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Expanding editing scope while reducing byproducts is now possible for prime editing. Here, authors develop reverse prime editing (rPE), a SpCas9-based tool enabling editing in reverse window with high fidelity and demonstrate its use in inserting therapeutic variants.

Lithium-ion batteries often struggle to maintain capacity in extreme cold conditions. Here, authors develop amorphous solid electrolytes (xLi₃N-TaCl₅) with high ionic conductivities and design all-solid-state batteries capable of operating at ‒60 °C for over 200 hours.

Economic development and its interactions with the SDGs is an important focus for sustainable future growth. This paper develops six environmental footprint indices highlighting the synergies with human production and the SDG targets.

A base editing study in poplar shows that synergistic optimization of a cytosine base editing system (hyPopCBE-V4) enhances C to T editing efficiency and precision, reduces byproducts, and yields herbicide-resistant germplasm, providing a tool for tree breeding.

Alkyne hydrogenation is important for producing industrially relevant materials. Here, the authors illustrate why most Cu-based electrocatalysts favor alkyne hydrogenation toward alkene and discuss how to design catalysts which favor alkane formation.

Nanowires and nanotubes are ideal candidates for energy applications but inorganic multielement oxides are less well studied. Here, the authors propose a gradient-electrospinning followed by controlled-pyrolysis method to synthesize various controllable one dimensional metal oxide nanostructures.

The growing global demand for agricultural products from specific regions leads to farming practices that can exacerbate soil-phosphorus depletion, with consequences for long-term food security. This study quantifies the contribution of trade to global soil-phosphorus deficits from 1970 to 2017.

Salmonella is a significant cause of gastrointestinal infection and asymptomatic carriage can contribute to transmission. Here, the authors investigate the prevalence of asymptomatic carriage of Salmonella in Yulin, China through occupational health screening and find that carriage was higher in food workers.

Schrank et al. report the design and characterization of an antibody–toxin conjugate targeting CD47, promoting anti-tumor immunity in preclinical cancer models.

The molecular mechanism of LAP activation against invading pathogens is not fully understood. Here the authors demonstrate that programmed cell death 6 (PDCD6) negatively regulates LAP formation and the antibacterial response by interacting with lactate dehydrogenase A (LDHA) to downregulate lactate metabolism and RUBCN lactylation-mediated signaling.

Crumpled graphene structures are promising for electrochemical energy storage. Here, the authors synthesize deeply crumpled pinecone-like graphene sheets, which show self-adaptive folding-unfolding behaviours in cycling leading to robust battery performances.

Staple crop production in China involves high levels of synthetic fertilizer use and losses to the environment. Using a localized nitrogen management model for wheat, maize and rice, this study estimates the environmental and economic benefits of improving nitrogen use efficiency at the county level.

This study identifies the flows of physical and virtual nutrients (N and P) within the global agricultural trade network by trade tracing, and explores strategies to improve global nutrient use efficiency using the telecoupling framework.

A 2D Czochralski method is introduced for rapidly growing centimetre-scale single-crystal MoS₂ domains with low defect density and impressive electrical performance. This method shows potential for fabricating high-quality and scalable 2D semiconductor materials and devices.

Here the authors elucidate the epigenetic basis underlying the activation of PVR-associated genes during RPE cell fate transitions and offers potential therapeutic avenues targeting epigenetic modulation and the RANK-NFATc1 axis for PVR management.

There are intensive efforts in developing anode materials for sodium-ion batteries. Here, the authors present a graphene-titanium dioxide composite as an anode material and show that sodium ion intercalation pseudocapacitance charge storage leads to excellent electrochemical properties.

ASB7 acts as the substrate receptor for cullin 5 RING E3 ubiquitin ligase (CRL5), targeting the internal α-helix degron for degradation. Here, the authors elucidate the molecular mechanism of substrate recognition by ASB7 using structural, biochemical and cellular analyses.

The intestinal symbiont Desulfovibrio, which is enriched in individuals with metabolic syndrome, is found to suppress the production of GLP-1 in male mice. The over-the-counter drug bismuth subsalicylate inhibits the effect of Desulfovibrio and restores GLP-1 levels.

