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Showing 1–50 of 57 results

Advanced filters: Author: Masashi Nishimura Clear advanced filters

Single-cell analysis reveals immune cell abnormalities underlying the clinical heterogeneity of patients with systemic sclerosis

Clinical manifestations in patients with systemic sclerosis (SSc) are highly heterogeneous, and identifying the root causes of clinical symptoms is challenging. Here, by performing single-cell profiling of peripheral blood from SSc patients, the authors identify distinct immune abnormalities associated with acute organ complications, including interstitial lung disease and scleroderma renal crisis.

Hiroshi Shimagami
Kei Nishimura
Masayuki Nishide
ResearchOpen Access17 Jun 2025
Nature Communications

Volume: 16, P: 1-18
Neutrophil single-cell analysis identifies a type II interferon-related subset for predicting relapse of autoimmune small vessel vasculitis

Neutrophils are early mediators for inflammation, but their functions in autoimmunity is still unclear. By using single cell analyses to compare patients with microscopic polyangiitis (MPA) and controls, here the authors find increased IFN-II-related neutrophils induced by IFN-γ and TNF signaling as a relapse risk marker for small vessel vasculitis.

Masayuki Nishide
Kei Nishimura
Atsushi Kumanogoh
ResearchOpen Access24 Apr 2025
Nature Communications

Volume: 16, P: 1-15
DNA typing of HLA in the patients with moyamoya disease

Takuya K. Inoue
Kiyonobu Ikezaki
Masashi Fukui
Research01 Dec 1997
Japanese Journal of Human Genetics

Volume: 42, P: 507-515
Coulombic self-ordering upon charging a large-capacity layered cathode material for rechargeable batteries

Here the authors report the evolution of stacking faults in Na₂RuO₃ showing that there is progressive cation ordering upon charging and notably the stacking faults can disappear. This behavior is driven by cooperative Coulombic interactions and can contribute to stabilizing the phase transformations.

Benoit Mortemard de Boisse
Marine Reynaud
Atsuo Yamada
ResearchOpen Access16 May 2019
Nature Communications

Volume: 10, P: 1-7
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

A new generation of broad and potent anti-HIV-1 monoclonal antibodies has recently been isolated; co-administration of two such antibodies is shown here to result in rapid and potent suppression of plasma viraemia in five chronically SHIV-infected macaques that lasts for several weeks.

Masashi Shingai
Yoshiaki Nishimura
Malcolm A. Martin
Research30 Oct 2013
Nature

Volume: 503, P: 277-280
Chitinase-Catalyzed Copolymerization to a Chitin Derivative Having Glucosamine Unit in Controlled Proportion

Akira Makino
Masashi Ohmae
Shiro Kobayashi
Reviews19 Oct 2006
Polymer Journal

Volume: 38, P: 1182-1188
Correction: Corrigendum: The landscape of somatic mutations in Down syndrome–related myeloid disorders

Kenichi Yoshida
Tsutomu Toki
Seishi Ogawa
Amendments and Corrections25 Nov 2013
Nature Genetics

Volume: 45, P: 1516
Single-cell multi-omics analysis identifies two distinct phenotypes of newly-onset microscopic polyangiitis

Autoimmune vasculitis can be heterogeneous in terms of immune cell involvement. Here the authors use a single cell transcriptomics approach to characterise a group of microscopic polyangiitis patients that could be split into two groups typified by monocyte or Interferon associated gene expression.

Masayuki Nishide
Kei Nishimura
Atsushi Kumanogoh
ResearchOpen Access11 Oct 2023
Nature Communications

Volume: 14, P: 1-14
Usefulness of gastric aspirates for diagnosing nontuberculous mycobacteriosis

Masafumi Shimoda
Kozo Morimoto
Ken Ohta
ResearchOpen Access15 May 2023
Scientific Reports

Volume: 13, P: 1-5
Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7

The Bin/Amphiphysin/Rvs167 (BAR) ___domain superfamily, which includes FCH-BAR (F-BAR) ___domain proteins are membrane-sculpting proteins. Here the authors combine a range of techniques and show that the F-BAR ___domain of growth-arrest specific protein 7 (GAS7) forms two-dimensional sheets on flat membranes and that these oligomeric assemblies of GAS7 are required for the formation of phagocytic cups in macrophages.

