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This study maps proteomic changes in Alzheimer’s mouse models, identifying shared pathways with humans, amyloid-driven protein turnover, and proteome-transcriptome differences, offering insights into disease mechanisms and potential targets.

The mechanisms allowing early disseminated cancer cells colonize other tissues remain largely unknown. Here, authors show that GPRC5A axis drives esophageal squamous cell carcinoma lung seeding and metastasis, in a mechanism resembling trophoblast behavior during embryo implantation.

Nucleotides are essential for different biological processes and have been also associated to cancer development. Depleting cellular nucleotides is a strategy commonly employed to target cancers. Here, the authors show that purine depletion induces serine synthesis to promote cancer cell migration and metastasis.

Molecular recognition is an important biological process where guest and host molecules interact through non-covalent bonding. Yeet al. show that this can be sensed by the dielectric and ferroelectric signals of the final complexes in a series of metal-coordination compounds with different diol molecules.

Combination of p- and n-doped graphene is important in optoelectronic applications, but spatially selective doping of graphene is challenging. This work reports large-scale growth of graphene monolayers with spatially modulation doping and built-in single-crystalline p–n junctions.

Catalytic asymmetric radical dearomatization has remained a daunting task due to the challenges in exerting stereocontrol over highly reactive radical intermediates. Now, using metalloredox biocatalysis, new-to-nature radical dearomatases P450_rad1–P450_rad5 have been engineered to facilitate asymmetric dearomatization of a broad spectrum of aromatic substrates, including indoles, pyrroles and phenols.

The MAPK pathway is an important therapeutic target in pancreatic ductal adenocarcinoma (PDAC), but success is limited by pathway reactivation, which drives resistance. Here, the authors investigate the mechanism underlying HER2-reactivation post KRAS-MAPK inhibition, identifying combination of MAPK and HER2 inhibition as a therapeutic strategy.

Universal properties have previously been observed mostly in the equilibrium physics of many-body systems in the low-energy and low-temperature regime. Now universality is observed at high temperature in the spin dynamics of a solid-state nuclear magnetic resonance system.

Integrating electrochemical CO electrolysers with a bioreactor can yield high-value long-chain carbon products, but the electrolytes for the two systems are mismatched. Now, a porous solid electrolyte reactor, which can produce acetate directly in bioelectrolyte, is demonstrated. Direct integration with a bioreactor produces bioplastic from CO via the acetate intermediate.

CBF transcription factors facilitate the formation of SKIP nuclear condensates to increase the splicing efficiency of cold-responsive transcripts, bridging transcriptional and post-transcriptional regulation during cold acclimation.

In this phase 3 trial, first-line treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma with anti-PD-1 finotonlimab plus cisplatin plus 5-fluorouracil (C5F) prolonged overall survival compared with placebo plus C5F.

The assembly of the Photosystem II proximal antenna CP47 remains a challenging question. Here the authors show that FPB1 and PAM68 act coordinately with Alb3 and the SecY/E translocon to facilitate the co-translational integration of specific regions of CP47 into thylakoids.

Ancient DNA can reveal evolutionary and demographic history of a region. Here, the authors analyze ancient human DNA from ShanDong, China to reveal two waves of gene flow from Yellow River populations in the DaWenKou (6-4 kBP) and early dynastic (3.5-1.5 kBP) periods.

Ge, Zhou, Fu et al. find caspase-2 accumulates in biomolecular condensates with ubiquitin and proteasomal components and functions as a deubiquitinase following stress. Caspase-2-deficient mice accumulate poly-ubiquitinated TDP-43 and show motor defects.

CD47 blockade can trigger T cell-mediated destruction of immunogenic tumors. Here the authors show that, by reprograming tumor cell metabolism toward OXPHOS for ATP production, tumor cell-intrinsic type I IFN signaling is required for CD47-SIRPa blockade efficacy.

Metabolic reprogramming occurs during tumor progression. Here the authors decipher metabolic trajectories from preneoplasia to lung adenocarcinoma in tumor samples and identify plasma metabolites as potential predictive biomarkers for early detection.

Cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in Chinese Han and white British participants identify autosomal and X-chromosomal associations in more diverse populations.

In a prespecified interim analysis of the randomized, double-blind phase 3 COMPASSION-15 trial, patients with advanced HER2-negative gastric/GEJ cancer treated with the anti-PD-L1/CTLA-4 bispecific Ab cadonilimab plus chemotherapy showed significantly improved overall survival compared with patients treated with placebo plus chemotherapy as first-line treatment.

