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Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

International export accounted for up to ten percent of particulate matter pollution in China in 2017, according to combined atmospheric and economic model analysis.

The evolutionary trajectory of avian sex chromosomes may be more intricate than previously understood. In this study, sequencing and analysis of the neo-sex chromosomes and genome of the Crested Ibis suggests a multidirectional evolution of sex chromosomes in core waterbirds.

Nutrient resorption is crucial for evaluating plant nutrient status and ecosystem carbon dynamics, but direct measurements in permafrost ecosystems are very limited. Here, the authors explore large-scale pattern of plant nutrient resorption and its relationship with soil nutrient supply across Tibetan alpine permafrost region.

Zinc-ion electrochemical cells are limited by cycling stability and low electrode utilization. Here, authors present designs to enhance the cumulative capacity of zinc-ion supercapacitors by reducing zinc dendrites and increasing porous carbon activation, improving capacity and cycle life.

Ma et al. show that heterogeneous nuclear ribonucleoprotein U promotes the primed state in human pluripotent stem cells by interacting with nuclear matrix protein, Matrin-3, and regulating primed-specific genes.

Existing 3D Spatial Transcriptomics reconstruction approaches often overlook spatial information or experiment-induced distortions. Here, authors propose ST-GEARS to bridge the gap between in vivo cell locations and in vitro analysis, accurately recovering spatial profiles.

Base-induced elimination (E2) and bimolecular nucleophilic substitution (SN2) are of significant importance in physical organic chemistry. Here, the authors show that the competing factor of E2 as opposed to steric hindrance determines the low reactivity of SN2 in the F⁻ + (CH₃)₃CI reaction.

Feshbach resonances are transiently trapped states along a reaction coordinate, providing a probe to the reaction’s potential energy surface (PES) but difficult to analyze in polyatomic systems. Here the authors identify Feshbach resonances in a reacting 4-atom system by state-to-state quantum dynamics using a full-dimensional PES.

Transition metal carbides exhibit outstanding performance in the selective hydrogenation of acetylene, but carburizing Pd-based intermetallic compounds has been challenging. Here, the authors present a successful synthesis of Pd₃ZnC_x intermetallic carbide for selective hydrogenation of acetylene through a one-step co-infiltration of zinc and carbon using syngas.

m⁶A-SAC-seq uses chemical labeling to quantify m⁶A at single-base resolution in the mammalian transcriptome.

Non-enterotoxigenic Bacteroides fragilis (NTBF) is abundant in colorectal cancer (CRC) patients and in a high-fat diet (HFD)-induced CRC model. Here the authors show that bile salt hydrolase-expressing NTBF is enriched in CRC patients with overweight and promotes tumor growth in an HFD-induced CRC mouse model.

Non-alcoholic steatohepatitis has with few well-defined biomarkers or clinically effective treatments but is promoted by inflammation. Here, the authors find an active lipid [So(d18:1)] that is significantly changed in patients and promotes inflammation by directly inhibiting macrophage HIF-2α.

Lipid nanoparticles (LNPs) are the preeminent drug delivery vehicle for mRNA therapies, partially due to the ionizable lipid (IL) components that facilitate endosomal escape. Here, authors devise terminally branched ILs that enhance endosome escape, resulting in increased liver and T cell delivery.

There is a growing interest in the role of timing of physical activity (PA) in improving health. Here, using a large-scale cohort study, the authors show that moderate-to-vigorous PA at the optimal time of day robustly predicts lower mortality risk and may maximize the beneficial effect of PA.

Urinary proteomics offers sensitive, non-invasive biomarkers, but cross-platform LC-MS data comparability requires investigation. Here, the authors evaluate 20 LC-MS platforms, developing MSCohort, a QC system with 81 metrics, and a unified SOP, paving the way for precision medicine research.

Cepharanthine is a secondary metabolite isolated from Stephania with a variety of medicinal properties. Here, the authors assembled three Stephania genomes, propose cepharanthine biosynthetic pathway, and assess the antiviral potential of cepharanthine-related metabolites.

Nicotine accumulates in the intestine during tobacco smoking and accelerates the progression of non-alcoholic fatty liver disease to non-alcoholic steatohepatitis (NASH), but it can be degraded effectively by the human symbiont Bacteroides xylanisolvens.

Toxic amyloid-beta plaque and harmful inflammation are two leading hallmarks of Alzheimer’s disease (AD), and precise AD therapy is elusive due to the lack of dual-targeting therapy function, limited blood-brain barrier penetration, and low imaging sensitivity. Here, the authors address these issues by designing a near-infrared-II aggregation-induced emission nanotheranostic for precise AD therapy.

Here, Xin Pan and colleagues found that activation of thyroid hormone receptor-β is necessary for alveolar epithelial cell differentiation during lung repair and regeneration, and confirmed a specific agonist and molecular targets for fibrosis therapy.

Approaches to treat inflammatory bowel disease with probiotics or artificial enzymes have advantages and limitations. Here we combine the advantages to overcome the individual limitations by modifying probiotics with artificial enzymes and demonstrate application in treating inflammatory bowel disease.

Plant viruses adopt diverse strategies to inhibit host antiviral defense. Here the authors show that multiple different effectors from various rice viruses interfere with host gibberellin signaling by targeting the DELLA protein SLR1.

This study presents an advanced ChIP-seq method, provides a valuable epigenomics resource for 14 economically important plant organs and reveals histone modification landscape dynamics and functions during rapeseed seed dormancy and germination.

TAAR1 has a rigid consensus binding motif that binds to endogenous trace amine stimuli as well as two extended binding pockets that accommodate diverse chemotypes.

Grain of indica rice accumulates more toxic cadmium (Cd) than japonica, but the underlying genetic basis is unclear. Here, the authors show that natural variation of OsCd1 contributes to divergence in grain Cd accumulation and transferring japonica allele to indica rice leads to reduced Cd accumulation.

The Montreal Protocol globally phased out ozone-layer depleting CCl₄ by 2010. However, atmospheric measurements show eastern China emitted ~7.6 gigagrams/year in 2021–2022. Further, industrial sources of ongoing CCL₄ emissions are identified.

Reward circuit dysfunction is a mechanism for key emotional disorders that commonly arise after early life stresses (ELA). Here, the authors discover a projection from amygdala to nucleus accumbens that underlies ELA-induced reward deficits in mice.

Sulfur dioxide emissions due to consumption by developed and developing countries differ in magnitude but produce comparable climate impacts due to the regional distribution of emissions, according to simulations using an Earth system model.

The realization of intrinsically stretchable organic photovoltaics with excellent mechanical robustness remains challenging. Here, the authors redistribute the strain in the active layer to PEDOT:PSS electrodes with simultaneously enhanced stretchability and interfacial adhesion in the device.

Detect-seq, built upon chemical labeling and enrichment of intermediate deoxyuridine, offers an approach to profile different types of off-target mutation induced by cytosine base editors including unexpected edits outside of protospacer and on the target strand.

Metformin decreases the levels of Bacteroides fragilis while increasing the bile acid GUDCA to antagonize intestinal FXR and improves the metabolic health of humans and mice.

Food safety is jeopardized by the global trade in contaminated foods. Huang et al. demonstrate how consumer exposure to the toxic chemical polychlorinated biphenyl-153 (PCB-153) can be modelled and identify regions with high consumer PCB-153 exposure resulting from imported fish consumption.

Analysis of the bracteatus pineapple genome provides insight into fiber production, color formation, sugar accumulation and fruit maturation. Resequencing of 89 Ananas genomes supports the coexistence of sexual recombination and a ‘one-step operation’ during domestication.