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Scientific Reports (26)
Hypertension Research (9)
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Showing 1–50 of 60 results

Advanced filters: Author: Michihiro Tanaka Clear advanced filters

Association between urinary sodium-to-potassium ratio and BNP in a general population without antihypertensive treatment and cardiovascular diseases: the Ohasama study

Tomoko Muroya
Michihiro Satoh
Takayoshi Ohkubo
ResearchOpen Access27 Jun 2025
Hypertension Research

P: 1-11
Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger ___domain

Kiyoji Tanaka
Naoyuki Miura
Yoshio Okada
Research01 Nov 1990
Nature

Volume: 348, P: 73-76
Oxygen-evolving photosystem II structures during S₁–S₂–S₃ transitions

Serial femtosecond crystallography reveals the structural dynamics of photosystem II during the S-state transitions that produce dioxygen, providing insight into electron transfer, water insertion, proton release and O–O bond formation on sub-microsecond timescales.

Hongjie Li
Yoshiki Nakajima
Jian-Ren Shen
ResearchOpen Access31 Jan 2024
Nature

Volume: 626, P: 670-677
Grease matrix as a versatile carrier of proteins for serial crystallography

Serial femtosecond crystallography experiments with diverse protein microcrystal suspensions are facilitated using a grease matrix as a carrier medium for sample injection.

Michihiro Sugahara
Eiichi Mizohata
So Iwata
Research10 Nov 2014
Nature Methods

Volume: 12, P: 61-63
Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography

Shifts in temperature alter the structure and dynamics of macromolecules. Now, infra-red laser-induced temperature jump is combined with X-ray crystallography to observe protein structural dynamics in real time. Using this method, motions related to the catalytic cycle of lysozyme, a model enzyme, are visualized at atomic resolution and across broad timescales.

Alexander M. Wolff
Eriko Nango
Michael C. Thompson
ResearchOpen Access18 Sept 2023
Nature Chemistry

Volume: 15, P: 1549-1558
Light-induced structural changes and the site of O=O bond formation in PSII caught by XFEL

A new approach, time-resolved serial femtosecond crystallography, is used to view the intermediate states of a photosystem complex following illumination, shedding light on proton transfer and O=O bond formation.

Michihiro Suga
Fusamichi Akita
Jian-Ren Shen
Research20 Feb 2017
Nature

Volume: 543, P: 131-135
Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme

A reduction reaction is usually equated with an electron transfer reaction. Now, ultrafast time-resolved serial femtosecond X-ray crystallography has enabled the visualization of the stepwise structural changes that occur after electron transfers have been observed in the light-triggered reduction of flavin adenine dinucleotide catalysed by DNA photolyase.

Manuel Maestre-Reyna
Cheng-Han Yang
Ming-Daw Tsai
Research07 Apr 2022
Nature Chemistry

Volume: 14, P: 677-685
Association between the duration of mothers’ digital media use while with their children and two-year-old children’s development from the Japan Environment and Children’s Study

Yuka Ogata
Takatomo Matsumoto
Takahiko Katoh
ResearchOpen Access24 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
Wnt activation disturbs cell competition and causes diffuse invasion of transformed cells through NF-κB-MMP21 pathway

The relevance of cell competition in intestinal epithelial carcinogenesis remains to be explored. Here, the authors find aberrant Wnt activation in RasV12-transformed cells reverses the directionality of cell extrusion mediated by cell competition in intestinal epithelium, causing infiltration into basal lamina rather than apical elimination of transformed cells and consequent development of invasive carcinomas.

Kazuki Nakai
Hancheng Lin
Shunsuke Kon
ResearchOpen Access03 Nov 2023
Nature Communications

Volume: 14, P: 1-17
Impact of pretransplant donor-specific anti-HLA antibodies on cord blood transplantation on behalf of the Transplant Complications Working Group of Japan Society for Hematopoietic Cell Transplantation

Shigeo Fuji
Kumi Oshima
Masao Ogata
Research07 Oct 2019
Bone Marrow Transplantation

Volume: 55, P: 722-728
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Genetic and epigenetic basis of hepatoblastoma diversity

While hepatoblastoma is the most common pediatric liver cancer, its molecular background has not been fully characterised. Here, the authors perform genomic and epigenomic profiling of 163 untreated pediatric liver tumours and suggest the upregulation of ASCL2 and methylation patterns of IGF2 promoters in driving hepatoblast carcinogenesis.

