Nature Search

Genetic diversity fuels gene discovery for tobacco and alcohol use

A multi-ancestry meta-regression study analyses diverse genome-wide association studies and genome loci associated with tobacco and alcohol use.

Gretchen R. B. Saunders
Xingyan Wang
Scott Vrieze
ResearchOpen Access07 Dec 2022
Nature

Volume: 612, P: 720-724
IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma

Chengtao Sun
Mengzhen Li
Yizhuo Zhang
ResearchOpen Access27 Jun 2022
Cell Death & Disease

Volume: 13, P: 1-13
Research on the mechanism of the influence of family socioeconomic status on the Cardinal principle of young children

Huanhuan Li
Bingyu Duan
Enwei Xu
ResearchOpen Access05 Jun 2025
Scientific Reports

Volume: 15, P: 1-14
Correction: Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming

Zhangnan Liu
Mengzhen Fan
Huijuan Wang
Amendments and CorrectionsOpen Access06 Mar 2023
Cell Death & Disease

Volume: 14, P: 1
Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants

In this study, authors identified neutralizing antibodies by isolating B cells from SARS-CoV-2 Delta infected patients and detect altered structural features, likely introduced by somatic hypermutation, that are involved in epitope binding and increase neutralization breadth against virus variants.

Haisheng Yu
Banghui Liu
Xiaoping Tang
ResearchOpen Access24 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Model-based assessment of replicability for genome-wide association meta-analysis

In genome-wide association meta-analysis, it is often difficult to find an independent dataset of sufficient size to replicate associations. Here, the authors have developed MAMBA to calculate the probability of replicability based on consistency between datasets within the meta-analysis.

Daniel McGuire
Yu Jiang
Dajiang J. Liu
ResearchOpen Access30 Mar 2021
Nature Communications

Volume: 12, P: 1-14
Comparing interpretable machine learning models for fall risk in middle-aged and older adults with and without pain

Shangmin Chen
Yongshan Gao
Zhigang Zhong
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-9
Potential role of hypobaric hypoxia environment in treating pan-cancer

Shixuan Zhang
Xiaoxi Hu
Zixin Hu
ResearchOpen Access15 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
Development of a novel core genome MLST scheme for tracing multidrug resistant Staphylococcus capitis

Staphylococcus capitis is a common causative agent of bloodstream infections in neonatal intensive care units, with multidrug resistant isolates complicating treatment. Authors aimed to establish a core genome multilocus sequence typing (cgMLST) scheme to document the transmission and dissemination of multidrug-resistant S. capitis isolates.

Zhengan Wang
Chao Gu
Yunsong Yu
ResearchOpen Access22 Jul 2022
Nature Communications

Volume: 13, P: 1-8
An in vitro evaluation of antimicrobial activity of a fast-setting endodontic material

Mengzhen Ji
Yaqi Chi
Ling Zou
ResearchOpen Access26 Sept 2022
Scientific Reports

Volume: 12, P: 1-5
Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

A genome-wide association study suggests 41 previously unreported loci on top of the 23 known loci that influence the disease risk for lumbar disc herniations. Many of these loci harbour genes implicated in disc structure and inflammation, as well as genes related to the nervous system and nerve function.

Ville Salo
Juhani Määttä
Johannes Kettunen
ResearchOpen Access07 Nov 2024
Nature Communications

Volume: 15, P: 1-14
Promoting biomass electrooxidation via modulating proton and oxygen anion deintercalation in hydroxide

Developing catalysts for biomass electrooxidation are critical in electric refinery. The reaction mechanism, however, is still ambiguous. Here, the authors reveal how proton and oxygen anion deintercalation in hydroxide determine the elementary reaction steps in a model reaction of glycerol oxidation.

Zuyun He
Jinwoo Hwang
Yan Chen
ResearchOpen Access30 Jun 2022
Nature Communications

Volume: 13, P: 1-10
Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Narcolepsy has genetic and environmental risk factors, but the specific genetic risk loci and interaction with environmental triggers are not well understood. Here, the authors identify genetic loci for narcolepsy, suggesting infection as a trigger and dendritic and helper T cell involvement.

