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Shallow NV centers in diamond are promising quantum sensors but suffer from reduced coherence times due to surface spin impurities. Here the authors improve coherence times to over 1 ms through interface engineering by oxygen-terminating the diamond surface and patching it with graphene.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Nie et al. show that myocardial CCDC25 detects doxorubicin-induced neutrophil extracellular trap DNA and activates reactive oxygen species production and autophagy, leading to cardiotoxicity. Targeting CCDC25 exerts a cardioprotective effect without impacting the antitumor activity of doxorubicin in lymphoma and breast cancer models.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Toxic methylmercury in soil can accumulate in rice grains. Here, the authors use DNA stable-isotope probing and metagenomics to identify soil microbes and pathways potentially involved in methylmercury degradation.

Acrolein, a byproduct of polyamine metabolism and chemotherapeutic agents, is also found in cigarette smoke. Here the authors report that acrolein mediates spermine-induced ferroptosis, while in ferroptosis-resistant cancer cells, acrolein suppresses necroptosis by inhibiting the oligomerization of MLKL, contributing to chemotherapy resistance.

PAPD5 is responsible for adenylation of microRNAs. Here, the authors show that elevated level of PAPD5 enhances the adenylation and reduced expression of miR-7-5p. As a result, expression of TAB2, a target of miR-7-5p, is induced triggering neuronal apoptosis in Huntington’s disease.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

The molecular mechanisms underlying the function of different cellular states in glioblastoma stem cells (GSCs) remain poorly understood. Here, the authors perform integrated single cell and bulk analysis of GSCs and identify potential therapeutic targets.

Cerebrospinal fluid circulating tumor DNA profiling had prognostic value in a cohort of 584 patients with lung cancer and central nervous system metastases, and could be used to inform personalized therapies.

This study presents an oral CRISPR–Cas9 delivery system that precisely disrupts the TRAP1 gene in colorectal cancer, enhancing chemo-immunotherapy with robust antitumour effects.

Oxidative stress contributes significantly to postmenopausal osteoporosis by impairing osteoblast function, but its precise mechanisms remain unclear. Here, the authors show that estrogen deficiency reduces GPX4 expression, leading to phospholipid peroxidation that impairs osteoblastogenesis, while GPX4 activators including 6- and 8-Gingerols can mitigate these effects.

Scavenger receptor class A member 3 (SR-A3) is implicated in metabolic diseases, but its relationship with MAFLD remains unclear. Here, the authors show that SR-A3 is an important modulator of hepatic energy metabolism and is a potential therapeutic target against MAFLD.

Cobalt-free Mn-based lithium metal batteries suffer from serious Mn dissolution and lithium dendrite problems. Here, authors propose ferrocene hexafluorophosphate as an electrolyte additive to achieve dynamic doping of positive electrode and interphase stabilization of electrodes.

This work focuses on the characterization of CLE peptide gene, revealing how the TaCLE24b-TaCLV1 signaling cascade together with TaSG-D1 modulate lateral root development and drought stress tolerance in wheat.

The authors encode qutrit contextual-Hamiltonian ground states into permutation-symmetric qubits with symmetry-preserving gates and use parameterized quantum circuits to variationally simulate their purified 3-site reduced states. They find that stronger contextuality reduces simulation cost, although all contextual states cost more than non-contextual ones.

Here, the authors develop an alkali-assisted chemical vapor deposition method to enhance the seeding process for WSe₂, and demonstrate the growth of 2-inch and centimeter-scale monolayer and bilayer WSe₂ films.

Here, the authors analyzed 2923 plasma proteins through prospective cohort and genetic analyses, identifying IL12B, CD6, MXRA8, CXCL9, IFNG, CCN3, RSPO3, and IL18 as prioritized potential therapeutic targets for inflammatory bowel disease, offering insights into its mechanisms and treatment.

The apelin receptor (APJR) is a drug target for cardiovascular and metabolic health. Here, authors reveal how ligand binding, receptor dimerization, and G protein coupling cooperate to regulate APJR signaling pathway, providing insight for drug discovery.

The genomic epidemiology of Acinetobacter baumannii, which is rising in virulence and multidrug resistance, was explored. This study examined bloodstream infection isolates from Chinese patients in 2011–2021, revealing increased genetic diversity and dominance of highly virulent ST208.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Lysosomes are the major degradative compartments within cells, but little is known about cellular mechanisms that control lysosome quality. Here Hung et al.show that lysosomes damaged by light-induced activation of a photosensitizer are selectively ubiquitinated and subsequently eliminated by autophagy.

