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The storage of solar wind-derived water of impact glass beads exhibits a dichotomy distribution in the lunar soils.

Boron-containing drug candidates have garnered increasing attention due to their pharmacological properties and application in boron neutron capture therapy. Here, the authors report a transition metal-free anti-addition of pinacolborane to alkynes, facilitated by the counteranion effect for the facile construction of bora-butenolide bioisosteres.

Most of computer-aided design tools in DNA nanotechnology are committed to the scaffolded DNA origami method. Here, the authors present an automated design pipeline BRAIDS for creating DNA wireframe nanostructures based on a scaffold-free molecular self-assembly approach.

Electrochemical organic synthesis is typically conducted in organic media negatively affecting the sustainability of electrosynthesis. Here, the authors realize aggregation-driven electrochemical radical cross coupling of unsaturated compounds using only water as solvent.

An estimate of water abundance in the lunar mantle indicates that the farside mantle is potentially drier than its nearside counterpart.

Marginal liver grafts are associated with a higher risk of graft failure due to their increased susceptibility to ischemia-reperfusion injury. Here, the authors show the regulatory mechanism of fibroblast growth factor 21 and offer insights into its clinical application in early liver graft injury.

Parvimonas micra (P. micra) is an oral opportunistic pathogen frequently present in oral lesions and infections. Here, authors report that P. micra promotes oral squamous cell carcinoma metastasis by regulation HIF-1α-induced glycolysis and autophagy following TmpC protein binding to CKAP4 receptor.

Controlling the enantioselectivity of radical reactions is a persistent challenge in organic synthesis. Here, the authors report a method to form asymmetric pyridine derivatives via the combination of chiral palladium catalysis and electrochemistry.

The electroreduction of nitrogen to ammonia offers a promising alternative to the Haber–Bosch process but suffers from low activity and selectivity. Here, authors demonstrate that triggering a salting-out effect in a highly concentrated electrolyte can achieve highly efficient ammonia synthesis.

LYTAC strategies often face challenges in solid tumor penetration and synthesis. Here, the authors introduce Pep-TACs, a modular TFRC-based covalent peptide degradation platform that effectively degrades membrane protein PD-L1. This approach significantly suppresses both anti-PD-1-responsive and -resistant tumor growth, particularly in brain tumors.

Deep-sea dissolved organic carbon is significantly removed within hadal trenches, positioning these regions as critical sinks in the global DOC pool and highlighting a potential coupling between the marine carbon cycle and tectonic activity.

A sugar transporter OsSTP28 is identified as a regulator of nitrogen-response tillering and yield formation in rice. Nitrogen supply represses the expression of OsSTP28 to fine turn the level of apoplastic glucose in shoot base, which in turn activates gibberellin catabolism.

Second near-infrared (NIR-II) fluorescence imaging is promising for real-time surveillance of surgical operations, but its clinical uses have been limited by the safety and cost concerns associated with lasers or X-rays. Here the authors report the engineering and applications of white-light activatable organic nanomaterials with bright NIR-II emission.

Congenital vertebral malformation has a complex genetic architecture that isn’t fully understood. Here, the authors explore the genetic architecture of congenital vertebral malformation through case-control rare variant genetic analyses and embryonic transcriptome analyses of the developing spine.

Polymer dielectric capacitors are important for energy storage, although they often suffer from low energy density, especially at high temperatures, and challenges in mass production. This study reports roll-to-roll fabricated composites enriched with subnanosheet fillers, showcasing enhanced performance even at elevated temperatures.

Earthquakes enhance dissolved carbon production and fuel the microbial activities in hadal trench subsurface sediments, and ultimately strengthen carbon accumulation and transformation in the subduction zones.

Studies of fruit quality traits in pears are lagging behind the other major fruit trees. Here, the authors conduct GWAS of fruit quality and phenological traits in a panel of 312 sand pear accessions using SNPs called from resequencing data, and reveal the involvement of a lignin formation-related protein in regulating stone cell development.

Maternal high-fat diet alters the gut microbiota of offspring, reduces tryptophan metabolites and disrupts the intestinal mucus barrier via LRRC19, while LRRC19 deletion restores barrier function.

Doping strategies have been shown to stabilize the active platinum-nickel (PtNi) catalyst in fuel cells, however, the atomistic mechanism is less known. Here, the authors identify the roles of Mo and Au dopants in improving the durability of a PtNi nanowire catalyst for fuel cells.

Providing large-scale iodide capped semi-conductive PbS nanocrystals inks preparation for high-throughput manufacturing remains a challenge. Here, the authors propose a direct one step and scalable synthesis method enabling cost reduction and promoting its commercial viability for solar cells.

AMPK is regulates cellular energy and has been extensively studied, although our knowledge of downstream substrates is incomplete. Here, Chen et al. perform global quantitative analysis for AMPK-dependent sites and validate one hit, ARMC10, as a direct AMPK effector of mitochondrial dynamics.

The Review discusses the state-of-the-art polymer nanocomposites from three key aspects: dipole activity, breakdown resistance and heat tolerance for capacitive energy storage applications.

Smartphone-based mobile health platforms have drawn increasing attention from researchers developing point-of-care testing devices. Here the authors summarize recent progress and future directions of approaches combining microfluidics and artificial intelligence.

Frequency dependent impairment degrades the transmission performance but its accurate calibration is still challenging due to the complex polarization. Dai, Zhang and colleagues report a calibration method able to simultaneously calibrate various frequency-dependent impairments in coherent optical transceivers, with a measured bit error rate improvement from 1.61e^-1 to 4.41e^-2 after calibration.