Hanna M. Ollila
Eilon Sharon
Emmanuel J. Mignot
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-13
Exploring the income impact of rural e-commerce comprehensive demonstration project and determinants of county selection

Mengzhen Wang
Xingong Ding
Pengfei Cheng
ResearchOpen Access27 Sept 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-11
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Association studies of up to 1.2 million individuals identify 566 genetic variants in 406 loci associated with tobacco use and addiction (initiation, cessation, and heaviness) as well as alcohol use, with 150 loci showing pleiotropic association.

Mengzhen Liu
Yu Jiang
Scott Vrieze
Research14 Jan 2019
Nature Genetics

Volume: 51, P: 237-244
Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

The burden of mosaic chromosomal alterations in blood-derived DNA, a type of clonal hematopoiesis, is associated with an increased risk for diverse types of infections, including sepsis and pneumonia.

Seyedeh M. Zekavat
Shu-Hong Lin
Pradeep Natarajan
Research07 Jun 2021
Nature Medicine

Volume: 27, P: 1012-1024
Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Many genetic factors that contribute to uterine leiomyomata (UL) - the most common tumours of the female genital tract - remain to be discovered. Here, the authors conduct a UL meta-genome-wide association study, and find loci related to altered muscle tissue biology that are associated with UL.

Eeva Sliz
Jaakko S. Tyrmi
Johannes Kettunen
ResearchOpen Access01 Feb 2023
Nature Communications

Volume: 14, P: 1-14
Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

This paper identified >500 genetic loci associated with behaviors and disorders related to self-regulation, including addiction and child behavior problems. The resulting genetic risk scores predict several behavioral, medical and social outcomes.

Richard Karlsson Linnér
Travis T. Mallard
Danielle M. Dick
Research26 Aug 2021
Nature Neuroscience

Volume: 24, P: 1367-1376
Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming

Zhangnan Liu
Mengzhen Fan
Huijuan Wang
ResearchOpen Access20 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-11
Axial mechanical properties of welded orthogonal trapezoidal aluminum honeycomb as filler material for nuclear equipment impact limiter

Youdong Xing
Baixing Deng
Siyi Yang
ResearchOpen Access12 Nov 2024
Scientific Reports

Volume: 14, P: 1-17
Achieving the Heisenberg limit in quantum metrology using quantum error correction

The possibility to reach Heisenberg-limited quantum measurements in the presence of noise is a long-standing problem. Here, the authors derive a necessary and sufficient condition on the noise acting on any finite-dimensional probe to establish whether the Heisenberg limit is reachable using quantum error correction.

Sisi Zhou
Mengzhen Zhang
Liang Jiang
ResearchOpen Access08 Jan 2018
Nature Communications

Volume: 9, P: 1-11
SUV39H1 epigenetically modulates the MCPIP1-AURKA signaling axis to enhance neuroblastoma tumorigenesis

Mengzhen Li
Feifei Sun
Yizhuo Zhang
ResearchOpen Access19 Sept 2024
Oncogene

Volume: 43, P: 3306-3320
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation

Tao Zhang
Zilu Pan
Hua Xie
ResearchOpen Access15 Aug 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-17
Hirschsprung’s disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3β

Yang Yang
Mengzhen Zhang
Kai Wu
Research24 Apr 2024
Pediatric Research

Volume: 96, P: 942-951
Narcolepsy as a potential risk factor for Schizophrenia

Reyhane Eghtedarian
Anniina M. Tervi
Hanna M. Ollila
ResearchOpen Access17 Feb 2025
Translational Psychiatry

Volume: 15, P: 1-10
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

A. Mesut Erzurumluoglu
Mengzhen Liu
Joanna M. M. Howson
ResearchOpen Access07 Jan 2019
Molecular Psychiatry

Volume: 25, P: 2392-2409
Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure

Jitai Zhang
Hui An
Ming Li
ResearchOpen Access11 Apr 2019
Cell Death & Disease

Volume: 10, P: 1-13
Novel loci and biomedical consequences of iron homoeostasis variation

The largest meta-analysis of GWASs of hepcidin and sTfR identified 43 genomic loci, of which 15 new. Mendelian randomisation revealed associations of systemic iron status and iron-related loci with selected health outcomes across multiple domains.

