Nature Search

Growing bioinformatics capacity in Africa

Continent-wide efforts to stem the tide of diseases.

Morgan Morris
Multimedia23 Aug 2023
Nature Africa
Interstellar extinction in the Large Magellanic Cloud

K. Nandy
D. H. Morgan
L. Houziaux
Research21 Feb 1980
Nature

Volume: 283, P: 725-729
Continued collaboration of ex situ and in situ programs is critical for the genetic sustainability of the endangered Rana pretiosa

Briar Hunter
Anne-Laure Ferchaud
David Lesbarrères
ResearchOpen Access22 May 2025
Scientific Reports

Volume: 15, P: 1-14
What the new cabinet means for science in South Africa

As parliament opens, and the country welcomes its first democracy-era coalition government, the director of its national science academy, Himla Soodyall, reflects on the state of research in South Africa.

Morgan Morris
Comments & Opinion18 Jul 2024
Nature Africa
Ce que le nouveau gouvernement signifie pour la science en Afrique du Sud

Alors que le parlement s'ouvre et que le pays accueille son premier gouvernement de coalition de l'ère démocratique, le directeur de l'académie nationale des sciences, Himla Soodyall, se penche sur l'état de la recherche en Afrique du Sud.

Morgan Morris
Comments & Opinion18 Jul 2024
Nature Africa
Identification of two related pentapeptides from the brain with potent opiate agonist activity

J. Hughes
T. W. Smith
H. R. Morris
Research01 Dec 1975
Nature

Volume: 258, P: 577-579
Le rôle de l’Afrique dans la deuxième révolution quantique

Andrew Forbes, professeur émérite à l’École de physique de l’université de Witwatersrand en Afrique du Sud, évoque le statut de la mécanique quantique en Afrique et au-delà.

Morgan Morris
Special Features12 Jun 2025
Nature Africa
Africa’s role in the second quantum revolution

Andrew Forbes, distinguished professor at the School of Physics at the University of the Witwatersrand in South Africa, discusses the status of quantum mechanics in Africa and beyond

Morgan Morris
Special Features12 Jun 2025
Nature Africa
Alan Christoffels: Building bioinformatics in Africa

The leader of SANBI on efforts to address skills shortages and the lack of diversity

Morgan Morris
Comments & Opinion10 Mar 2025
Nature Africa
Alan Christoffels : Le développement de la bio-informatique en Afrique

Le dirigeant de SANBI parle des efforts déployés pour remédier aux pénuries de compétences et au manque de diversité

Morgan Morris
Comments & Opinion10 Mar 2025
Nature Africa
How to measure the speed of honey bee sperm

Assessing the reproductive potential of the Cape honey bee to check population health status.

Morgan Morris
News15 Dec 2023
Nature Africa
Comment mesurer la vitesse des spermatozoïdes de l'abeille mellifère

Évaluer le potentiel reproductif de l'abeille du Cap pour vérifier l'état de santé de la population

Morgan Morris
News15 Dec 2023
Nature Africa
Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates

JEAN M. HAMBROOK
BARRY A. MORGAN
COLIN F. C. SMITH
Research26 Aug 1976
Nature

Volume: 262, P: 782-783
Signalling molecules boost plant resilience against toxic metals

Enhanced plant defence mechanisms pave the way for healthier crops.

Morgan Morris
Research Highlights17 Oct 2023
Nature Africa
Exol and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells

Alan Morgan
Robert D. Burgoyne
Research27 Feb 1992
Nature

Volume: 355, P: 833-836
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

Meningeal lymphatic drainage can affect the microglial inflammatory response and anti-amyloid-β immunotherapy in mouse models of Alzheimer’s disease.

Sandro Da Mesquita
Zachary Papadopoulos
Jonathan Kipnis
Research28 Apr 2021
Nature

Volume: 593, P: 255-260
How the SKA telescope drew me from Italy to South Africa

Astronomer Lucia Marchetti’s career took her to South Africa, where she now leads a data-visualisation lab.

Morgan Morris
Comments & Opinion02 Apr 2025
Nature Africa
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Association analyses in over 1 million individuals identify 535 new loci influencing blood pressure traits. The results provide new insights into blood pressure regulation and highlight shared genetic architecture between blood pressure and lifestyle exposures.

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1412-1425
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Des molécules de signalisation renforcent la résistance des plantes aux métaux toxiques

L'amélioration des mécanismes de défense des plantes ouvre la voie à des cultures plus saines.

Morgan Morris
Research Highlights17 Oct 2023
Nature Africa
How disease models overlook the human behaviour factor

South African mathematicians have devised a disease model that seeks to explain the gap between vaccine uptake and COVID-19 infection rates.

Morgan Morris
News01 Nov 2023
Nature Africa
COVID-19 sting could be in its tail

The envelope protein is crucial to formation of the virus envelope, and has been linked to inflammation in severe cases.