Kyoko Hanawa-Suetsugu
Yuzuru Itoh
Shiro Suetsugu
ResearchOpen Access18 Oct 2019
Nature Communications

Volume: 10, P: 1-13
Male–female disparity in clinical features and significance of mild vertebral fractures in community-dwelling residents aged 50 and over

Shota Ikegami
Masashi Uehara
Jun Takahashi
ResearchOpen Access07 Mar 2024
Scientific Reports

Volume: 14, P: 1-8
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Deficiency of TMEM53 causes a previously unknown sclerosing bone disorder by dysregulation of BMP-SMAD signaling

Sclerosing bone disorder (SBD) includes a broad spectrum of monogenic diseases characterised by increased bone density. Here, the authors describe a previously unknown SBD in four families caused by mutations in TMEM53 and demonstrate the role this protein plays in BMP signalling during bone formation.

Long Guo
Aritoshi Iida
Shiro Ikegawa
ResearchOpen Access06 Apr 2021
Nature Communications

Volume: 12, P: 1-13
Synthesis of 2-Hydroxyethyl Methacrylate–Dimethylsiloxane Block Copolymers and Their Ability to Suppress Blood Platelet Aggregation

Masashi Shimada
Masaru Miyahara
Yasuhisa Sakurai
Research01 Sept 1983
Polymer Journal

Volume: 15, P: 649-656
Synthesis and Properties of Helical Poly(macromonomer) Consisting of Polyacetylene Main Chain and Poly(methyl methacrylate) Side Chains

Masashi Shiotsuki
Wei Zhang
Toshio Masuda
Research16 May 2007
Polymer Journal

Volume: 39, P: 690-695
Novel mutations in the COL2A1 gene in Japanese patients with Stickler syndrome

Hiroyuki Kondo
Itsuka Matsushita
Shunji Kusaka
ResearchOpen Access07 Jul 2016
Human Genome Variation

Volume: 3, P: 1-4
Intermediate honeycomb ordering to trigger oxygen redox chemistry in layered battery electrode

Sodium-excess metal oxides Na₂MO₃ are appealing cathode materials for sodium-ion batteries. Here, the authors demonstrate that honeycomb-type cation ordering in Na₂RuO₃ triggers the oxygen redox reaction via frontier orbital reorganization, increasing the capacity by 1/3 compared with disordered Na₂RuO₃.

Benoit Mortemard de Boisse
Guandong Liu
Atsuo Yamada
ResearchOpen Access18 Apr 2016
Nature Communications

Volume: 7, P: 1-9
Early antibody therapy can induce long-lasting immunity to SHIV

Early administration of broadly neutralizing antibodies in a macaque SHIV infection model is associated with very low levels of persistent viraemia, which leads to the establishment of T-cell immunity and resultant long-term infection control.

Yoshiaki Nishimura
Rajeev Gautam
Malcolm A. Martin
Research13 Mar 2017
Nature

Volume: 543, P: 559-563
Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma

Kenro Oshima
Shigeyuki Kakizawa
Shigetou Namba
Research07 Dec 2003
Nature Genetics

Volume: 36, P: 27-29
Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease

IRF5 is a potential target for therapy in systemic lupus erythematosus (SLE). Here the authors show using mouse SLE-like models that genetic or chemical inhibition of IRF5 after SLE onset could be more effective than, or an add on for, currently utilised type I interferon inhibition.

Tatsuma Ban
Masako Kikuchi
Tomohiko Tamura
ResearchOpen Access19 Jul 2021
Nature Communications

Volume: 12, P: 1-14
Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

Masashi Mizokami and colleagues report a genome-wide association study to hepatitis C treatment response in two Japanese cohorts. They report common variants at IL28B associated with sustained as well as null virologic response following pegylated interferon-alpha and ribavirin combined therapy.

Yasuhito Tanaka
Nao Nishida
Masashi Mizokami
Research13 Sept 2009
Nature Genetics

Volume: 41, P: 1105-1109
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes

De novo mutations significantly contribute to autism spectrum disorders (ASD). Here, the authors demonstrate that ASD-associated de novo mutations in the POGZ gene, one of a high-confidence ASD gene, lead to ASD-related impaired neuronal development and disrupted mature cortical network function.

