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Showing 1–2 of 2 results
Advanced filters: Author: Micah A. Gygi Clear advanced filters

  • A disulfide tethering screen identified a molecule that covalently interacts with pro-apoptotic BAX at C126, inhibiting its activation.

    • Matthew W. McHenry
    • Peiwen Shi
    • Loren D. Walensky
    Research
    Nature Chemical Biology
    Volume: 20, P: 1022-1032

  • Prew et al. uncovered a structural basis for human VLCAD deficiency that arises from point mutations within the enzyme’s membrane-binding region, which was shown to fold as a putative α-helical hairpin. Helix-breaking mutations selectively disrupt membrane interaction and thus homeostatic function.

    • Michelle S. Prew
    • Christina M. Camara
    • Loren D. Walensky
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12