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Study shows PTSD predisposition shares distinct genes and genomic regions with several cardiovascular conditions. Here the findings reveal neuronal, immune, and metabolic pathways, and repurposed drug targets that further the understanding of the comorbidity.

The CAPItello-291 phase 3 study reported that capivasertib (an AKT inhibitor) and fulvestrant (a selective estrogen receptor degrader) improved progression free survival in patients with HR-positive/HER2-negative advanced breast cancer. Here, the authors report the results of an extended Chinese cohort recruited as part of the original global CAPItello-291 study.

Nasal anti-CD3 therapy shows promise for treating traumatic brain injury by reducing neuroinflammation and aiding recovery in mice. It induces interleukin-10-producing regulatory T cells that enhance microglial phagocytic activity and reduce chronic inflammation, potentially aiding brain repair.

Somatic cloning of rhesus monkey has not been successful until now. Here, authors report epigenetic abnormalities in SCNT embryos and placentas and develop a trophoblast replacement method that enables them to successful clone of a healthy male rhesus monkey.

Here, the authors perform large trans-ancestry fine-mapping analyses identifying large numbers of association signals and putative target genes for colorectal cancer risk, advancing our understanding of the genetic and biological basis of this cancer.

FADD binds Casp-8 and then cFLIP to form the FADD-Casp8-cFLIP complex. The authors found that the DED complex could assemble in reverse order, where cFLIP oligomerizes to bind Casp-8. The resultant complex could bind FADD, generating the cFLIP-Casp-8-FADD complex by a different mechanism.

How Draper activates phagocytosis is not well understood. Here, the authors show that two Drosophila galectins, Hdg and Ctg, are secreted from hemocytes after dendrite injury and bridge phosphatidylserine and Draper to active phagocytosis.

Goodman et al. found that Tau is critical for ROS-induced lipid droplet formation in glia from flies and mammals. Too much or too little glial Tau disrupts lipid droplets, leaving the glia susceptible to neuronal ROS-induced damage and causing phenotypes in tau^−/− flies.

In mouse models of pulmonary metastasis, adjuvant epigenetic therapy targeting myeloid-derived suppressor cells disrupts the premetastatic microenvironment after resection of primary tumours and inhibits the dissemination of residual tumour cells.

A deep learning model provides high accuracy in detecting pancreatic lesions in multicenter data, outperforming radiology specialists.

Methods for the anti-Markovnikov-selective hydrochlorination of unsaturated C–C bonds are limited by the need for stoichiometric reagents, highly oxidizing photocatalysts and multiple synthetic steps. Now the combination of ligand-to-metal charge transfer and hydrogen atom transfer reactivity enables the anti-Markovnikov-selective hydro- and deuterochlorination of unsaturated hydrocarbons using iron photocatalysis.

The monitoring of vital physiological parameters exemplified by intracranial pressure is of paramount importance. Here, the authors propose an ultrasensitive multimodal biotelemetric system to monitor ICP, respiratory, and heart rate.

Here the authors structurally and mechanistically characterize the assembly of FADD, procaspase-8, and cFLIP through their death-effector domains (DEDs), providing insights into the regulation of apoptotic and necroptotic signalling.

This manuscript evaluates forecasts of laboratory-confirmed influenza hospital admissions, a new target for influenza forecasting in the United States. Across two influenza seasons, the FluSight ensemble is robust compared to submitted models.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Triboelectric nanogenerators have shown promising potential towards self-powered wearable electronics and devices. Here, authors introduce topological insulators to enrich the current triboelectric family of materials and sensing technologies.

Understanding how hydrogen embrittles steels and developing the solutions are crucial for enabling the hydrogen economy. Here, the authors report a materials design strategy that can increase the hydrogen trapping capacity by creating carbon vacancies in metal carbide precipitates via microalloying.

A germanium–silicon single-photon avalanche diode operated at room temperature shows a noise-equivalent power improvement over the previous Ge-based single-photon avalanche diodes by 2–3.5 orders of magnitude.