Genta Nagae
Shogo Yamamoto
Eiso Hiyama
ResearchOpen Access20 Sept 2021
Nature Communications

Volume: 12, P: 1-16
Association between maternal insecticide use and otitis media in one-year-old children in the Japan Environment and Children’s Study

Takeshi Utsunomiya
Naoko Taniguchi
Takahiko Katoh
ResearchOpen Access25 Jan 2022
Scientific Reports

Volume: 12, P: 1-8
Capsule endoscopy findings reflect the gastrointestinal conditions of patients with systemic sclerosis

Sumio Iio
Shiro Oka
Kazuaki Chayama
ResearchOpen Access11 Oct 2021
Scientific Reports

Volume: 11, P: 1-8
Prevalence of common aneuploidy in twin pregnancies

Akiko Konishi
Osamu Samura
Haruhiko Sago
ResearchOpen Access01 Jan 2022
Journal of Human Genetics

Volume: 67, P: 261-265
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Higher prevalence of hypertensive disorders of pregnancy in women who smoke: the Japan environment and children’s study

Kosuke Tanaka
Hidekazu Nishigori
Hirohito Metoki
Research21 Jan 2019
Hypertension Research

Volume: 42, P: 558-566
Day-to-day blood pressure variability is associated with lower cognitive performance among the Japanese community-dwelling oldest-old population: the SONIC study

Kayo Godai
Mai Kabayama
Yoshinobu Maeda
Research19 Dec 2019
Hypertension Research

Volume: 43, P: 404-411
Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus

Circadian rhythm is controlled by the suprachiasmatic nucleus and the mechanisms that control the rhythm are largely undiscovered. In this study, a G protein regulator, RGS16, is shown to be involved in the production of cyclic AMP that is required for the suprachiasmatic nucleus to maintain rhythm

Masao Doi
Atsushi Ishida
Hitoshi Okamura
ResearchOpen Access24 May 2011
Nature Communications

Volume: 2, P: 1-9
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

Insulin action in the brain is known to inhibit food intake. Now Leona Plum and her colleagues show that in hypothalamic neurons insulin inhibits FoxO1-mediated transcriptional repression of Cpe, a gene that encodes a carboxypeptidase that is required for proper processing of key anorexigenic neuropeptides. The team also found that this pathway is disturbed in states of diet-induced obesity, suggesting that obesity-induced insulin resistance may affect obesity even further.

Leona Plum
Hua V Lin
Domenico Accili
Research20 Sept 2009
Nature Medicine

Volume: 15, P: 1195-1201
Oil-free hyaluronic acid matrix for serial femtosecond crystallography

Michihiro Sugahara
Changyong Song
So Iwata
ResearchOpen Access18 Apr 2016
Scientific Reports

Volume: 6, P: 1-6
Depressive symptoms as risk factors for the onset of home hypertension: a prospective cohort study

Sayuri Tokioka
Naoki Nakaya
Atsushi Hozawa
ResearchOpen Access10 Jul 2024
Hypertension Research

Volume: 47, P: 2989-3000
Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate

Using photosensitive caged-compound for femtosecond crystallography at X-ray free electron lasers would allow the structure determination of reaction intermediates. Here the authors demonstrate the feasibility of this approach with a caged NO-compound and present the initial NO-bound intermediate structure of cytochrome P450 nitric oxide reductase.

Takehiko Tosha
Takashi Nomura
Minoru Kubo
ResearchOpen Access17 Nov 2017
Nature Communications

Volume: 8, P: 1-9
Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway

Circadian clock regulates hepatic gene expression and functions. Here Chao et al. show that alteration of circadian clock genes by Period deletion induces polyploidy in hepatocytes due to impaired regulation of Erk signaling by mitogen-activated protein kinase phosphatase 1.

Hsu-Wen Chao
Masao Doi
Hitoshi Okamura
ResearchOpen Access21 Dec 2017
Nature Communications

Volume: 8, P: 1-14
Secondhand smoke exposure is associated with the risk of hypertensive disorders of pregnancy: the Japan Environment and Children’s Study

The association between second-hand smoking exposure and hypertensive disorders of pregnancy risk was analyzed using the JECS data. The relative risks in 4–7 days/week and ≥2 h/day of SHS exposures were 1.18 and 1.27, respectively. The PAFs due to SHS exposure and maternal smoking were 3.80% and 1.81%, respectively.

Kosuke Tanaka
Hidekazu Nishigori
Hirohito Metoki
ResearchOpen Access03 Feb 2023
Hypertension Research

Volume: 46, P: 834-844
HOPS-R01 phase II trial evaluating neoadjuvant S-1 therapy for resectable pancreatic adenocarcinoma

Toru Nakamura
Tsuyoshi Hayashi
Akinobu Taketomi
ResearchOpen Access15 Jun 2022
Scientific Reports

Volume: 12, P: 1-9
Clinical landscape of TP73 structural variants in ATL patients

Hiroaki Hiramatsu
Rui Yokomori
Takashi Ishida
ResearchOpen Access20 Oct 2023
Leukemia

Volume: 37, P: 2502-2506
The association between depressive symptoms and masked hypertension in participants with normotension measured at research center

Depressive symptoms were associated with masked hypertension in individuals with normotension measured at research center.

