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In a magnetoelectric material, an applied electric field can drive changes in the magnetic order. This feature has profound technology prospects and here, Moody et al demonstrate deterministic control of the direction of magnetic spiral order via an applied electric field in Cu₂OSeO₃.

Sensitive diagnostics are needed to detect carcinogenic human liver fluke infections. Sadaow et al. here use an immunomics approach to develop field-deployable tests for diagnosing liver fluke infection and its associated liver cancer.

The authors report an ultra-broadband ptychography method, suitable for dispersive samples, by exploiting structured illumination and a novel joint deconvolution algorithm.

Fluorescent calcium imaging reveals the firing patterns of brain cells, but microscopy in behaving animals is challenging due to brain motion. Here, the authors develop a two-photon fluorescent microscope to record from many cells in a brain volume of freely-behaving Drosophila larvae.

A 90-year sea level record (1930-2019) is constructed from the growth of a tropical coral and reveals a marked acceleration in sea-level rise in the central Indian Ocean beginning in 1959 (3.44 ± 0.68 mm.y-1), much earlier than previously thought.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

An analysis of research papers and citing patents indicates the extensive ties between computer-vision research and surveillance.

Tracking raw materials is critical for securing global supply chains, but traditional tags lack in traceability and anticounterfeiting. The authors present a DNATag-based system for secure traceability, featuring error tolerance, mobile phone readability, and robust forgery protection.

Membrane protein ComM transiently inhibits cell division during competence development in Streptococcus pneumoniae through unclear mechanisms. Here, Juillot et al. show that ComM interacts with a putative activator of the septal peptidoglycan synthetic complex FtsW:PBP2x, leading to a reduction of speed of septal peptidoglycan synthesis during competence.

Using 1,425 UK Biobank participants, we show for the first time that morphological brain asymmetry exhibits evidence of plasticity changes throughout adulthood, which tracks individual variation ~1,000 lifestyle factors and ~4,500 disease ICD codes.

The authors conduct a national inventory on individual tree carbon stocks in Rwanda using aerial imagery and deep learning. Most mapped trees are located in farmlands; new methods allow partitioning to any landscape categories, effective planning and optimization of carbon sequestration and the economic benefits of trees.

In the canonical model of auditory processing, thalamocortical inputs to the primary auditory cortex initiate a hierarchical transmission to higher-order cortices. Here, authors reveal alternative auditory pathways that bypass the primary auditory cortex and directly activate higher-order cortex within <10 ms in mice, enabling parallel and distributed processing of fast sensory information across cortical areas.

Cascadia is a mass spectrometry-based de novo sequencing model that uses a transformer architecture to handle data-independent acquisition data and achieves substantially improved performance across a range of instruments and experimental protocols.

Food-grade titanium dioxide (fgTiO₂) is a biopersistent particle, but neither the target cells nor the risks of fgTiO₂ are well understood. Here, the authors identify immunocompetent cell targets of fgTiO₂ in humans, most notably in the subepithelial dome region of intestinal Peyer’s patches, and demonstrate a mouse model allowing human-relevant risk assessments of ingested, bio-persistent (nano)particles.

Nanotwinned ceramic chromium nitride (NT-CrN) is prepared by precisely controlling the deposition ion energy, which demonstrates high hardness (>36 GPa) with room-temperature compressive plasticity exceeding 40% without brittle fracture.

This study shows that brain connectivity changes in Huntington’s disease begin decades before symptoms, shifting from hyper- to hypoconnectivity, with links to specific neurotransmitter systems specially in granular and infragranular cortical layers.

A platform based on quantum-emitter-embedded metasurfaces with a microcavity that can be tuned by a micro-electromechanical system is demonstrated, enabling dynamic photon emission with narrow bandwidth, ångström-level wavelength tunability and polarization switching.

Quantum spin-ice phases are predicted to have emergent gauge fields and fractionalization. Neutron scattering and thermodynamic measurements of the quantum spin-ice candidate Ce₂Zr₂O₇ show features consistent with these predictions.

Species synchrony is considered a major mechanism of biodiversity–ecosystem stability relationships. Here, by combining theory, modelling and empirical work, the authors show that with time series length species synchrony decreases and its relationship with diversity switches from positive to negative.

Here, the authors introduce carbon-to-carbon metal migration as a platform for dynamic association and show how such migrations, in combination with the incorporation of a simple hydrocarbon, can be harnessed to achieve autonomous directional translational motion of a metal centre along the length of a polyaromatic thread.

A long-lived photoinduced metastable state in a quasi-one-dimensional cuprate, Sr₁₄Cu₂₄O₄₁, is reported.

A sunlight-activated chemical spray increases wheat yield in field trials across rainfall conditions.

Kidney transplants are at risk of graft failure due to immune system rejection. Here, the authors assess a broad range of clinical and immunological baseline variables in a large, unselected kidney transplant cohort, providing further insights into factors associated with antibody-mediated rejection

A soft mesh microelectrode array can seamlessly integrate in developing brains, enabling long-term, stable mapping of how single-neuron activity and population dynamics emerge and evolve during brain development.