A universal interface connects soft, rigid and encapsulation modules together to form robust, stretchable devices in a plug-and-play manner by pressing without using pastes, which will simplify and accelerate development of on-skin and implantable devices.

Cutaneous T-cell lymphoma (CTCL) is a rare type of non-Hodgkin lymphoma that affects the skin. Here authors show that CDK9 degradation of retinoic acid receptor α is a vulnerability for CTCL and develop a degrader targeting CDK9 that synergizes with all-trans retinoic acid to reduce CTCL tumor growth.

Vaccination and immune-regulation strategies are crucial for the prevention and treatment of respiratory infectious diseases. This Review discusses the design and optimization of nanomedicines for vaccines and immunotherapeutics for respiratory infectious diseases.

Methanol and syngas are important fuels and chemicals, which are presently produced from fossil resources. Here, the authors report the conversion of biomass-derived polyols and sugars into methanol and syngas via UV light irradiation under room temperature.

The low photoluminescence quantum yield of near-infrared (NIR) emitters has limited their application in organic light-emitting diodes (OLEDs). Here, authors realize NIR OLEDs through interfacial energy transfer from platinum(II) complexes to a non-fullerene acceptor based on a sandwiched structure.

Alkene hydrofluoroalkylation offers a promising route to diverse fluoroalkylated compounds but current methods have limitations, such as needing expensive fluoroalkylating reagents. Now, leveraging iron photocatalysis and hydrogen-atom-transfer catalysis, a hydrofluoroalkylation method has been developed that utilizes feedstock chemicals such as trifluoroacetic acid as direct fluoroalkyl radical precursors, providing a redox-neutral, general protocol to introduce fluoroalkyl moieties.

The transport behavior of high-entropy alloys (HEAs) remains unclear. Here, the authors explore the fundamentals of low-wear and high-conductivity refractory HEAs, examining the cocktail effect in conductivity, and highlight its potential applications in enhancing atomic-scale image resolution.

Hydrogen can be used to reduce the concentration of reactive oxygen species (ROS), but its delivery to diseased tissues is challenging due to its low solubility. Here the authors develop a photosynthesis-inspired FRET nanocomplex to detect and scavenge local excess of ROS in the tissue using photocatalytic hydrogen production.

Regulatory T cells (Tregs) are known for suppressing inflammatory processes, but their full capacity for tissue regeneration is yet to be harnessed. Here, the authors demonstrate the efficiency of Tregs in facilitating tissue healing in mouse models of bone, muscle, and skin injury, with monocytes/macrophages and interleukin-10 playing a key mechanistic role in the process.

Multi-ancestry genome-wide analyses identify 95 loci associated with post-traumatic stress disorder and implicate candidate genes, pathways and neurobiological systems underlying its pathophysiology.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Recently, Rydberg excitons have been demonstrated in transition metal dichalcogenide moire superlattices. Here, using atomic-scale imaging, the authors observe Rydberg structure and moire periodicity of ground-state interlayer excitons in a monolayer YbCl₃ on highly oriented pyrolytic graphite.

A genome-wide association study suggests 41 previously unreported loci on top of the 23 known loci that influence the disease risk for lumbar disc herniations. Many of these loci harbour genes implicated in disc structure and inflammation, as well as genes related to the nervous system and nerve function.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

After myocardial infarction, excessive inflammation impairs heart repair, leading to reduced cardiac function. Here, the authors show that treatment with anti-inflammatory immune cells (regulatory T cells) improves cardiac repair by modulating the activity of a specific subset of macrophages in the heart.

A multi-ancestry genome-wide association study meta-analysis, combined with transcriptome- and methylome-wide association analyses, identifies risk loci associated with colorectal cancer. Credible effector genes and their target tissues are also highlighted, showing that over a third probably act outside the colonic mucosa.

Rhombohedral-stacked molybdenum disulfide with sliding ferroelectric behaviour can be used to create atomically thin ferroelectric transistors for computing-in-memory device applications.