The V3 crown region of HIV-1 gp120 is involved in binding to co-receptors CCR5 and CXCR4, and show high sequence variability. Structural work with cross-clade neutralizing antibodies in complex with V3 peptides now reveals conserved structural elements in this variable region, which are minimally affected by sequence variation.
- Xunqing Jiang
- Valicia Burke
- Xiang-Peng Kong
