MUTYH removes A mis-incorporated opposite oxidized guanine to thwart mutations. Here, the authors present crystal structures and assess functional impacts and molecular dynamics of cancer-linked variants to illuminate how the [4Fe-4S] cofactor and active site are allosterically connected with significance for fidelity and clinical impact.
- Carlos H. Trasviña-Arenas
- Upeksha C. Dissanayake
- Sheila S. David