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Zhang et al. show that the activation of RIPK1 is suppressed by acetylhypusination in a spermidine-dependent manner. Disruption of this axis contributes to RIPK1-mediated vascular pathology to promote insulin resistance and diabetic kidney pathology.

Using human data and mice models, it was revealed that assimilation of ammonia by a gut microbe prevents its harmful accumulation that can impair kidney function.

There is a critical gap in understanding the full spectrum of health effects associated with NO_x exposure. Here, the authors find using UK Biobank data that mortality from all-cause, non-accidental and other 20 specific diseases was significantly associated with NO_x.

A dual-additive crystallization method using PyNI and 5AVA as additives results in highly efficient 3D perovskite films with enhanced photoluminescence quantum efficiencies and external quantum efficiencies, and hence increased LED performance.

Diagnosis of lung cancer from indeterminate pulmonary nodules remains challenging. Here, the authors develop a multi-omics signature to identify oncogenic nodules, and prevent unnecessary procedures.

Light-emitting diodes based on halide perovskites have made remarkable progress but their stability is the bottleneck. Here Miao et al. show 14% quantum efficiency at a current density of 300 mA cm-2 and 23.7 hr lifetime under a current density of 100 mA cm-2, making it promising for actual application.

The sperm flagellum is composed of tubulin-based microtubules and is critical for sperm motility and thus male fertility. Here, the authors show that STYXL1 regulates CCT complex-facilitated tubulin folding and is essential for sperm flagella formation.

A biochemical and structural analysis demonstrates that alterations at the substrate-binding pocket of the main protease of SARS-CoV-2 can allow the virus to develop resistance to nirmatrelvir in two distinct ways.

Genome and transcriptome analyses of 376 Gossypium hirsutum accessions uncover the regulation of gene expression during fiber development in allotetraploid cotton and highlight the potential for fiber quality improvement.

Induced pluripotent stem cell (iPSC)-derived macrophages (iMACs) are being used to make chimeric antigen receptor (CAR) macrophages for immunotherapy. Here the authors design a second-generation macrophage-specific CAR by integrating CD3ζ and toll/IL-1R (TIR) domains resulting in an M1-polarized CAR-iMAC with increased antitumor functions.

The authors cloned anti-NMDAR (N-methyl-d-aspartate receptor) monoclonal antibodies from the immune B cells of persons with autoimmune encephalitis and revealed their precise binding epitopes on NMDARs and the pathological mechanism underlying the downregulation of synaptic function.

In vivo manipulation of the dynamics of nanoparticles’ is essential for disease-specific imaging and therapy, but tends to involve complex design processes. Here, the authors report a strategy for manipulating the assembly of nanoparticles in vivo through a self-catalysis-instructed dimerization of tyrosine, offering convenient fabrication, high reaction specificity and biocompatibility.

Addressing mass and electron transfer challenges hinders practical application of photoelectrochemical (PEC) devices. Here, authors report a simulation-guided development of hierarchical triphase diffusion photoelectrodes, achieving an improved mass transfer and ensuring electron transfer for PEC gas/liquid flow conversion.

Using machine learning, the authors reveal that stable background conditions explain most variation in armed conflict risk worldwide. Positive temperature deviations and precipitation extremes also increase the risk of conflict onset and incidence.

Spatially selective actuation and large output force enables versatile task performance in soft robotics. Here, the authors report a method for actuating untethered soft robots using focused ultrasound waves to perform liquid cargo delivery and biopsy.

Single-cell RNA sequencing is used to generate a dataset covering all major human organs in both adult and fetal stages, enabling comparison with similar datasets for mouse tissues.

Plants can rapidly close stomata to restrict pathogen entry into leaves. Here the authors show that phosphorylation of villin3 by mitogen-activated protein kinases modulates actin remodeling to activate stomatal defense in Arabidopsis.

Decreased host glucose levels upon Yersinia pseudotuberculosis infection activate AMPK, leading to RIPK1 inhibition and suppression of pyroptosis to exacerbate disease outcomes in mice.

Structural colors arise from nanostructures or special microgeometries. Here, the authors report on crescent-shaped microparticles as full-color reflective pigments that show brilliant colors in directional light and are transparent in ambient light.

The regulation of PD-L1 via proteasomal degradation is unclear. Here, the authors show that EGFR inhibition activates GSK3 α to promote PD-L1 phosphorylation, which leads to PD-L1 ubiquitination and proteasome mediated degradation by ARIH1 E3 ligase.

The adaptor protein TRADD is a regulator of both cellular homeostasis and apoptosis, and represents a potential therapeutic target for human diseases.

Understanding the catalytic mechanism of bimetallic nanocatalysts remains challenging. Here the authors demonstrate that the d-orbital charge on the surface of Pd in a well-defined AuPd nanoalloy serves as a descriptor to the adsorbate states and hence the catalytic performance.

Applications of perovskite solar cells have been hindered by ion migration and structural instability. Here, the authors use ultra-low dose transmission electron microscopy to reveal the process of ion migration and structural change at the atomic level in Cs_1-xFA_xPbI₃.

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

RIPK1 is a critical kinase which mediates necroptosis, apoptosis and inflammation. Regulation of RIPK1 by ubiquitination is being intensively investigated. Here, the authors made knock-in RIPK1-K612R mice and demonstrate that this mutation alters the RIPK1 ubiquitinylation pattern and inhibits its prodeath kinase activity in response to TNFα but sensitizes cell death to TLRs signals.

Few-layered black phosphorus has unique and appealing electronic properties but is easily oxidized in air. Here, the authors covalently functionalize black phosphorus nanosheets with C₆₀ at their edges, providing improved stability and enhanced photoelectrochemical and photocatalytic activities.

Genetic variation from coexisting species influences interspecific interactions in a community. Here, the authors develop a framework for identifying quantitative trait loci (QTLs) underlying community dynamics and validate the tool using data from co-culturing of two bacterial species.

Mitogen-associated protein kinases are central in the signalling pathway that allows secondary roots to cross through the outer tissue layers before emerging.

NEK1 mutations promote lethality early in life and ALS late in life via unknown mechanisms. Here, the authors show that NEK1 mutation disrupts retromer-mediated trafficking and promotes RIPK1 activation, connecting retromer trafficking and metabolism to neuroinflammation by dietary intervention.

A molecular model of STING-mediated signalling is proposed, as structural analysis identifies a crucial motif for the binding of TBK1 to STING, and a separate model involved in IRF-3 binding.