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Inflammatory diseases may play an important role in lung cancer in never-smokers (LCINS) pathogenesis. Here, the authors show that conditions such as GERD or COPD could be considered as part of eligibility criteria for LCINS screening programs in the future.

Silicon (Si) has emerged as a promising next-generation anode material. Here the authors recycle photovoltaic waste for micro-sized Si that can pair with high-voltage cathode for high-performance Li-ion pouch cells.

Covalent organic frameworks (COF) hold great promise in filtration and separation but combining facile processing, high crystallinity and high separation performance remains challenging. Here, the authors demonstrate that heterocrystalline COF membranes in which high-crystalline regions are tightly linked by low-crystalline regions can improve molecular sieving properties at high solvent flux.

Chemotherapy-dominated multi-modal therapeutic strategy has the potential for eradicating colorectal tumors. Here this group reports a therapeutic strategy using arsenic-derived nanosheets depleting H2S enriching in CRC microenvironment while eliciting the photothermal activity/cytotoxicity of ultrasmall CuS nanoparticles against CRC cells.

Covalent organic framework (COF) membranes are important in low energy and cost-effective molecular separations but most COF membranes are assembled via a one-step procedure by concurrent polymerization and crystallization which compromises the ordered structure. Here, the authors propose a two-step phase switching strategy for assembling compact and highly crystalline COF membranes decoupling the polymerization and the crystallization process.

The ability of anti-cancer therapies such as radiotherapy, chemotherapy and immunotherapy to induce ferroptosis has been linked to their efficacy. Here, the authors demonstrate that SOX13 promotes ferroptosis-resistance via transactivation of SCAF1, identifying SOX13 as a targeted therapeutic vulnerability in gastric cancer.

Hetero-oligomeric TRP-like channels such as PKD1L3/PKD2L1 play crucial roles in a range of physiological and pathophysiological processes. Here, the authors present the cryo-EM structures of a minimal functional murine PKD1L3/PKD2L1 complex in the absence and presence of calcium and further supported through structure-guided mutagenic studies, they discuss the mechanism of calcium-induced channel activation.

A comprehensive understanding of the transient characteristics in solid oxide cells is crucial when integrated with intermittent renewable energy. Here, authors reveal expressions for two general characteristic times quantifying transient phenomena due to heat and mass transfer lags in SOCs.

A Phase 2, randomized, placebo-controlled study evaluated novel GLP-1 analog ecnoglutide in adults with type 2 diabetes. Here we show that ecnoglutide significantly reduced HbA1c from baseline up to -2.39% compared to -0.55% for placebo (P<0.0001), with a safety profile similar to approved GLP-1 analogs.

Methylmalonic acid (MMA) is increased in aging as well as produced by advanced tumors, and can drive pro-aggressive changes in these tumor cells. Here, the authors show that MMA can also act on fibroblasts in the tumor microenvironment, recruiting and activating them to further support tumor progression.

Remote tumours cause liver dysfunction by releasing extracellular vesicles and particles containing palmitic acid, which induces TNF signalling in Kupffer cells, resulting in inflammation, fatty deposits and metabolic dysregulation, thus both reducing the efficacy and increasing the toxicity of chemotherapies.

Whole-genome sequencing of lung cancer in never smokers identifies different copy number subtypes and shows a lack of tobacco smoking signatures, even in cases exposed to secondhand smoke.

The value-added electrochemical conversion of ethylene glycol using noble metal catalysts is often hindered by rapid deactivation. In this study, the authors present a dynamic potential cycling method that effectively suppresses oxide-induced deactivation and enhances both catalyst activity and stability.

Tuning electrocatalytic reduction of carbon monoxide to achieve valuable ethanol product with high performance is interesting yet challenging. Here, the authors design a hydrophobic Cu/Cu₂O sheet catalyst showing a FE of 68.8% and partial current density of 111 mA cm⁻² for CO reduction to ethanol.

A copper(II)-functionalized Mycobacterium smegmatis porin A nanopore enables direct identification of all 20 proteinogenic amino acids, one unnatural amino acid and two post-translational modifications, and shows potential for peptide discrimination and sequencing.

There is interest in STING for immunotherapy, but it suffers from adverse proinflammatory effects. Here, the authors report on a non-membrane-associated polymeric universal STING mimic which triggers pathways involved in tumour control over proinflammatory pathways, demonstrating application in vivo.

Wu et al. optimized the m⁶A mapping method for ultralow-input materials and characterized the transcriptome-wide landscape of m⁶A methylation in mouse oocytes and early embryos.

The E1A binding protein p300 and its close paralogue CREB-binding protein are transcriptional coactivators with intrinsic histone acetyltransferase activity. Here, the authors show that the TAZ2 ___domain of p300 has a HAT autoinhibitory function that is relieved upon binding of transcription factors.

HRG-9 (also known as TANGO2) is an evolutionarily conserved haem chaperone that traffics haem from sites of storage or synthesis in eukaryotic cells.

Activated hepatic stellate cells are associated with fibrosis and liver metastases. Here, the authors identify an endogenous role of relaxin in regulating the activation of hepatic stellate cells and report nanoparticle-mediated relaxin gene therapy to mitigate fibrosis and liver metastasis.

Identification of low abundance proteins interacting with viral proteins can be challenging. Here, Du et al. develop an mRNA display approach with a library of even distribution, identify host proteins interacting with NS1 protein of influenza A virus, and show that one interactor provides a means to regulate cellular fatty acids synthesis.

Energy-efficient and secure wireless body sensor networks can be created by using conductive fabrics that support surface-plasmon-like modes at radio communication frequencies.

Yu, Zhou, Cao, He et al. show that BMP4 reconfigures the nuclear architecture during the transition from primed to naive pluripotency by targeting Zbtb7a and Zbtb7b, which encode proteins that mediate the opening of naive chromatin loci.

The hormone peptide relaxin attenuates liver fibrosis by inducing quiescence of activated hepatic stellar cells. In this paper the authors show that hepatic macrophages play a key role in mediating the antifibrotic effects of relaxin in animal models and propose a nanotechnology-based approach to alleviate liver fibrosis.

Th17 cells are a common pathogenic effector cell in autoimmune inflammatory diseases. Here the authors show that the transcription factor RFX1 limits Th17 differentiation and is protective against the pathogenesis of Th17-driven autoimmune diseases.

Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in hepatic steatosis worsening and HCC development via metabolic and immune reprogramming.

Somatosensory corticospinal neurons facilitate touch sensitivity and touch-evoked neuropathic pain in mice.