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Scientific Reports (45)
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Showing 1–50 of 88 results

Advanced filters: Author: Morio Nakamura Clear advanced filters

How many cases of spinal intramedullary ependymoma surgery are required to achieve stability? - Analysis using X-bar charts

Narihito Nagoshi
Kengo Nagashima
Kota Watanabe
Research21 May 2025
Spinal Cord

P: 1-5
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Longitudinal MRI study over 20 years of cervical posterior extensor muscle area in asymptomatic subjects

Hiroyuki Izumida
Kenshi Daimon
Kota Watanabe
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Surgical outcomes of cervical spinal cord tumor in elderly patients assessed by the Japanese Orthopedic Association Cervical Myelopathy Evaluation Questionnaire

Shuhei Ito
Narihito Nagoshi
Kota Watanabe
Research22 Mar 2025
Spinal Cord

Volume: 63, P: 239-245
Drastic genetic instability of tumors and normal tissues in Turcot syndrome

Michiko Miyaki
Junko Nishio
Joji Utsunomiya
Research04 Dec 1997
Oncogene

Volume: 15, P: 2877-2881
Epidemiology and surgical outcomes of pediatric intradural spinal tumors: results from a retrospective series of patients operated in the first two decades of life

Narihito Nagoshi
Toshiki Okubo
Kota Watanabe
Research13 Dec 2024
Spinal Cord

Volume: 63, P: 75-79
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Clinical application of diffusion tensor tractography to postoperative C5 palsy

Morito Takano
Osahiko Tsuji
Kota Watanabe
Research22 Sept 2021
Spinal Cord Series and Cases

Volume: 7, P: 1-5
The patient demographics, radiographic index and surgical invasiveness for mechanical failure (PRISM) model established for adult spinal deformity surgery

Mitsuru Yagi
Naobumi Hosogane
Kota Watanabe
ResearchOpen Access09 Jun 2020
Scientific Reports

Volume: 10, P: 1-10
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis

Iga et al. perform single-cell RNA sequencing and identify a distinct bone marrow endothelial cell subtype that contributes to the acquisition of bone strength and offers a distinct haematopoietic stem cell niche.

Takahito Iga
Hiroshi Kobayashi
Yoshiaki Kubota
ResearchOpen Access05 Oct 2023
Nature Cell Biology

Volume: 25, P: 1415-1425
Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese

Adolescent idiopathic scoliosis (AIS) is a common pediatric disease leading to spinal deformities. Here, the authors report GWAS followed by genome-wide meta-analysis in up to 79,211 Japanese individuals, identifying 20 genetic loci for AIS, 14 of which were previously unreported, and perform in vitro validation for rs1978060.

Ikuyo Kou
Nao Otomo
Shiro Ikegawa
ResearchOpen Access15 Aug 2019
Nature Communications

Volume: 10, P: 1-9
A serum microRNA classifier for the diagnosis of sarcomas of various histological subtypes

Sarcomas are rare malignant tumours of bone and soft tissue whose diagnosis remain difficult. Here, the authors analyse serum samples from over 1000 patients and using separate discovery, training and validation cohorts, identify and validate a 7-microRNA index that distinguishes malignant sarcomas from benign disease.

Naofumi Asano
Juntaro Matsuzaki
Takahiro Ochiya
ResearchOpen Access21 Mar 2019
Nature Communications

Volume: 10, P: 1-10
Platelet like cells differentiated from human adipose derived mesenchymal stem cells promote healing of tendinopathy in rats

Yuichi Yamada
Akiko Torii
Takeshi Miyamoto
ResearchOpen Access29 Apr 2025
Scientific Reports

Volume: 15, P: 1-10
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Natural history and surgical outcomes of idiopathic spinal cord herniation

Yuichiro Hirose
Narihito Nagoshi
Kota Watanabe
Research28 Jun 2023
Spinal Cord

Volume: 61, P: 441-446
Validation of a surgical drill with a haptic interface in spine surgery

Kento Yamanouchi
Shunya Takano
Mitsuru Yagi
ResearchOpen Access12 Jan 2023
Scientific Reports

Volume: 13, P: 1-11
Comparison of surgical outcomes of posterior surgeries between cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament

Satoshi Nori
Narihito Nagoshi
Junichi Yamane
Research31 Aug 2022
Spinal Cord

Volume: 60, P: 928-933
Changes in cross-sectional areas of posterior extensor muscles in thoracic spine: a 10-year longitudinal MRI study

Hitoshi Umezawa
Kenshi Daimon
Kota Watanabe
ResearchOpen Access30 Aug 2022
Scientific Reports

Volume: 12, P: 1-8
Serum C-reactive protein is an early, simple and inexpensive prognostic marker for the progression of intramedullary lesion on magnetic resonance imaging from acute to subacute stage in patients with spinal cord injury

Masahiro Ozaki
Kota Suda
Norimasa Iwasaki
Research27 May 2021
Spinal Cord

Volume: 59, P: 1155-1161
Smoking cessation increases levels of osteocalcin and uncarboxylated osteocalcin in human sera

Yasuhiro Kiyota
Hiroyasu Muramatsu
Takeshi Miyamoto
ResearchOpen Access08 Oct 2020
Scientific Reports

Volume: 10, P: 1-9
Neurological improvement is associated with neck pain attenuation after surgery for cervical ossification of the posterior longitudinal ligament

Masao Koda
Toshitaka Yoshii
Masashi Yamazaki
ResearchOpen Access07 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Clinical outcomes and a therapeutic indication of intramedullary spinal cord astrocytoma

Narihito Nagoshi
Osahiko Tsuji
Kota Watanabe
Research26 Jul 2021
Spinal Cord

Volume: 60, P: 216-222
Baseline severity of myelopathy predicts neurological outcomes after posterior decompression surgery for cervical spondylotic myelopathy: a retrospective study

Satoshi Nori
Narihito Nagoshi
Junichi Yamane
Research25 Jan 2021
Spinal Cord

Volume: 59, P: 547-553
Clinical outcomes of late decompression surgery following cervical spinal cord injury with pre-existing cord compression

Tsunehiko Konomi
Akimasa Yasuda
Takashi Asazuma
Research19 Dec 2017
Spinal Cord

Volume: 56, P: 366-371
Changes in sagittal alignment after surgical excision of thoracic spinal cord tumors in adults

Yoshiomi Kobayashi
Soya Kawabata
Narihito Nagoshi
Research08 Jan 2019
Spinal Cord

Volume: 57, P: 380-387
Clinical indicators of surgical outcomes after cervical single open-door laminoplasty assessed by the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire

Narihito Nagoshi
Osahiko Tsuji
Kota Watanabe
Research21 Feb 2019
Spinal Cord

Volume: 57, P: 644-651
Gait ability required to achieve therapeutic effect in gait and balance function with the voluntary driven exoskeleton in patients with chronic spinal cord injury: a clinical study

Hiroki Okawara
Tomonori Sawada
Masaya Nakamura
Research12 Dec 2019
Spinal Cord

Volume: 58, P: 520-527
Characteristic cerebral structural changes identified using voxel-based morphometry in patients with post-surgical chronic myelopathic pain

Yosuke Horiuchi
Osahiko Tsuji
Masaya Nakamura
Research04 Dec 2019
Spinal Cord

Volume: 58, P: 467-475
Assessing cortical plasticity after spinal cord injury by using resting-state functional magnetic resonance imaging in awake adult mice

Kohei Matsubayashi
Narihito Nagoshi
Masaya Nakamura
ResearchOpen Access26 Sept 2018
Scientific Reports

Volume: 8, P: 1-8
The effect of posterior tethers on the biomechanics of proximal junctional kyphosis: The whole human finite element model analysis

Mitsuru Yagi
Yuko Nakahira
Masami Iwamoto
ResearchOpen Access26 Feb 2020
Scientific Reports

Volume: 10, P: 1-8
Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice

Hideyuki Shirasawa
Noboru Matsumura
Keisuke Horiuchi
ResearchOpen Access31 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Concurrent dorsal subpial schwannoma and ventral meningioma arising at the same upper cervical level: a case report

Yu Suematsu
Osahiko Tsuji
Morio Matsumoto
Research15 Jul 2020
Spinal Cord Series and Cases