Morgan Morris
News24 Jul 2023
Nature Africa
L'aiguillon du SARS-CoV-2 (responsable du COVID-19) pourrait se trouver dans sa queue

La protéine d'enveloppe est essentielle à la formation de l'enveloppe du virus et a été associée à l'inflammation dans les cas graves.

Morgan Morris
News24 Jul 2023
Nature Africa
African scientists set genomics ‘world speed record’ in confirming Ebola outbreak in Uganda

Teams in Uganda and South Africa worked through a single weekend to confirm the strain and trace the disease’s genetic origins.

Morgan Morris
News21 Mar 2025
Nature Africa
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Comment les modèles de maladies négligent le facteur du comportement humain

Des mathématiciens sud-africains ont mis au point un modèle de maladie qui tente d'expliquer l'écart entre la vaccination et les taux d'infection par le COVID-19.

Morgan Morris
News01 Nov 2023
Nature Africa
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Leigh Holcomb
Marcia N. Gordon
Karen Duff
Research01 Jan 1998
Nature Medicine

Volume: 4, P: 97-100
Trump freezes funds and Africa counts the costs

As programmes pause, health officials and programme leaders wait for the fallout

Morgan Morris
News06 Feb 2025
Nature Africa
Crystal structure of human chorionic gonadotropin

A. J. Lapthorn
D. C. Harris
N. W. Isaacs
Research09 Jun 1994
Nature

Volume: 369, P: 455-461
The evolutionary history of 2,658 cancers

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

Moritz Gerstung
Clemency Jolly
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature

Volume: 578, P: 122-128
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Some cancer patients first present with metastases where the ___location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Wei Jiao
Gurnit Atwal
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-12
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Yulia Rubanova
Ruian Shi
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-12
Booster la recherche de composés antipaludiques

En créant un outil permettant de passer au crible de vastes bibliothèques de composés potentiels, Jessica Thibaud a bon espoir de faire bouger les choses.

Morgan Morris
Comments & Opinion10 May 2023
Nature Africa
Insect mating calls drowned out by rowdy humans

Bladder grasshoppers and other creatures are adapting their mating calls amid increasing anthropogenic cacophony.

Morgan Morris
News01 May 2023
Nature Africa
Digging deep in the search for anti-malaria compounds

Building a tool to sift through vast libraries of potential compound, Jessica Thibaud has high hopes of making a difference.

Morgan Morris
Comments & Opinion10 May 2023
Nature Africa
The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
Dynamics of anterior–posterior axis formation in the developing mouse embryo

Detailed analysis of axis development in mouse embryo has been limited. Morriset al. developed an in vitroculture technique that enables the real-time observation of an anterior visceral endoderm formation and show that cell marker asymmetry within the AVE subdomain dictates the direction of the AVE migration.

Samantha A. Morris
Seema Grewal
Magdalena Zernicka-Goetz
ResearchOpen Access14 Feb 2012
Nature Communications

Volume: 3, P: 1-10
Functional magnetic resonance imaging of synesthesia: activation of V4/V8 by spoken words

J. A. Nunn
L. J. Gregory
J. A. Gray
Research25 Feb 2002
Nature Neuroscience

Volume: 5, P: 371-375
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Comment le télescope SKA m'a attirée de l'Italie vers l'Afrique du Sud

La carrière de l'astronome Lucia Marchetti l'a conduite en Afrique du Sud, où elle dirige aujourd'hui un laboratoire de visualisation de données.

Morgan Morris
Comments & Opinion02 Apr 2025
Nature Africa
Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture

Whole-genome sequence analysis identifies five independent risk loci for Lewy body dementia and demonstrates overlapping genetic architecture with Alzheimer’s and Parkinson’s diseases.

Ruth Chia
Marya S. Sabir
Sonja W. Scholz
Research15 Feb 2021
Nature Genetics

Volume: 53, P: 294-303
Study identifies genes linked to high prostate cancer mortality rates

Researchers shed light on the genes that could be linked to the high mortality rates of prostate cancer among men of African descent.

Morgan Morris
Research Highlights06 Jan 2025
Nature Africa
Une étude identifie les gènes liés aux taux élevés de mortalité par cancer de la prostate

Des chercheurs ont mis en lumière les gènes qui pourraient être liés aux taux de mortalité élevés du cancer de la prostate chez les hommes d'origine africaine.

Morgan Morris
Research Highlights06 Jan 2025
Nature Africa
Animal Intelligence

MORGAN J. ROBERTS
Research06 Sept 1883
Nature

Volume: 28, P: 436-437
Inferring structural variant cancer cell fraction

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Marek Cmero
Ke Yuan
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-15
Des scientifiques africains établissent un « record de vitesse » en génomique en confirmant l'existence de l'épidémie d'Ebola en Ouganda

Des équipes d'Ouganda et d'Afrique du Sud ont travaillé pendant un seul week-end pour confirmer la souche et retracer les origines génétiques de la maladie.

Morgan Morris
News21 Mar 2025
Nature Africa

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