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Topological Dirac-vortex modes have attracted broad interest but are thus far limited to two-dimensional photonic systems. Here, authors report the first experimental observation of topological Dirac-vortex modes in a 3D photonic topological insulator.

Cold tolerance at the booting stage is critical for the expansion of rice cultivation area. Here, the authors report that a CAMTA family transcription factor encoding gene CTB3 positively regulates japonica rice booting stage cold tolerance and its upstream and downstream interactors to fulfill the functionality.

The histone methyltransferase ASH1L has been linked to tumorigenesis, mainly in leukemia. Here, authors report that ASH1L cooperates with HIF-1α to induce a pro-metastatic transcriptome in prostate cancer cells, and promotes conversion of monocytes to lipid-associated tumor-associated macrophages in the bone metastatic niche.

Previous ophthalmic foundation models have struggled to generalize effectively to diverse and rare fundus diseases, restricting their clinical applicability. Here, the authors introduce a vision-language foundation model that demonstrates superior performance in diagnosing both common and rare fundus conditions.

Enantioenriched cyclobutenes and cyclobutanes are important units in medicinal chemistry, natural products and material science, and are useful intermediates in organic synthesis. Herein, the authors report a cobalt-catalyzed protocol for pathway-divergent enantioselective coupling of alkynes and cyclobutenes.

Maintaining proper reactive oxygen species (ROS) balance is critical for cellular and individual health, yet its dynamic nature encumbers monitoring and assessment. Here the authors propose a platform using mass cytometry-based detection, termed SN-ROP, to identify distinct ROS profiles associated with specific immune cell functions and disease states.

A product-oriented strategy that leverages the reactivities of different functional groups in real-life plastic mixtures can be used to obtain valuable products, opening a path for managing end-of-life plastic mixtures.

The authors propose a design that equips a programmable metasurface with integrated capability for sensing and manipulating electromagnetic waves, allowing it to leverage the environmental information to enhance wireless system performance in complex environments.

2D Ta-based transition metal dichalcogenides have been predicted to host highly confined plasmons, but their observation has been lacking. Here, the authors report momentum-resolved electron energy loss spectroscopy measurements of 2H-TaS₂ monolayers and bilayers, showing plasmon resonances with lateral confinement up to 300 and group velocity down to ~10⁻⁴c at large wave vectors.

Suppressing charge transport and reducing conduction loss at high temperatures and electric fields is crucial in high-temperature dielectric materials. Here, the authors incorporate high-polarity small molecules into polyetherimide to increase its energetic disorder and reduce charge transport, enabling an energy density of 6.45 J cm-3 with an efficiency of 90%.

Al/CuO/V₂C nanocomposites, created via a novel self-assembly method, show enhanced energy release and safety. Structure varies with V₂C amounts, enabling tunable performance and complete Al oxidation, ideal for microinitiator applications.

Vacuolation has been shown to be possible in super-stoichiometric ratios of the assembling component, but this is not so relevant to biological systems. Here, the authors report the introduction of small, charged motifs for induction of transient vacuolation.

The authors identified a broadly applicable scaling relationship between field emission characteristics and the ratio of apex radius to gap length, and proposed a modified field emission equation suitable for nanoscale applications.

Chronic visceral pain is frequently accompanied by changes in food preference and the underlying neural circuitry mechanisms remain unclear. Here, the authors elucidate a circuit from cholecystokinin neurons in the paraventricular hypothalamus (PVH^CCK) projecting to glutamatergic neurons in the anterior cingulate cortex (ACC^Glu) to regulate food preference accompany with chronic visceral pain.

The epidemic of fat-related metabolic disorders necessitates innovative therapies. Here, the authors show adipose-resident c-kit⁺ cells are crucial brown adipocyte progenitors and provide a promising way to manipulate adult brown adipose tissue for combating obesity and metabolic disorders.

The realization of high-performance flexible perovskite/crystalline-silicon tandem solar cells requires efficient photocarrier transport and mitigation of residual stress. Here, authors reveal the critical role of perovskite phase homogeneity, achieving flexible devices with efficiency of 29.88%.

Significant progress has been made in the field of CRISPR diagnostics, but it is still challenging to achieve multiplexed detection. Here authors exploit CRISPR-Cas12a cis-cleavage to develop a multiplexed assay which includes a portable device incorporating multiplexed PCR, Cas12a cis-cleavage, and lateral flow detection.

Global aging emphasizes the exploration of frailty and depression in relation to incident CVD in middle-aged and older adults. Here, the authors show that frailty is associated with increased CVD risk, partially through depression, with the association influenced by frailty transitions and stronger in males, the elderly, and those with unhealthy lifestyles.

Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data.

Meng et al. demonstrate that RIOK1 phase separation leads to PTEN mRNA sequestration and pentose pathway activation resolving cellular stress in hepatocellular carcinoma. Targeting RIOK1 enhances response to tyrosine kinase inhibitors.

Lilies are popular ornamental and medicinal plants with gigantic genomes. This study reports a high-quality genome assembly of royal lily (Lilium regale), revealing its transposon-driven genome expansion and epigenetic mechanisms for adaptation, offering a resource for lily research and breeding.

The researchers demonstrate direct measurement and complete characterization of structured electronic wave packets created within a prototypical Fano resonance. The method may be broadly applicable to the study of ultrafast processes, especially electronic ones, in complex systems, as well as coherent control of such systems on their fundamental timescales.