Achieving high-performance conjugated polymers with intrinsic flexibility and printable capacity is a great challenge. Here, the authors report asymmetric substituted polymers with strong inter aggregate capillary interaction for deep-blue flexible printed polymer light-emitting diodes.

Searching non-charge-based devices is crucial for sustainable information processing. Here, the authors make a nonvolatile magnon field effect transistor at room temperature, enabling efficient magnon transport control via the gate voltage pulses.

Fe₃₄Co₂₉Ni₂₉Al₃Ta₃Si₂ high entropy alloy fibers with low coercivity and large plasticity are prepared. The fibers have a tensile strength of 674 MPa at 23% elongation, a coercivity of 8.1 Oe and a high Curie temperature of 770 K.

Field-free switching of the perpendicular yttrium iron garnet magnetization with considerable efficiency is desired for device performance. Here, the authors demonstrate such an accomplishment with a collinear spin current in Py.

Synthetically replicating transmembrane protein signal transduction is a gaol of synthetic biology. Here, the authors show how the dimerization of synthetic transmembrane DNA receptors can be used to engineer sensing and actuation cascades in response to external molecular signals.

Difficulties in propagating HRV-C have hindered our understanding of this common respiratory pathogen. Here, authors developed an organoid-based system to reproducibly propagate HRV-C and characterized HRV-C infection in physiologically active respiratory organoids.

Dissipative self-assembly, which requires a continuous supply of fuel to maintain the assembled states far from equilibrium, is the foundation of biological systems but it remains a challenge to introduce light as fuel into artificial dissipative self-assemblies. Here, the authors report an artificial dissipative self-assembly system that is constructed from light-induced amphiphiles.

Sakuranetin is an important phytoalexin. The authors find that sakuranetin in rice attenuates endocytosis of effectors from the fungus Magnaporthe oryzae and enhances resistance against rice blast.

Revealing structural isomerism in nanoparticles remains a largely unresolved task. Here, the authors use several techniques, including single-crystal X-ray crystallography, to characterize two structural isomers of Au₃₈, and report their different optical and catalytic properties and differences in stability.

While microparticle shape can have significant influence on their properties, simple ways to control shape are difficult to achieve. Here, the authors report a method giving a high degree of control over the shape of such structures by generating gradients of oxygen concentration during photopolymerization.

The realization of intrinsically stretchable fully π-conjugated polymer film is challenging due to their inherent brittle nature. Here, authors apply semiconductor fluid molecular plasticizers to improve stretchable deformability, achieving high performance flexible polymer light-emitting diodes.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

With the help of an orbital spinning technique, substrate-free open networks of imperceptible fibres can be created on a range of biological surfaces, providing on-skin sensors that can record electrocardiogram signals, skin-gated organic electrochemical transistors, and augmented touch and plant interfaces.

Endothelin-1 activation after SARS-CoV-2 infection leads to vascular permeability, chondrocyte senescence, osteoclast activation and cyst formation in affected joints of hamsters, which can be alleviated using macitentan. Joint injury was also seen in two patients after COVID-19 infection.

Through rational engineering of A3A deaminase, Yang and colleagues have designed CBEs termed haA3A-CBEs, which feature a condensed editing window and minimal off-target effects that are independent of defined sequence contexts and methylation status.

Ligand-protected metal nanoclusters provide an ideal platform for investigating the balance of stability and activity in photoredox catalysis. Here, the authors apply a photochemical reduction–oxidation cascade method to synthesize an Au₈Cu₆ nanocluster with a robust structure and active surface.

Atherosclerosis is associated with the dysregulation of lipid metabolism in vascular endothelial cells. Here, the authors show that the accumulation of lipid droplets in vascular endothelial cells disrupts endothelial ciliation and contributes to atherosclerosis by reducing cytosolic palmitic acid.

Shen et al. identify a noncanonical role for the inflammasome protein NLR family CARD ___domain-containing protein 4 (NLRC4) to attenuate tumor development. NLRC4 forms a scaffold to assemble the ataxia telangiectasia and Rad3-related DNA repair complex and the repair kinase checkpoint kinase-1 to promote repair of DNA breaks.

C-C bond scission of unstrained cycloketones with high regioselectivity is a challenging synthetic task. Here, the authors show a facile C-C cleavage of cyclohexanones and cyclopentanones with unusual selectivity under mild conditions with the aid of an in situ formed side-chain aryl radical.