An adaptive deep brain stimulation algorithm delivers targeted stimulation increases during movement using brain motor signals.

The collapse of tropical forests during the Permian–Triassic Mass Extinction weakened carbon sequestration, sustaining high CO2 and extreme global warmth for millions of years: an example of a runaway feedback in Earth’s climate-carbon system.

In this cross-sectional study, the authors used structural MRI to compare subcortical volumes, cortical thickness and surface area between early-onset anorexia nervosa, avoidant/restrictive food intake disorder and typically developing young individuals.

Bacterial attachment on implanted medical devices depends on surface topography. Here, the authors screen combinatorially generated shapes embossed into polymers to investigate topographical control of bacterial responses to surfaces.

Chemist who launched the study of caged hydrocarbons.

Analysis combining multiple global tree databases reveals that whether a ___location is invaded by non-native tree species depends on anthropogenic factors, but the severity of the invasion depends on the native species diversity.

The arcuate fascicle connection with the middle temporal gyrus has been considered unique to humans. Using high-resolution diffusion MRI, the authors systematically show this connection in chimpanzees, suggesting a gradual evolution of the language network.

No approved vaccines are available against Marburg virus. In this study, the authors developed mRNA vaccines against Marburg virus and the related Ravn virus and show that they induce robust antibody response and provide protection against homologous and heterologous viruses in guinea pigs.

The validation of inhibitors targeting PurF, a novel drug target for tuberculosis drug discovery, is described.

A theoretical foundation for entrapment methods is presented, along with a method that enables more accurate evaluation of false discovery rate (FDR) control in proteomics mass spectrometry analysis pipelines. Evaluation of popular data-dependent acquisition tools indicates that these generally seem to control the FDR, but data-independent acquisition tools exhibit inconsistent control of the FDR at both the peptide and protein levels.

The systemic discovery of metal–small-molecule complexes from biological samples is a difficult challenge. Now, a method based on liquid chromatography and native electrospray ionization mass spectrometry has been developed. The approach uses post-column pH adjustment and metal infusion combined with ion identity molecular networking, and a rule-based informatics workflow, to interrogate small-molecule–metal binding.

Material selection has a crucial role in enhancing the functionality of medical microrobots. This Review highlights the synergy between contrast and responsive materials for real-time imaging and actuation in minimally invasive medical treatments.

The microbiomes associated with reef corals are complex and diverse. Here, the authors investigate fire coral clones naturally occurring in distinct habitats as a model system to disentangle the contribution of host genotype and environment on their microbiome, and predict genomic functions based on taxonomic profiles.

Molecular complexes can function as spin qubits, and like other qubit architectures, making molecular spin qubits more resilient against interactions is vital for their use. Here, Huang et al present a molecular complex consisting of iron phthalocyanine, and an adjacent Fe atom, which together form a mixed-spin (1/2,1) quantum ferrimagnet, with improved spin lifetimes.

A combination of metagenomic data from experimental and natural warming with microbial culturing experiments shows that warming increases the potential of evolution of antibiotic resistance in soil bacteria.

The field of regenerative medicine would greatly benefit from the study of a non-human primate model. Here, the authors prospectively isolated two quiescent stem cell populations from the non-human primate mouse lemur.

A wearable device measures parenchymal resistance and its dynamic relationship with sleep MRI measures of glymphatic function, EEG features and cardiovascular parameters in humans.

Arrays of silicon nanoneedles are used to generate molecular replicas of live brain tissue for longitudinal spatial lipidomic classification via desorption electrospray ionization mass spectrometry imaging of gliomas and to monitor the responses of the tumours to chemotherapy.

The milli-spinner thrombectomy facilitates fast, complete clot removal by using spinning-induced compression and shear forces to mechanically modify the clot microstructure through densifying the fibrin network and releasing red blood cells, thus reducing clot volume.

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Noel et al. show aberrant updating of expectations in three distinct mouse models of autism spectrum disorder. Brain-wide neurophysiology data suggest this stems from excess units encoding deviations from prior mean and a lack of sensory prediction errors in frontal areas.

The mechanism of superconductivity in layered kagome metals remains unclear, however its coexistence with charge order suggests exotic interpretations. Here the authors study the vortex lattice in the superconducting state of Ta-doped CsV₃Sb₅ with suppressed charge order, suggesting conventional pairing.

Supersymmetric theories have partner bosonic and fermionic particles. Here, the authors use neutron spectroscopy on spin-ladder materials paired with matrix-product-states calculations to identify superpartner excitations.

Despite exhibiting ferroelectric features, SrTiO₃ fails to display long-range polar order at low temperatures due to quantum fluctuations. An ultrafast X-ray diffraction experiment now probes polar dynamics of this material at the nanometre scale.