Kensuke Matsumura
Kaoru Seiriki
Takanobu Nakazawa
ResearchOpen Access26 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Determination of Stereochemical Compositions of Oligo- and Poly(α-methylstyrene)s by ¹H and ¹³C NMR

Masashi Osa
Masakazu Sumida
Koichi Hatada
Research01 Apr 2000
Polymer Journal

Volume: 32, P: 361-369
Physical performance reflects cognitive function, fall risk, and quality of life in community-dwelling older people

Shota Ikegami
Jun Takahashi
Hiroyuki Kato
ResearchOpen Access22 Aug 2019
Scientific Reports

Volume: 9, P: 1-7
The landscape of somatic mutations in Down syndrome–related myeloid disorders

Seishi Ogawa and colleagues report the landscape of somatic mutations in Down syndrome–related myeloid disorders. They identify recurrent mutations in multiple cohesin components, CTCF and epigenetic regulators in Down syndrome–related acute megakaryoblastic leukemia.

Kenichi Yoshida
Tsutomu Toki
Seishi Ogawa
Research22 Sept 2013
Nature Genetics

Volume: 45, P: 1293-1299
Analysis of immunoglobulin transcripts and hypermutation following SHIV_AD8 infection and protein-plus-adjuvant immunization

HIV vaccine development will be facilitated by having animal models that are predictive for translation to humans. Here, the authors use two nonhuman primate models to compare the effects of natural infection and different adjuvants on antigen persistence, diversity and humoral immunity.

Joseph R. Francica
Zizhang Sheng
Robert A. Seder
ResearchOpen Access10 Apr 2015
Nature Communications

Volume: 6, P: 1-14
Helical Poly(N-propargylamide)s Derived from Lactic Acid: Effect of O-Acyl Groups on the Secondary Structures

Fumio Sanda
Toru Fujii
Toshio Masuda
Research02 Jul 2008
Polymer Journal

Volume: 40, P: 768-774
Effectiveness of cancer vaccine therapy using cells transduced with the interleukin-12 gene combined with systemic interleukin-18 administration

Isao Hara
Hiroshi Nagai
Sadao Kamidono
Research18 May 2000
Cancer Gene Therapy

Volume: 7, P: 83-90
Hemodynamic Influences of Losartan on the Brain in Hypertensive Patients

Naohiko Oku
Kazuo Kitagawa
Jun Hatazawa
Research01 Jan 2005
Hypertension Research

Volume: 28, P: 43-49
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Geriatric nutritional risk index and newly developed scoring system as prognosis prediction for unresectable hepatocellular carcinoma patients treated with lenvatinib

Hideko Ohama
Atsushi Hiraoka
Takashi Kumada
ResearchOpen Access02 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Identification and functional characterization of the extremely long allele of the serotonin transporter-linked polymorphic region

Tempei Ikegame
Yosuke Hidaka
Kazuya Iwamoto
ResearchOpen Access11 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-7
Chymase Inhibition Prevents Cardiac Fibrosis and Dysfunction after Myocardial Infarction in Rats

Hideo Kanemitsu
Shinji Takai
Masashi Komeda
Research01 Jan 2006
Hypertension Research

Volume: 29, P: 57-64
Stomagen positively regulates stomatal density in Arabidopsis

Stomata are specialized structures in the epidermal layer of leaves that regulate the exchange of gases between the plant and the atmosphere. One or more positive intercellular signalling factors are assumed to be involved in stomatal development, but their identities remain elusive. A novel secretory protein — named stomagen — is now shown to be just such a factor; it is conserved among vascular plants and positively regulates stomatal density.

