subunit SMARCA4 silencing of HLF regulates ccRCC lung metastasis by modulating the integration of collagen's mechanical cues with the actin cytoskeleton through leupaxin.

Targeted deletion of integrin-associated protein CD47 enhances long-term engraftment of human CD34⁺ cells in immunodeficient pigs lacking IL2RG and RAG2, enabling large-scale production of functional human immune cells.

In this work, authors design novel protein condensation inhibitors (PCIs) targeting an allosteric site of cGAS, blocking DNA interactions and phase separation to suppress immune activation, and demonstrate therapeutic potential in inflammatory disease models.

Tracing cellular changes in complex biological systems is challenging. Here, authors present a flexible framework that integrates multi-sample data with in-house algorithms to infer comparative and spatiotemporal cell-gene patterns, advancing understanding of cellular dynamics.

Interferon-γ (IFNγ)-activated calcium/calmodulin-dependent protein kinase II (CAMK2) phosphorylates phosphoserine aminotransferase 1 (PSAT1) at serine 337 (S337), enabling glutathione peroxidase 4 (GPX4) interaction, promoting α-ketoglutarate-dependent PHD3-mediated GPX4 proline 159 (P159) hydroxylation and stabilizing GPX4 to counteract ferroptosis.

Duan, Hu, Han, Lei, Wang et al. report that ADSL-mediated production of fumarate suppresses STING activation and impairs T cell and NK cell infiltration, thereby facilitating immune evasion in breast cancer.

Propane dehydrogenation is an important reaction for the production of propylene, although effective catalysts are generally constructed from precious metals. Here, the authors report a high-performing earth-abundant alternative system for this reaction based on a particular form of cobalt on siliceous zeolites.

Molecular electronics or spintronics relies on manipulating the electronic transport through microscopic molecule structures. Here the authors demonstrate the selective electron pathway in single-molecule device by magnetic field which enables a tunable anisotropic magnetoresistance up to 93%.

It is challenging to design anti-freezing electrolytes for extremely low-temperature aqueous batteries. This study proposes a general guideline for designing anti-freezing electrolytes by choosing H₂O–solute systems with low eutectic temperature and strong super-cooling ability, and demonstrates aqueous Na-ion batteries that can operate at the ultralow temperature of −85 °C.

Metabolic dysregulation in the development of clear cell renal cell carcinoma (ccRCC) remains to be understood. Here the authors identify that a carnitine synthesis enzyme BBOX1, which inhibits TBK1-mTORC1 signaling and glycolysis, is often lost in ccRCC.

Pt oxides are essential catalysts in many critical reactions, but are typically unstable and prone to evaporation above 700 K. A two-dimensional layered Pt oxide with exceptional thermal stability is introduced, capable of surviving at high temperatures.

The generation of cracks in polycrystalline Ni-rich layered lithium transition metal oxides presents numerous challenges for their use in batteries. Here, authors propose a gradiently distributed pores structure within the oxide secondary particles, reducing internal strain accumulation.

Selective photo-oxidation of CH₄ to value-added C₁ oxygenates remains challenging. Here, the authors propose construct mono-copper sites within a framework platform to optimize O₂ activation, enabling highly selective conversion of CH₄ to HCHO.

Given the association of gut microbiota dysbiosis with hypertriglyceridemic pancreatitis (HTGP), authors assess the gut microbial diversity of patients with HTGP, and provide immunological insight utilising a murine model.

Core fucosylation of N-linked glycoproteins has been linked to physiological and pathological processes. Here, the authors develop a mass spectrometry-based method that utilizes Endo F3 followed by PNGase F treatment to quantify site-specific glycoprotein core fucosylation in protein mixtures.

Devices with a wide-temperature range persistent photoconductivity (PPC) and low power consumption is a challenge for optical synaptic devices in neuromorphic computing. Here, the authors develop a carbon nanotube/porphyrin heterojunction on a flexible array, achieving PPC between 77 K to 400 K.

