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Nature Immunology (1)

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Aberrant T follicular helper cells generated by T_H17 cell plasticity in the gut promote extraintestinal autoimmunity

Wu and colleagues show that T_H17 cells arising in the gut in response to segmented filamentous bacteria can convert to highly mobile follicular helper T_FH17 cells, emigrate to the spleen and regulate auto-antibody production and arthritis severity.

Tingting Fan
Chi Tai
Hsin-Jung Joyce Wu
Research30 Apr 2025
Nature Immunology

Volume: 26, P: 790-804

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Aberrant T follicular helper cells generated by TH17 cell plasticity in the gut promote extraintestinal autoimmunity

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Aberrant T follicular helper cells generated by T_H17 cell plasticity in the gut promote extraintestinal autoimmunity