Elias Allara
Steven Bell
Emanuele Di Angelantonio
ResearchOpen Access06 Dec 2024
Communications Biology

Volume: 7, P: 1-17
City-level population projection for China under different pathways from 2010 to 2100

Shangchen Zhang
Mengzhen Zhao
Wenjia Cai
ResearchOpen Access17 Nov 2023
Scientific Data

Volume: 10, P: 1-9
Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway

The MetE like complex is found to be capable of regulating the PKS system to produce EPA in Schizochytrium, with its activation regulating the expression of key enzymes, improving the efficiency of DHA and EPA production.

Wang Ma
Mengzhen Liu
He Huang
ResearchOpen Access09 Dec 2022
Communications Biology

Volume: 5, P: 1-11
DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6

Xiaochao Zhang
Yabing Hu
Bixiang Zhang
ResearchOpen Access09 Feb 2022
Oncogene

Volume: 41, P: 1821-1834
NTHL1 is a recessive cancer susceptibility gene

Anna K. Nurmi
Liisa M. Pelttari
Heli Nevanlinna
ResearchOpen Access30 Nov 2023
Scientific Reports

Volume: 13, P: 1-14
Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

A genome-wide association study identifies MFGE8 as protective against coronary atherosclerosis in European and East Asian populations.

Sanni E. Ruotsalainen
Ida Surakka
Samuli Ripatti
ResearchOpen Access17 Aug 2022
Communications Biology

Volume: 5, P: 1-16
A FinnGen pilot clinical recall study for Alzheimer’s disease

Valtteri Julkunen
Claudia Schwarz
Heiko Runz
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-15
Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

Max Tamlander et al. combine polygenic risk scores and clinical assessments to improve prediction of coronary artery disease and type 2 diabetes in European cohorts. Taken together, their results provide a useful method for preliminary cardiometabolic risk assessment in patients.

Max Tamlander
Nina Mars
Samuli Ripatti
ResearchOpen Access23 Feb 2022
Communications Biology

Volume: 5, P: 1-13

Search

Genetic diversity fuels gene discovery for tobacco and alcohol use

IDO1 plays a tumor-promoting role via MDM2-mediated suppression of the p53 pathway in diffuse large B-cell lymphoma

Research on the mechanism of the influence of family socioeconomic status on the Cardinal principle of young children

Correction: Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming

Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants

Model-based assessment of replicability for genome-wide association meta-analysis

Comparing interpretable machine learning models for fall risk in middle-aged and older adults with and without pain

Potential role of hypobaric hypoxia environment in treating pan-cancer

Development of a novel core genome MLST scheme for tracing multidrug resistant Staphylococcus capitis

An in vitro evaluation of antimicrobial activity of a fast-setting endodontic material

Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

Promoting biomass electrooxidation via modulating proton and oxygen anion deintercalation in hydroxide

Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Exploring the income impact of rural e-commerce comprehensive demonstration project and determinants of county selection

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection

Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming

Axial mechanical properties of welded orthogonal trapezoidal aluminum honeycomb as filler material for nuclear equipment impact limiter

Achieving the Heisenberg limit in quantum metrology using quantum error correction

SUV39H1 epigenetically modulates the MCPIP1-AURKA signaling axis to enhance neuroblastoma tumorigenesis

Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation

Hirschsprung’s disease: m6A methylase VIRMA suppresses cell migration and proliferation by regulating GSK3β

Narcolepsy as a potential risk factor for Schizophrenia

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure

Novel loci and biomedical consequences of iron homoeostasis variation

City-level population projection for China under different pathways from 2010 to 2100

Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway

DDR1 promotes hepatocellular carcinoma metastasis through recruiting PSD4 to ARF6

NTHL1 is a recessive cancer susceptibility gene

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

A FinnGen pilot clinical recall study for Alzheimer’s disease

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes

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