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Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Systematic analysis from the Global Burden of Disease study reported that, despite global improvements from 1990 to 2021, dietary iron deficiency-associated disease burden remains high in women, children and residents in low socio-demographic index countries.

Quantum emitters have recently been identified as efficient sources of graph states, which are entangled states crucial for photonic quantum computation. Here the authors demonstrate deterministic and reconfigurable generation of caterpillar graph states using a semiconductor quantum dot in a cavity.

Metformin may serve as a non-toxic intervention to inhibit mitochondrial metabolism and slow DNMT3A-R882 clonal haematopoiesis expansion, thus delaying or averting progression to acute myeloid leukaemia.

GABA is an important neurotransmitter in animals, and while it accumulates in plants under stress, its potential role in plant signalling was poorly understood. Here, Rameshet al. show that GABA rapidly alters the activity of plant ALMT anion channels modifying root growth and stress tolerance.

In this work, the authors probe the efficacy of BWC0977, a bacterial topoisomerase inhibitor, in pre-clinical animal models, also demonstrating that BWC0977 is safe and well tolerated in healthy human volunteers, in a phase 1 trial.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

The molecular characteristics of myocarditis associated with immune checkpoint inhibitors are described and potential biomarkers of onset and severity are identified.

Complex oxide interfaces are important for electronic and spintronic applications. In this study, the authors show the emergence of spontaneous magnetism at one such interface between two phases of BiFeO₃due to strain effects and piezoelectric coupling.

Crystal symmetries play an important role in the properties of materials, but allow little dynamic control once the materials have been grown. Here, the authors show that conducting oxides sandwiched between independently switchable ferroelectric films achieve tunable symmetry for controllable properties.

Electrochromic materials reversibly change their colour upon application of an electric field. Seidelet al. measure the optical properties of doped bismuth ferrite and report the largest electrochromic response for an inorganic material, which they attribute to the melting of oxygen-vacancy ordering.

Defaunation is linked to the decline of tree species that depend on large animals for seed dispersal, but it is unclear if this affects carbon storage. Here the authors show that defaunation effects on carbon storage vary across continents, driven by relationships between seed dispersal strategies and adult tree size.

Steps in the electrostatic potential at ___domain walls in a ferroelectric material give rise to a new kind of photovoltaic effect that produces voltages significantly higher than the bandgap of the material.

The control of magnetization by electric fields is important for applications in data storage and sensing. An efficient control of exchange bias by electric fields has now been achieved in thin-film devices in which a ferroelectric antiferromagnet is coupled to a ferromagnet.

Ferroelectric domains in multiferroic materials can be engineered through the lateral motion of a biased scanning probe tip.

Domain walls may be important in future electronic devices, given their small size as well as the fact that their ___location can be controlled. In the case of insulating multiferroic oxides, ___domain walls are now discovered to be electrically conductive, suggesting their possible use in logic and memory applications.

Previous understanding of the coupling between ferroelectric structure and magnetic texture in BiFeO₃ has relied on mesoscale measurements. Here, the authors image coupling directly, showing a complex spin cycloid controlled with electric field.

Here, authors study boulders’ fractures on S-type asteroid, Dimorphos, and show that their size-frequency distribution and orientation are consistent with formation through thermal fatigue. Such fractures seem to propagate horizontally much faster (~kyr) than normal to the boulder’s surface (~Myr).

The polar chiral texture of the vortex or skyrmion structure in ferroelectric oxide PbTiO₃/SrTiO₃ superlattice attracts attention. Here, the authors report a theoretical framework to probe emergent chirality of electrical polarization textures.

The mechanism underlying endothelial cell responses to BMP signals is unknown. Here, the authors show that the endothelial response to pro-angiogenic BMP ligands is regulated by Notch via its effect on SMAD6, a known inhibitor of BMP intracellular signaling cascade.

Kolibius et al. show that individual neurons in the human hippocampus code for particular episodic memories.

The large intestine mucosa possesses a surprising plasticity to switch on small intestine genes. Here, Wei G. et al. show that a chromatin complex composed of SATB2, MTA2 and HNF4A regulates this tissue plasticity in the adult gut.

Tuberculous meningitis is difficult to differentiate from meningitis caused by other pathogens. Here, the authors combine metagenomics-based pathogen detection in cerebrospinal fluid with a host gene expression-based machine learning classifier for diagnosis.

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

In a prospective study, a team-based approach combining continuous glucose monitoring with a technology-assisted remote patient monitoring program improved glycemia in a diverse cohort of children, adolescents and young adults with newly diagnosed type 1 diabetes.

Using experiments in organoids and in vivo in mice, the authors show that Apc-mutant cells act as supercompetitors to initiate the formation of adenomas.

Remotely sensed NDVI data and contemporary field data from 84 grasslands on 6 continents show increasing divergence in aboveground plant biomass between sites in different bioclimatic regions.