Volume: 6, P: 1-6
The significance of cerebrospinal fluid dynamics in adolescent idiopathic scoliosis using time-SLIP MRI

Yusuke Tomita
Mitsuru Yagi
Masaya Nakamura
ResearchOpen Access28 May 2024
Scientific Reports

Volume: 14, P: 1-10
Generation of heterozygous fibrillin-1 mutant cloned pigs from genome-edited foetal fibroblasts

Kazuhiro Umeyama
Kota Watanabe
Morio Matsumoto
ResearchOpen Access14 Apr 2016
Scientific Reports

Volume: 6, P: 1-10
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

On 11 June 2009 the World Health Organization declared that the infections caused by a new strain of influenza A virus closely related to swine viruses had reached pandemic levels. Here, one of the first US isolates of the new swine-origin H1N1 influenza virus (S-OIV) is characterized, as well as several other S-OIV isolates, both in vitro and in vivo.

Yasushi Itoh
Kyoko Shinya
Yoshihiro Kawaoka
Research13 Jul 2009
Nature

Volume: 460, P: 1021-1025
An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis

Yoji Ogura
Kazuki Takeda
Shiro Ikegawa
ResearchOpen Access16 Mar 2018
Scientific Reports

Volume: 8, P: 1-7
Bezafibrate attenuates immobilization-induced muscle atrophy in mice

Satoshi Nakamura
Yuiko Sato
Takeshi Miyamoto
ResearchOpen Access26 Jan 2024
Scientific Reports

Volume: 14, P: 1-9
Does the presence or absence of preoperative lower extremity neurologic symptoms influence postoperative clinical outcome in patients with cervical intradural extramedullary tumors?: a single-center retrospective comparative study

Toshiki Okubo
Narihito Nagoshi
Kota Watanabe
Research09 Oct 2024
Spinal Cord

Volume: 63, P: 9-15
Does the presence of preoperative neck pain impact clinical outcomes after posterior decompression in patients with cervical ossification of the posterior longitudinal ligament?: Retrospective multicenter cohort study

Toshiki Okubo
Narihito Nagoshi
Junichi Yamane
Research05 Sept 2024
Spinal Cord

Volume: 62, P: 619-624
Recurrence of cervical intramedullary gliofibroma

Keita Tokunaga
Narihito Nagoshi
Morio Matsumoto
Research05 Nov 2021
Spinal Cord Series and Cases

Volume: 7, P: 1-6
Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice

Satoshi Nakamura
Yuiko Sato
Takeshi Miyamoto
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-12
Cervical intramedullary recurrent Ewing sarcoma after 10-year disease-free survival in an adult: a case report and review of literature

Keita Fukushima
Osahiko Tsuji
Morio Matsumoto
Research27 May 2021
Spinal Cord Series and Cases

Volume: 7, P: 1-7
Grade III intradural extramedullary anaplastic ependymoma managed with near-complete resection and adjuvant radiotherapy: a case report

Satoshi Ando
Osahiko Tsuji
Morio Matsumoto
Research19 Jan 2021
Spinal Cord Series and Cases

Volume: 7, P: 1-6
Surgical resection of arteriovenous fistula at the cauda equina

Toshiyuki Shimizu
Narihito Nagoshi
Morio Matsumoto
Research13 Apr 2021
Spinal Cord Series and Cases

Volume: 7, P: 1-4
IL-6, IL-17 and Stat3 are required for auto-inflammatory syndrome development in mouse

Takatsugu Oike
Hiroya Kanagawa
Takeshi Miyamoto
ResearchOpen Access25 Oct 2018
Scientific Reports

Volume: 8, P: 1-11
Oral administration of N-acetyl cysteine prevents osteoarthritis development and progression in a rat model

Yosuke Kaneko
Nobuharu Tanigawa
Takeshi Miyamoto
ResearchOpen Access10 Dec 2019
Scientific Reports

Volume: 9, P: 1-11
Multifocal primary melanoma of the cervical spinal cord successfully treated by tumorectomy: a case report

Takahito Iga
Akio Iwanami
Morio Matsumoto
Research21 Mar 2018
Spinal Cord Series and Cases

Volume: 4, P: 1-4

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