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Showing 1–50 of 5601 results
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  • Analysis combining multiple global tree databases reveals that whether a ___location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

    • Camille S. Delavaux
    • Thomas W. Crowther
    • Daniel S. Maynard
    ResearchOpen Access
    Nature
    Volume: 621, P: 773-781
  • This study used fine-mapping to analyze genetic regions associated with bipolar disorder, identifying specific risk genes and providing new insights into the biology of the condition that may guide future research and treatment approaches.

    • Maria Koromina
    • Ashvin Ravi
    • Niamh Mullins
    ResearchOpen Access
    Nature Neuroscience
    Volume: 28, P: 1393-1403
  • Embryonal tumour with multilayered rosettes (ETMR) is a rare and aggressive paediatric brain tumour. Here, the authors analyse intratumour heterogeneity and the tumour microenvironment in ETMR using single-cell and spatial transcriptomics, in vitro cultures, and a 3D forebrain organoid model, finding important aspects – such as the communication with pericytes – for ETMR development and response to therapy.

    • Flavia W. de Faria
    • Nicole C. Riedel
    • Kornelius Kerl
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19
  • Species’ traits and environmental conditions determine the abundance of tree species across the globe. Here, the authors find that dominant tree species are taller and have softer wood compared to rare species and that these trait differences are more strongly associated with temperature than water availability.

    • Iris Hordijk
    • Lourens Poorter
    • Thomas W. Crowther
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • The epigenetic mechanisms underlying phenotypic diversity across different metastatic sites in castration-resistant prostate cancer (CRPC) remain to be characterised. Here, multi-omic profiling across metastatic lesions identifies regulatory networks driving tumour lineage programs and potential therapeutic targets.

    • Kei Mizuno
    • Sheng-Yu Ku
    • Himisha Beltran
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Proteomic data from natural isolates of Saccharomyces cerevisiae provide insight into how these cells tolerate aneuploidy (an imbalance in the number of chromosomes), and reveal differences between lab-engineered aneuploids and diverse natural yeasts.

    • Julia Muenzner
    • Pauline Trébulle
    • Markus Ralser
    ResearchOpen Access
    Nature
    Volume: 630, P: 149-157
  • The study advances the use of serological surveys to guide trachoma elimination program decisions and provides a way to set thresholds for whether or not to continue an intervention program.

    • Everlyn Kamau
    • Pearl Anne Ante-Testard
    • Benjamin F. Arnold
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • The authors demonstrate measurement, binning, and transfer of 119 photonic crystal cavities (PhCCs) in one session, forming spatially ordered arrays sorted by resonant wavelength. In-situ monitoring reveals, for the first time, dynamic plastic and elastic responses to the print process over timescales from seconds to hours.

    • Sean P. Bommer
    • Christopher Panuski
    • Michael J. Strain
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • In a post-hoc analysis of circulating tumor DNA (ctDNA) features from patients with metastatic prostate cancer treated with [177Lu]Lu–PSMA-617 or cabazitaxel in the randomized phase 2 TheraP trial, low ctDNA levels at baseline were predictive of clinical benefit from [177Lu]Lu–PSMA-617, and PTEN or ATM alterations were identified as potential biomarkers of response.

    • Edmond M. Kwan
    • Sarah W. S. Ng
    • Alison Y. Zhang
    Research
    Nature Medicine
    P: 1-15
  • The authors estimate genomic vulnerability for closely related species of rainbowfish. They find that narrow endemic species that have hybridized with a warm-adapted generalist show reduced vulnerability to climate change and that hybridization may facilitate evolutionary rescue for such species.

    • Chris J. Brauer
    • Jonathan Sandoval-Castillo
    • Luciano B. Beheregaray
    ResearchOpen Access
    Nature Climate Change
    Volume: 13, P: 282-289
  • Grayson et al. report the genomic discovery and biochemical characterization of a widely distributed gene cluster family for briarane diterpenoid biosynthesis in metazoans. This study expands our understanding of the metazoan specialized metabolism, revealing the use of biosynthetic gene clusters by octocorals.

    • Natalie E. Grayson
    • Paul D. Scesa
    • Bradley S. Moore
    Research
    Nature Chemical Biology
    P: 1-10
  • Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

    • Nora I. Strom
    • Zachary F. Gerring
    • Manuel Mattheisen
    ResearchOpen Access
    Nature Genetics
    Volume: 57, P: 1389-1401
  • Nature Biotechnology’s annual survey highlights university startups that are, among other things, rethinking how to deliver gene-editing therapy and tackling various metabolic conditions, immune disorders and cancer with microbiome treatments or immunotherapy. Michael Eisenstein, Ken Garber, Esther Landhuis, Caroline Seydel and Laura DeFrancesco report.

    • Michael Eisenstein
    • Ken Garber
    • Laura DeFrancesco
    News
    Nature Biotechnology
    Volume: 39, P: 1036-1047
  • In the Tumor Profiler proof-of-concept observational study, a multiomics approach for profiling tumors from patients with melanoma was feasible, returning data within 4 weeks and informing treatment recommendations in 75% of cases.

    • Nicola Miglino
    • Nora C. Toussaint
    • Andreas Wicki
    ResearchOpen Access
    Nature Medicine
    P: 1-12
  • A study demonstrates a public generator of random numbers based on device-independent techniques, with the randomness being fully auditable and traceable.

