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The uneven surfaces of copper indium gallium selenide (CIGS) solar cells pose challenges for depositing the upper layers in flexible perovskite/CIGS tandem solar cells. Ying et al. tackle this issue using an antisolvent and seeding strategy, resulting in a certified efficiency of 23.8%.

Combination radiotherapy (RT) + αPD-L1 enhances tumor control via a tumor-draining lymph node (TdLN)-derived CD8+ PD-1+ TCF-1+ T cells. RT + αPD-L1 induces a novel LY6A+ subset in the TdLN that migrates to the tumor and differentiates into effectors.

Pairing center (PC) on each chromosome are crucial for homolog pairing and initiating synapsis in Caenorhabditis elegans. Here the authors investigate how the meiosis-specific proteins: ZIM/HIM-8 family recognize their cognate PC DNA motifs.

Multiomics joint analyses based on a structural variant (SV) map from 16 genome assemblies and 2,105 resequenced accession genomes shed light on the regulatory effect of SVs on gene expression and trait variation in Brassica napus.

Aneuploidy is associated with cancer metastasis, but the causal relationship between them is unclear. Here the authors show that aneuploid murine embryonic stem cells lead to teratomas that can spread to multiple organs without requiring additional driver gene mutations and identify unique cell populations with high stemness in aneuploid teratomas.

The combination of anti-PD-1 treatment with cisplatin and 5-fluorouracil in patients with previously untreated, PD-L1-positive esophageal squamous cell carcinoma improved progression-free survival and overall survival.

Perovskite/silicon tandem solar cells have attracted great attention for their efficiency and industry-compatible fabrication. Here, authors report a p-type tunnel oxide passivated contact structure with improved implied open-circuit voltage, achieving efficiency over 28% in 1 cm² n-i-p tandem cells.

Histamine mediates allergic reactions, inflammation, wakefulness, gastric acid secretion and neurotransmission, among others. Here, the authors determine 9 cryo-EM structures of the 4 histamine receptors in complexes with four different G protein subtypes, with endogenous or synthetic agonists bound, revealing their distinct features.

It remains unclear why a heightened proinflammatory cytokine response is observed during coronavirus infection. Here, Liu et al show that the envelope protein of severe coronaviruses triggers hyperinflammation by activating TMED10-mediated release of inflammatory factors.

Cassava is a major source of food in tropical and subtropical regions. Here the authors sequence the genomes of wild and domesticated cassava varieties and identify genes that have been selected for and against during the evolution and domestication of this economically important crop.

Whole-genome resequencing of 418 diverse rapeseed accessions and genome-wide association analyses for 56 agronomic traits provide insights into the genetic architecture and artificial selection or adaptation during modern rapeseed breeding.

The cryo-electron microscopy structure of the GPR101–Gs complex reveals the mechanism for its constitutive activity and facilitates the screening and identification of GPR101 ligands with rejuvenating potential.

The sphingosine-1-phosphate receptor 1 mediates the inhibitory effect of eicosapentaenoic acid on endothelial activation and atherogenesis, furthering our understanding of the cardioprotective role of omega-3 polyunsaturated fatty acids.

Structure of PSII-CAC from cryptophyte Rhodomonas salina reveals a distinct organization of CACs and the presence of CAL-II, which may play a critical role in stabilizing the dimeric PSII-CAC complex under stress conditions.

This study presents a comprehensive pipeline to profile transmembrane receptors involved in macrophage-driven inflammation in pancreatic islets during the onset of diabetes. The authors identify GPR132 as a mediator of macrophage-driven inflammation and find compounds that reduce inflammation and improve glycaemic control.

Here, the authors present structural and mechanistic characterisation of the UDP-dependent glycosyltransferase SgUGT94-289-3, which generates two mogrosides of interest as natural sweeteners. Structure-based engineering yielded variants with improved specificity and activity.

Zhou et. al. report the interim results of the randomized phase III GEMSTONE-302 trial, showing the overall survival benefits of first-line treatment with the PD-L1 inhibitor sugemalimab versus placebo in combination with chemotherapy, in patients with NSCLC.

Cryo-electron microscopy structures of mouse trace amine-associated receptor 9 reveals structural motifs involved in odorant ligand recognition, including a unique disulfide bond linking the N terminus to extracellular loop 2.

In Chlamydomonas reinhardtii, multiple units of light-harvesting complex I bind to the photosystem-I core, forming larger antennae than in plants. The structure, solved by cryo-electron microscopy, reveals details of antenna organization and functioning.

Implementation of deep reinforcement learning-based calibration algorithm in multi-wavelength optical information processing systems based on dispersion compensating fiber, microring resonators, and Mach-Zehnder interferometers.

Cyanobacterial photosystem I supercomplexes bind to iron-stress-induced proteins IsiA and flavodoxin under iron-deficiency conditions. They form a network that is highly efficient at light harvesting and retains normal electron transport efficiency.

TAAR1 has a rigid consensus binding motif that binds to endogenous trace amine stimuli as well as two extended binding pockets that accommodate diverse chemotypes.

Genetic, biochemical and high-resolution structural studies of chloroplast protein SOQ1 reveal the existence of a C-terminal lumenal ___domain with potential redox function and its essential role for suppressing photoprotection in plants.

Acyl-acyl carrier protein reductase (AAR) and aldehyde deformylating oxygenase (ADO) are the two enzymes in a cyanobacterial alkane biosynthesis pathway that is of interest for biofuel production. Here the authors provide insights into the catalytic mechanisms of AAR and the coupling between the two enzymes by determining the crystal structures of AAR alone and three AAR–ADO complexes with various bound ligands.

PsbS is a transmembrane photosystem II protein essential for photoprotection in plants. Crystal structures show that PsbS is not a canonical pigment-binding protein and provide insights into its pH-dependent activation mechanism.

The high-resolution structure of an Lhcb9-dependent PSI complex from Physcomitrium patens reveals the assembly details of this complex and the underlying mechanism by which P. patens switches between different types of PSI complex.

NAD(P)H dehydrogenase-like complex NDH-1L couples the electron transport from ferredoxin (Fd) to plastoquinone (PQ) and proton pumping from cytoplasm to the lumen. Here authors report two structures of NDH-1L from Thermosynechococcus elongatus BP-1, in complex with one Fd and an endogenous PQ, respectively.

High-resolution structures of the PSI–LHCI–LHCII supercomplex from Chlamydomonas reinhardtii reveal the mechanism of assembly between the PSI–LHCI complex and two phosphorylated LHCII trimers.

Bacterial photosynthesis reflects the early stages of the evolution of photosynthesis. Here, the authors present a systematic study of the cryo-EM structures of the dimeric light harvesting–reaction center complexes and assembly variants from Rhodobacter sphaeroides, which delineated a hierarchical assembly pathway and quinone transport routes of the dimeric photosynthetic RC–LH1 core complex.

A high-resolution structural study sheds light on processes of energy transfer within the photosynthetic water-splitting machinery of plants.

RNA sequencing of Burkitt lymphoma tumours allows identification of mutations affecting the transcription factor TCF3, its negative regulator ID3 and the cell cycle regulator CCND3; these pathways reveal new targets for potential therapeutic intervention.