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Methods for constructing targeted synthetic communities using existing microbial resources remain limited. Here, the authors report a genome-scale metabolic model-integrated strategy for bottom-up construction of synthetic microbial communities in the plant rhizosphere.

Combining antibody drug conjugates (ADCs) and tyrosine kinase inhibitors (TKIs) targeting HER2 has been shown to improve efficacy in patients with advanced HER2+ breast cancer. Here, the authors report a randomised phase 2b trial comparing neoadjuvant ARX788 (HER2 ADC) plus pyrotinib (HER1, HER2 and HER4 TKI) against neoadjuvant standard of care (docetaxel, carboplatin, trastuzumab, and pertuzumab) for the treatment of HER2+ breast cancer.

An 8-year field experiment explores optimal biochar application strategies for reducing carbon dioxide emissions and boosting economic gains from rice production.

This study introduces a concept of persistent disruption, which marks papers that disrupt previous work but remain undisrupted later, signaling lasting impact. Milestone papers are found to be consistently associated with persistent disruption.

The Colorado potato beetle, a major pest of potato crops, displays conspicuous coloration to advertise their toxicity to predators, but the identity of the toxic compounds is unclear. Here, Kang et al. show that the insect releases toxic hydrogen cyanide, which results from the degradation of cyano-compounds produced by commensal bacteria.

Genomic studies often lack representation from diverse populations, limiting equitable insights. Here, the authors show that the BIG Initiative captures extensive genetic diversity and reveals ancestry-linked health disparities in a community-based Mid-South cohort.

An endohedral metallofullerene–polymer layer, which features ultrafast electron extraction and in situ encapsulation, improves the efficiency and stability of perovskite solar cells.

Long-lived room temperature phosphorescence (LRTP) is important in organic photonics but exploring a universal approach to obtain LRTP in amorphous polymers is challenging. Here the authors present a facile chemical strategy to achieve ultralong phosphorescence in polymers by ionic bonding cross-linking.

Authors propose an entropy engineering strategy to realize the carrier-phonon decoupling in SrTiO₃-based perovskite thermoelectrics, reducing the lattice thermal conductivity nearly to the amorphous limit and improving the weighted mobility.

Lead halide perovskite lasers have great potential as microscale organic light sources, but dynamic tuning has yet to be achieved. Here, Zhang, Fan et al. investigate how nonlinear modal interactions enable ultrafast mode switching with crossgain saturation.

Information on how oxygen ions transport is crucial to understanding field-induced phase transformations in materials. Here, Zhang et al. directly image atomic-scale oxygen migration and the subsequent structural reconstruction in a SrCoO_2.5-σ film in the presence of an electric field.

Limited whole genome sequencing (WGS) of Asian populations results in a lack of representative reference panels, hindering imputation of Asian ancestry-specific genetic variants. Here the authors use WGS data from 11,067 individuals across 17 Asian countries to create a new reference panel which shows improved imputation accuracy for South Asian populations.

Schizophrenia is a severe psychiatric disorder and the pathogenesis remains unclear. Here, the authors show a potential role for synaptotagmin-11 in schizophrenia-related behavior through dopamine over-transmission.

Yang et al. show an age-related increase in the microbial-derived metabolite phenylacetylglutamine that drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via ADR–AMPK signaling.

Li et al. perform a phase 2 single-arm clinical trial of neoadjuvant chemotherapy plus checkpoint blockade in participants with resectable muscle-invasive bladder cancer and conduct genomic and transcriptomic profiling to describe molecular subtypes.

The authors demonstrate voltage-controlled multiferroic magnon torque in BiFeO₃ heterostructures, enabling reconfigurable logic-in-memory devices. This work highlights potential for low-power, scalable magnonics in room-temperature computing.

Macrophages are considered a good candidate for cancer cytotherapy because of their phagocytotic capacity, enabling them to deliver cargo to tissues. Here authors engineer macrophages that are targeted to glypican-3-expressing tumour cells and equipped with drug-loaded exosomes and show therapeutic efficiency in a mouse model of hepatocellular cancer.

Rapid detection of antiviral resistant strains is important for effective clinical treatment. Here the authors develop an antibody which specifically binds to multidrug-resistant influenza virus and demonstrated detection in a number of different systems using the antibody.

Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

Polar Solomon rings in a ferroelectric nanocrystal have been observed and electrically manipulated, which consist of two intertwined vortices and are mathematically equivalent to a \({4}_{1}^{2}\) link in topology based on knots and links theory.

This study identifies a positive-feedback loop between the ACC and the VTA that mediates the mutual exacerbation between hyperalgesia and comorbid anxiodepressive-like behaviors and, thereby, the chronicity of neuropathic pain.

Ensembles of fear and extinction memories compete and interact to drive opposing behaviors. Here the authors identified insular cortical circuits as an executive gateway that decipher between fear and extinction memories via distinct subcortical pathways.

High-quality genomes of two cultivated tetraploid cottons Gossypium hirsutum cv. NDM8 and Gossypium barbadense acc. Pima90 and resequencing of 1,081 G. hirsutum accessions provide insights into the role of structural variations.

Variants in the FTO gene locus are known to be associated with obesity, including rs1421085 T>C variant, and now it is shown in mouse knock-in models that this C-allele increases expression of the Fto gene in brown adipocytes and enhances brown adipose tissue thermogenesis and obesity resistance.

Unlike Panax species, which can produce dammarane-type saponins, Aralia elata can only synthesize oleananetype saponins. Here, the authors reveal that the loss of the dammaranediol synthase-encoding gene and tandem duplication of triterpene biosynthetic genes drive structural divergences of saponins between the two genera.

Switchable structural and physical bistability in ferroelectric materials can be achieved as result of molecular orbital breaking. Here, the authors describe the photo-mediated bistability in organosilicon Schiff base ferroelectric crystals for the modulation of dielectric, second-harmonic generation, and ferroelectric polarization and showing good in vitro biocompatibility.

Using exome sequencing data from one of the largest cohorts of children with cerebral palsy, the genetic diagnostic rates of single-nucleotide and copy number variants were assessed and a sizeable fraction found to be clinically actionable.

The nexine is a conserved layer of the pollen wall in land plants. The authors show that the AHL family protein TRANSPOSABLE ELEMENT SILENCING VIA AT-HOOK (TEK) is necessary for nexine formation in Arabidopsis, acting downstream of the transcription factor ABORTED MICROSPORES (AMS).

Neoadjuvant therapy is recommended for patients with locally advanced breast cancer. Here the authors report the results of a phase 2 clinical trial of oral neoadjuvant therapy with pyrotinib (pan-HER tyrosine kinase inhibitor), letrozole (aromatase inhibitor) and dalpiciclib (CDK4/6 inhibitor) in patients with treatment-naïve and stage II-III triple positive breast cancer.

Electric modulation of second harmonic generation finds applications in integrated photonics. Here, authors introduce electric field-induced second harmonic generation by polar skyrmions in PbTiO₃/SrTiO₃ superlattices with giant modulation depth.

The nuclear lamina in Arabidopsis, a protein meshwork beneath the nuclear envelope, disassembles under various abiotic stresses, modulating changes in three-dimensional genome organization and gene transcription in stress response.