    • Gautam A. Kavuri
    • Jasper Palfree
    • Lynden K. Shalm
    Research
    Nature
    Volume: 642, P: 916-921
  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768
  • Sarcomas are a group of mesenchymal malignancies which are molecularly heterogeneous. Here, the authors develop an in vivo muscle electroporation system for gene delivery to generate distinct subtypes of orthotopic genetically engineered mouse models of sarcoma, as well as syngeneic allograft models with scalability for preclinical assessment of therapeutics.

    • Roland Imle
    • Daniel Blösel
    • Ana Banito
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477
  • An expert-elicitation process identifies current methodological barriers for monitoring terrestrial biodiversity, and how technological and procedural development of robotic and autonomous systems may contribute to overcoming these challenges.

    • Stephen Pringle
    • Martin Dallimer
    • Zoe G. Davies
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 9, P: 1031-1042
  • A comparison of alpha diversity (number of plant species) and dark diversity (species that are currently absent from a site despite being ecologically suitable) demonstrates the negative effects of regional-scale anthropogenic activity on plant diversity.

    • Meelis Pärtel
    • Riin Tamme
    • Martin Zobel
    ResearchOpen Access
    Nature
    Volume: 641, P: 917-924
  • Polygenic scores aim to capture genetic risk but may miss nonlinear genetic and environmental interactions. Here, the authors show that neural networks detect limited nonlinearity and do not outperform linear models, highlighting constraints in current deep-learning approaches.

    • Martin Kelemen
    • Yu Xu
    • Michael Inouye
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

    • Matthew H. Bailey
    • William U. Meyerson
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-27
  • The Nature Relationship Index offers a new way to measure and engage human aspirations to shape a better future for people and all life on Earth.

    • Erle C. Ellis
    • Yadvinder Malhi
    • Pedro Conceição
    Reviews
    Nature
    Volume: 642, P: 889-899
  • MPRAs and in vivo transgenic mouse assays are two potentially complementary ways to assay the impact of noncoding variants. Here, authors find a strong and specific correlation between the assays in neural cells. Mouse assays also reveal pleiotropic effects not observed in MPRA.

    • Michael Kosicki
    • Dianne Laboy Cintrón
    • Nadav Ahituv
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Antibiotic resistance can be addressed by reinventing classes of antibiotics through chemical synthesis. Here BT-33—a fully synthetic antibiotic—affords broad-spectrum activity against the bacterial ribosome. X-ray crystallography, theoretical calculations and structure–activity relationship studies reveal the structural features that contribute to the enhanced antibacterial activity and metabolic stability of BT-33.

    • Ben I. C. Tresco
    • Kelvin J. Y. Wu
    • Andrew G. Myers
    Research
    Nature Chemistry
    Volume: 17, P: 582-589
  • Surface structures can have an important effect on the traits of two-dimensional electron liquids. Here, the authors demonstrate how the surface terminations of SrTiO3(001) affect the mechanism and properties of the two-dimensional electron liquid.

    • Igor Sokolović
    • Eduardo B. Guedes
    • J. Hugo Dil
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • Jaegil Kim
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 94-101
  • Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

    • Moritz Gerstung
    • Clemency Jolly
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 122-128
  • Artificial intelligence (AI) system is known to improve dermatologists’ diagnostic accuracy for melanoma. This group applies the eye-tracking technology on dermatologists when diagnosing dermoscopic images of melanomas and reports improved balanced diagnostic accuracy when using an X(explainable) AI system comparing to the standard one.

    • Tirtha Chanda
    • Sarah Haggenmueller
    • Titus J. Brinker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • A population of TRAIL-positive astrocytes in glioblastoma contributes to an immunosuppressive tumour microenvironment and this mechanism can be targeted with an engineered oncolytic virus to improve outcomes.

    • Camilo Faust Akl
    • Brian M. Andersen
    • Francisco J. Quintana
    Research
    Nature
    Volume: 643, P: 219-229
  • Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

    • Céline Bellenguez
    • Fahri Küçükali
    • Jean-Charles Lambert
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 412-436
  • Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) of the salivary gland are rare tumours. Here the authors report that BCA and BCAC patients possess distinct genomic profiles despite histopathological similarities, and identify a recurrent FBXW11 missense mutation (p.F517S) which leads to accumulation of β-catenin in BCA and higher expression of Wnt/β-catenin targets.

    • Kim Wong
    • Justin A. Bishop
    • David J. Adams
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Goede et al. combined multiple modalities to define a common tremor network across disorders. This finding may help optimize deep brain stimulation and guide future noninvasive therapies.

    • Lukas L. Goede
    • Bassam Al-Fatly
    • Andreas Horn
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • In a quantum simulation of a (2+1)D lattice gauge theory using a superconducting quantum processor, the dynamics of strings reveal the transition from deconfined to confined excitations as the effective electric field is increased.

    • T. A. Cochran
    • B. Jobst
    • P. Roushan
    ResearchOpen Access
    Nature
    Volume: 642, P: 315-320
  • Some cancer patients first present with metastases where the ___location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

    • Wei Jiao
    • Gurnit Atwal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12