Under conditions of Earth’s deep lower mantle, hydrogen ions diffuse freely through the FeOOH lattice framework and electrical conductivity increases rapidly, according to electrical conductivity experiments and first-principles simulations.

Six rhesus macaques injected with a cadmium-based quantum-dot formulation survived without any evidence of toxicity, but cadmium remained in certain organs after 90 days.

Functional revascularization is vital to the recovery of blood flow. Here, Sun et al. show that myofiber FNIP1 is a negative regulator of muscle functional angiogenesis and revascularization after ischemia by controlling macrophage recruitment.

A nucleic acid immunoassay implemented on a lateral flow strip accurately detects SARS-CoV-2 RNA in less than one hour via a fluorescence readout.

Solid polymer electrolytes are commonly used in lithium-metal batteries, but their capacity and energy density cannot be easily increased beyond a charging cut-off voltage of 4.5 V due to the presence of easily oxidized oxygen-bearing polar groups. Here, authors apply a polyfluorinated crosslinker to enhance the oxidation resistance to solve this issue

To suppress the polysulfide shuttling effect in Li-S batteries, here the authors report a carbon/sulfur composite cathode with a wrapping layer that overcomes the trade-off between limiting polysulfide diffusion and allowing electrolyte infiltration, and affords extraordinary cycling stability.

Super-concentrated water-in-salt electrolytes enable high-voltage aqueous batteries, but have considerable drawbacks such as high viscosity, low conductivity and slow kinetics. Now a concentration-dependent association between CO₂ and TFSI^– has been discovered and leveraged to decouple the interphasial responsibility of an aqueous electrolyte from its bulk properties, making high-voltage aqueous Li-ion batteries practical in dilute salt-in-water electrolytes.

A competitive-chemical-reaction-based growth mechanism by controlling the kinetic parameters can easily realize the growth of transition metal chalcogenides and transition metal phosphorous chalcogenides with different compositions and phases.

Phage-assisted continuous evolution of Cas9 variants with broad PAM compatibility and high DNA specificity that can be used for transcriptional activation, gene disruption and base editing.

Polysulfide/iodide redox flow batteries are promising due to low cost and high-solubility components, but are limited by energy efficiency and power density. Here the authors fabricate heterojunction electrocatalysts to achieve improved performance in a polysulfide/iodide redox flow battery.

Intensive efforts are underway towards developing battery-based grid-scale storage technologies. Here, the authors report an aqueous K-ion battery that offers many attractive advantages over various battery alternatives.

Unravelling the mechanism of the recognition of the highly pathogenic influenza A viruses by antibodies is important for understanding their protective function. Zuo et al. characterise the mechanism of recognition of the H5N1 influenza virus by human monoclonal antibodies isolated from convalescent individuals.

Altered dosage of developmental regulators such as transcription factors can result in disorders, such as FOXG1 syndrome. Here, the authors demonstrate the utility of SMASh technology for modulating protein dosage by modeling FOXG1 syndrome using human pluripotent stem cell-derived neurons and neural organoids.

clusterProfiler is a tool for characterizing and visualizing omics data. The example procedures show integration of metabolomics and metagenomics analyses, characterization of transcription factors and annotation of cells in single-cell studies.

In this Case Study, the authors describe a patient with systemic lupus erythematosus and diffuse alveolar hemorrhage whose condition did not respond to high-dose corticosteroid therapy. Disease remission was achieved following treatment with umbilical-cord-derived mesenchymal stem cell transplantation.

The record hot year of 2015 in Africa had devastating impacts. The likelihood of future annual temperature extremes over Africa exceeding those of 2015 are 91% and 100% in 1.5 °C and 2 °C worlds, respectively, stressing the benefits of limiting future anthropogenic warming.

SparseFLIM enhances fluorescence lifetime imaging by reconstructing high-fidelity images from sparse photon data, generalizing across various imaging modalities, addressing fundamental trade-offs in FLIM to enable faster and higher-quality imaging.

A cynomolgus monkey model deficient in SIRT6 protein exhibits severe retardation in prenatal development, in which neuronal differentiation is delayed by activation of the H19 long non-coding RNA.