Understanding the in vivo biotransformation of nanomaterials used for biomedical applications might shed light on their long-term effects and safety. Here the authors show that molybdenum derived from nanomaterials is mainly transported in the liver, in a corona-mediated process, and is incorporated in molybdoenzymes, with an effect on liver metabolism.

Managing natural systems to mitigation climate change is a key strategy for limiting warming. In China, such natural climate solutions could offset 6% of CO₂ emissions during 2020–2030, contributing to mitigation goals but highlighting the importance of emissions reductions.

The gut microbiome affects systemic metabolism and is a therapeutic target for type 2 diabetes. Here the authors demonstrate in a randomized controlled trial that effects of berberine, a plant alkaloid known to lower blood glucose, may be explained by the inhibition of Ruminococcus bromii mediated biotransformation of the bile acid deoxycholic acid.

Photosystem I (PSI) is one of two large pigment–protein complexes responsible for converting solar energy into chemical energy. This study reveals the previously unknown major PSI assembly pathway in land plants.

The hydrophobicity, electrostatic charge and secondary conformation of helical polypeptides can be optimized to stimulate antitumour innate immune responses via endoplasmic reticulum stress in antigen-presenting cells.

The contribution of transportation to food systems’ total carbon footprint varies widely depending on calculation methods, indicating different priorities for climate change mitigation in the sector. Here, a global multi-region accounting framework that estimates food-miles and associated emissions over the whole supply chain shows the benefits of localizing food production.

Singh and colleagues show that PDAC phenotypic plasticity is regulated via AP1 enhancer remodeling and modulated by TNF-α⁺ macrophages and pharmacological inhibition of the BRD4–cJUN–CCL2–TNF-α axis restores favorable PDAC subtypes and prognosis.

Near-infrared perovskite light-emitting diodes with extrapolated device lifespans on the scale of years are achieved by the use of a dipolar molecular stabilizer.

The role of international trade in achieving the UN Sustainable Development Goals is complex and affects multiple factors differently depending on the development context of each country. This study analyses historic trends and shows how global trade can either promote or hinder progress towards the Sustainable Development Goals.

Laser-based micro-focused angle-resolved photoemission spectroscopy reveals both fractionalized and marginal quasiparticles in C₃-symmetric electron pockets near the Brillouin zone centre of the ferromagnetic kagome metal Fe₃Sn₂.

An inverter that uses a self-biased molybdenum disulfide homojunction as the load and n-type transistor as the driver can exhibit lower static power than complementary metal–oxide–semiconductor (CMOS) or pseudo-n-type metal–oxide–semiconductor (NMOS) architectures.

Low-cost targeted approach to construct haplotype-resolved assemblies is needed to facilitate population genetic studies. Here, the authors demonstrate assembling high-quality MHC haplotypes with CRISPR-based enrichment and long-read sequencings.

Perovskite light emitting diodes suffer from operational stability, showing rapid decay of performance within minutes to hours after turn-on. Here, the authors investigate how the steric and Coulomb interaction of ammonium passivation molecules with varying alkyl chain length can improve device stability by suppressing iodide ion migration.

The complex nature of food supply chains makes it a crucial exercise to estimate the impacts of disruptions caused by climate disasters. By applying an integrated modelling framework to Australia and considering heatwaves, cyclones and other climate events, this study presents novel ways of quantifying regional and sectoral spillover effects—including job and income losses, food and nutrient availability, and diet quality.

Valley anisotropy is proposed theoretically to benefit the electrical transport of thermoelectric materials but it lacks experimental demonstration. Here, the authors demonstrate how to utilize the single anisotropic Fermi pocket in p-type Mg₃Sb₂ to enhance its thermoelectric properties.

There is an emerging interest in the use of mRNA therapeutics in cancer treatment, but their precise in vivo delivery remains a challenge. Here the authors develop IFN-γ mRNA-loaded small extracellular vesicles (sEVs) with CD64 overexpressed on their surface and demonstrate its efficacy in glioblastoma mouse models resistant to immunotherapy.