This study demonstrates stable photoelectricity-induced halide segregation in epitaxial mixed-halide perovskite microwire networks on mica, verified by in-situ observations. Dynamic segregation-recovery processes and reconfigurable self-powered photoresponse reveal physical computing potential.

Previous work has shown that electronic and structural transitions in VO₂ can be decoupled by realizing an electronic transition within a monoclinic phase. Here, the authors extend this to the rutile phase by demonstrating a photodoping-driven transition from an insulating to a metallic rutile phase.

The mechanism of macrophage cytotoxicity against cancer cells requires further illustration. By employing CRISPR screening in CAR-macrophage and cancer cell co-culture system, the authors identify depletion of ATG9A on cancer cells sensitizes them to macrophage-mediated killing, which can be synergic with CSF1R inhibition in cancer treatment.

The authors realize high dielectric energy storage properties at high temperatures in the polymer nanocomposites via the combined approach of adding high-entropy ferroelectric nanofillers and constructing a bilayer structure.

Certain antimetabolites used to treat cancer are more neurotoxic than others, and it is now shown that this is due to their greater tendency to generate DNA double-stranded breaks, whereas less neurotoxic agents induce single-stranded breaks.

The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

Conventional electrochemical evaluations severely decelerate the iteration of long-life batteries. Here, the authors unpuzzle the myth of coulombic loss contrary to prevailing understanding. Physical-correlated coulombic-capacity relation is pivotal for rapid battery screening and prognostics.

NiFe-based hydroxides are well-known for alkaline water oxidation but face efficiency issues due to unclear Fe dynamics. Here, the authors report that surface Fe dynamics are affected by Fe diffusion on the counter electrode and have developed a zinc-templated precursor to stabilize active Fe sites.

Chiral state transfer typically requires nonadiabatic transitions and ultra-complex experimental control. Here, authors demonstrate a new mechanism arising from basins of attraction, enabling nonlinear chiral-like state transfer with a minimal set of parameters.

Blanc et al. uncover how chronic inflammation triggers an epigenetic switch in aged muscle stem cells, leading to iron accumulation and cell death by ferroptosis—offering insights into muscle aging and potential paths for regenerative therapies.

Controlling droplet motion after impact on solid surfaces is crucial for applications like self-cleaning and microfluidics, yet the fundamental limit of the droplet rebound angle remains unknown. This study reveals a droplet behavior where it rapidly rolls with a rebound angle near zero, defining the lower limit, enabled by asymmetric adhesion on nanostructured surfaces, resulting in greatly enhanced cleaning efficiency and precise droplet transport.

Post-fire dust emissions have increased by 77% globally over the past two decades, and small fires account for 95% of these emissions, according to analysis of satellite observations.

Understanding past warming events is essential to project the consequences of anthropogenic carbon emissions. Here, carbon and hydrological cycle changes of the Carnian Pluvial Episode are revealed, offering insights into Earth System functioning.

It has long been believed that topological phases are solely determined by their lattice structures. Here, the authors report the observation of cavity-tunable topological phases of polaritons by modifying the surrounding photonic environment without altering the lattice structure.

Cities are becoming hotter and brighter. Using satellite data on 428 Northern Hemisphere cities, this study found that artifical night lights outweighed hotter temperatures in lengthening urban growing seasons, with important implications for management.

The hybridization thermodynamics of programmable DNA nanostructures forming metastable loop structures on RNA generate distinct electrical signals during translocation through solid-state nanopores, enabling the identification of single-base alterations.

Efficient adenine base editors for mitochondrial DNA are achieved with evolved TadA deaminases.

Electronic, health-care and energy applications largely rely on miniaturized structures, the fabrication of which, although technically beneficial, is energy intensive and requires the use of hazardous chemicals. Now, research shows an effective bioinspired strategy to reduce such environmental impacts while retaining the benefits of microfabrication.

The synthesis and isolation of compounds featuring lanthanide–carbon triple bonds remain challenging. Now a cluster featuring a cerium–carbon triple bond has been stabilized inside a C₈₀ fullerene cage. The solid-state structure of the compound reveals a cerium–carbon bond distance of 1.969(7) Å.

An outstanding question about the iron-based superconductors has been whether or not their magnetic characteristics are dominated by itinerant or localized magnetic moments. Absolute measurements and calculations of the magnetic response of undoped and Ni-doped BaFe₂As₂ indicate the latter.

Solvent engineering by the addition of 1,4-butane sultone in a perovskite precursor solution simultaneously enhances the crystallization of the perovskite and passivates defects, resulting in a power conversion efficiency of 26.5%.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Xu, Meng, St-Germain et al. report that S1P in HDL induces a calcium signalling cascade involving E-Syt1 that ultimately promotes the formation of contact sites between the endoplasmic reticulum and the plasma membrane, as well as HDL-derived cholesterol transport.

Single cell analysis of histologic variant bladder tumors detects a shared CA125+ tumor cell state associated with aggressive clinical features and reveals enriched expression of TM4SF1, a membrane protein that can be targeted with CAR T cells.

This study integrates a nitrite-adsorbing ionophore into a copper/carbon nanotube electrified membrane, enabling ultrafast and highly selective ammonia production from low-concentration nitrate in real water sources. This cooperative adsorption approach tunes the local catalyst environment to achieve high activity, selectivity and stability without using precious metals or complex synthesis methods.

A platform based on quantum-emitter-embedded metasurfaces with a microcavity that can be tuned by a micro-electromechanical system is demonstrated, enabling dynamic photon emission with narrow bandwidth, ångström-level wavelength tunability and polarization switching.