Sayuri Tokioka
Naoki Nakaya
Atsushi Hozawa
ResearchOpen Access31 Oct 2023
Hypertension Research

Volume: 47, P: 586-597
Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes

Hirotake Takahashi
Tomohisa Nagoshi
Michihiro Yoshimura
ResearchOpen Access26 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
Effects of angiotensin receptor-neprilysin inhibitor on ketone body metabolism in pre-heart failure/heart failure patients

Yusuke Kashiwagi
Tomohisa Nagoshi
Michihiro Yoshimura
ResearchOpen Access17 Jul 2024
Scientific Reports

Volume: 14, P: 1-9
A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease

Shoji Seki
Yoshiharu Kawaguchi
Shiro Ikegawa
Research01 May 2005
Nature Genetics

Volume: 37, P: 607-612
Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo

Haruka Kimura
Tomohisa Nagoshi
Michihiro Yoshimura
ResearchOpen Access31 Aug 2021
Scientific Reports

Volume: 11, P: 1-11
Isoprenoid-chained lipid EROCOC₁₇₊₄: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography

Kentaro Ihara
Masakatsu Hato
Mikako Shirouzu
ResearchOpen Access09 Nov 2020
Scientific Reports

Volume: 10, P: 1-12
The thermogenic actions of natriuretic peptide in brown adipocytes: The direct measurement of the intracellular temperature using a fluorescent thermoprobe

Haruka Kimura
Tomohisa Nagoshi
Michihiro Yoshimura
ResearchOpen Access11 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Chemical transfer of dissolved organic matter from surface seawater to sea spray water-soluble organic aerosol in the marine atmosphere

Yuzo Miyazaki
Youhei Yamashita
Jun Nishioka
ResearchOpen Access05 Oct 2018
Scientific Reports

Volume: 8, P: 1-10
Enrichment of bacteria and alginate lyase genes potentially involved in brown alga degradation in the gut of marine gastropods

Michihiro Ito
Kotaro Watanabe
Haruko Takeyama
ResearchOpen Access14 Feb 2019
Scientific Reports

Volume: 9, P: 1-13
Collaborative Activities of Noradrenaline and Natriuretic Peptide for Glucose Utilization in Patients with Acute Coronary Syndrome

Goki Uno
Tomohisa Nagoshi
Michihiro Yoshimura
ResearchOpen Access24 May 2019
Scientific Reports

Volume: 9, P: 1-9
Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population

Kikuko Hotta
Michihiro Nakamura
Yusuke Nakamura
Research23 Oct 2009
Journal of Human Genetics

Volume: 54, P: 727-731
INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese

Kikuko Hotta
Michihiro Nakamura
Yusuke Nakamura
Research01 Sept 2008
Journal of Human Genetics

Volume: 53, P: 857-862
Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population

Kikuko Hotta
Michihiro Nakamura
Naoyuki Kamatani
Research12 Aug 2010
Journal of Human Genetics

Volume: 55, P: 738-742
Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis

Yoshiro Tanaka
Tomohisa Nagoshi
Michihiro Yoshimura
ResearchOpen Access30 May 2017
Scientific Reports

Volume: 7, P: 1-9
Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior

Takashi Komori
Kazuya Okamura
Manabu Makinodan
ResearchOpen Access19 Jan 2024
Molecular Psychiatry

Volume: 29, P: 1338-1349
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
In vivo recording of the circadian calcium rhythm in Prokineticin 2 neurons of the suprachiasmatic nucleus

Kaito Onodera
Yusuke Tsuno
Michihiro Mieda
ResearchOpen Access09 Oct 2023
Scientific Reports

Volume: 13, P: 1-10
Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study

Noriyuki Iwama
Mari S. Oba
Hirohito Metoki
Research10 Mar 2020
Hypertension Research

Volume: 43, P: 550-559
Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure

Hirotake Takahashi
Yusuke Kashiwagi
Michihiro Yoshimura
ResearchOpen Access08 Nov 2021
Scientific Reports

Volume: 11, P: 1-10
Mathematical-based morphological classification of skin eruptions corresponding to the pathophysiological state of chronic spontaneous urticaria

Seirin-Lee et al. develop a mathematical model to analyze the shapes of skin eruptions and link these morphological features to in vivo pathological dynamics of chronic urticaria. The proposed multidisciplinary method combining mathematical modelling, in vitro experiments, and clinical data, could constitute an innovative approach to the clinical treatment of an intractable disease.

Sungrim Seirin-Lee
Daiki Matsubara
Michihiro Hide
ResearchOpen Access04 Dec 2023
Communications Medicine

Volume: 3, P: 1-11
Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders

Yusuke Kashiwagi
Tomohisa Nagoshi
Michihiro Yoshimura
ResearchOpen Access22 Mar 2021
Scientific Reports

Volume: 11, P: 1-10
Associations of pathological diagnosis and genetic abnormalities in meningiomas with the embryological origins of the meninges

Atsushi Okano
Satoru Miyawaki
Nobuhito Saito
ResearchOpen Access26 Mar 2021
Scientific Reports

Volume: 11, P: 1-13
Delta-like 3 is silenced by HBx via histone acetylation in HBV-associated HCCs

Hiroki Hamamoto
Kentaro Maemura
Kazuhisa Uchiyama
ResearchOpen Access19 Mar 2018
Scientific Reports

Volume: 8, P: 1-11

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