Shigeo S. Sugano
Tomoo Shimada
Ikuko Hara-Nishimura
Research09 Dec 2009
Nature

Volume: 463, P: 241-244
Substitute parameters of exercise-induced pulmonary hypertension and usefulness of low workload exercise stress echocardiography in mitral regurgitation

Masashi Amano
Shoko Nakagawa
Chisato Izumi
ResearchOpen Access25 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
Evaluation of whole genome sequencing utility in identifying driver alterations in cancer genome

Takeshi Nagashima
Ken Yamaguchi
Yasuto Akiyama
ResearchOpen Access12 Oct 2024
Scientific Reports

Volume: 14, P: 1-10
Immunogenicity and protective efficacy of a co-formulated two-in-one inactivated whole virus particle COVID-19/influenza vaccine

Chimuka Handabile
Marumi Ohno
Hiroshi Kida
ResearchOpen Access20 Feb 2024
Scientific Reports

Volume: 14, P: 1-14
Precursor-directed in situ synthesis of Saccharothriolides G and H by the Actinomycete Saccharothrix sp. A1506

Shan Lu
Shinichi Nishimura
Hideaki Kakeya
Research21 Dec 2016
The Journal of Antibiotics

Volume: 70, P: 718-720
Author Correction: Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism

Kenji Nishimura
Taichi Murakami
Toshio Doi
Amendments and CorrectionsOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1
SETBP1 is dispensable for normal and malignant hematopoiesis

Atsushi Tanaka
Koutarou Nishimura
Daichi Inoue
Research18 Jul 2023
Leukemia

Volume: 37, P: 1802-1811
Distinctive features of single nucleotide alterations in induced pluripotent stem cells with different types of DNA repair deficiency disorders

Kohji Okamura
Hironari Sakaguchi
Akihiro Umezawa
ResearchOpen Access20 May 2016
Scientific Reports

Volume: 6, P: 1-10
Detection of cognitive decline by spinal posture assessment in health exams of the general older population

Hikaru Nishimura
Shota Ikegami
Hiroyuki Kato
ResearchOpen Access19 May 2022
Scientific Reports

Volume: 12, P: 1-8
Artificially-reconstructed brain images with stroke lesions from non-imaging data: modeling in categorized patients based on lesion occurrence and sparsity

Stephanie Sutoko
Hirokazu Atsumori
Toshio Tsuji
ResearchOpen Access16 Jun 2022
Scientific Reports

Volume: 12, P: 1-14
Optimal glycan density for interactions between Siglec-8 and sialyl sulfo oligosaccharides

The density-dependent changes of avidities between Siglec-8 and the glycan ligand of the α(2 → 6)-sialyl-6-sulfo-N-acetyllactosamine derivative (1) were investigated for the first time. The SAM surfaces with different glycan densities were constructed by changing the ratio of 1 and 3,3′-dithiodipropionic acid (DTPA) on the gold electrode of the quartz crystal microbalance (QCM). Next, we measured the apparent K_D values of 1 with Siglec-8 on the SAM surfaces by the QCM to investigate the effect of the glycan density on the avidity of the Siglec-8 interaction. The results obtained in this study suggest that Siglec-8 has an optimal glycan density (~9.2 × 10² molecules μm⁻²) for preferred interactions.

Risa Naka
Simon Sau Yin Law
Masashi Ohmae
ResearchOpen Access30 Aug 2023
Polymer Journal

Volume: 55, P: 1379-1386
Anemia in Patients with Severe Aortic Stenosis

Kazuya Nagao
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access13 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
Asymptomatic versus Symptomatic Patients with Severe Aortic Stenosis

Norio Kanamori
Tomohiko Taniguchi
Mitsuru Kitano
ResearchOpen Access04 Jul 2018
Scientific Reports

Volume: 8, P: 1-10
Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility

Yoshihiro Nawa
Hiroki Kimura
Norio Ozaki
ResearchOpen Access10 Nov 2020
Human Genome Variation

Volume: 7, P: 1-9
Identification of epigenetic memory candidates associated with gestational age at birth through analysis of methylome and transcriptional data

Kohei Kashima
Tomoko Kawai
Naoto Takahashi
ResearchOpen Access09 Feb 2021
Scientific Reports

Volume: 11, P: 1-16
The impact of ossification spread on cervical spine function in patients with ossification of the posterior longitudinal ligament

Keiichi Katsumi
Takashi Hirai
Yoshiharu Kawaguchi
ResearchOpen Access12 Jul 2021
Scientific Reports

Volume: 11, P: 1-9
Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism

Kenji Nishimura
Taichi Murakami
Toshio Doi
ResearchOpen Access16 Oct 2019
Scientific Reports

Volume: 9, P: 1-11

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