Traditional N-alkylation methods, especially for α-tertiary amines, suffer from limitations due to high energy barriers from steric hindrance. In this work, the authors leverage visible light irradiation to enable organoboronic acid addition to sterically hindered ketimines using a three-component coupling of aliphatic amines, ortho-phenolic ketones, and organoboronic acids.

In an interim analysis of a phase 1 trial, CAR T cells specific for Claudin18.2, a tight junction protein isoform highly expressed on gastrointestinal tract tumors, were well-tolerated and exhibited promising clinical activity in patients with gastrointestinal cancers.

Photocatalytic water splitting offers a sustainable method for producing green hydrogen but faces challenges due to inefficient materials and systems. Here, the authors report a design for a photocatalytic water-splitting system that efficiently produces hydrogen and oxygen in separate cells.

The advance in improving the operational lifetime of organic solar cells is currently limited. Here, the authors report a radical scavenger capped zinc oxide nanoparticles as the electron transport layer, achieving operationally stable devices with efficiency of 19.47%.

The adaptation to atomically thin 2D semiconductors and van der Waals layered ferroelectrics can enable negative capacitance transistors with superior performance and bendability. Here, the authors report flexible negative capacitance transistors based on MoS2 and a ferroelectric dielectric CIPS with a minimum sub-threshold slope of 28 mV/dec and high gain logic invertors.

Despite the biological importance of sulfones, available synthetic methods usually involve toxic metals and reagents or harsh conditions. Here, the authors report an environmentally benign procedure for the metal-free carbon-sulfur bond formation of allylic sulfones in neutral aqueous medium at room temperature.

c-di-AMP is essential for bacterial signaling. Here, the authors identify the GlcNAc-sensing regulator DasR as a c-di-AMP receptor and provide molecular insight into their signaling effect on the developmental and antibiotic biosynthesis control across Actinobacteria.

The health of brain cells is known to depend on functional autophagy, but the details are unclear. Here, the authors perform systematic proteomic profiling of human and mouse neurons, delineating the landscape of autophagy degradation in brain.

Yang et al. show an age-related increase in the microbial-derived metabolite phenylacetylglutamine that drives host cellular senescence by inducing DNA damage and mitochondrial dysfunction via ADR–AMPK signaling.

The semileptonic decay channels of the Λc baryon can give important insights into weak interaction, but decay into a neutron, positron and electron neutrino has not been reported so far, due to difficulties in the final products’ identification. Here, the BESIII Collaboration reports its observation in e+e- collision data, exploiting machine-learning-based identification techniques.

Topological crystalline insulators are characterized by metallic states originating from crystal symmetries. A transistor device that takes advantage of the quantum properties of the topological crystalline insulating materials SnTe and Pb_1−xSn_xSe(Te) is now proposed.

Xu, Liu, Pen, Zhang et al. demonstrate that the SEL1L–HRD1 complex, which is part of the ERAD protein quality control machinery, safeguards haematopoietic stem cell identity and niche ___location by ensuring the haematopoietic stem cell surface expression of MPL.

Limited whole genome sequencing (WGS) of Asian populations results in a lack of representative reference panels, hindering imputation of Asian ancestry-specific genetic variants. Here the authors use WGS data from 11,067 individuals across 17 Asian countries to create a new reference panel which shows improved imputation accuracy for South Asian populations.

Gold-nanoparticle-coated titania nanowire arrays subretinally implanted in blind mice and monkeys offer advantages in visual acuity and contrast sensitivity towards the restoration of visual function.

The oncoprotein ANLN regulates contractile ring assembly during mitosis, has been reported as an oncoprotein. Here, the authors report a role of nuclear ANLN in gene transcriptional regulation through interaction with RNA Pol II and promoting its clustering and phase separation.

NUPR1 binds to PARP1 and inhibits PARP1 activity in pancreatic cancer cells, with the NUPR1 inhibitor ZZW-115 abolishing the protective effect of NUPR1, inducing strong hyperPARylation and cell death by mitochondrial dysfunction.

In this work, the authors decipher the noncovalent interactions of branching enzymes (BE) with polysaccharides that drive enzyme activity, and report mechanism-guided engineering avenues to promote further development of these industrially important BEs.

By introducing Ni dopants into monolayer Bi₂WO₆, Bi/O frustrated Lewis pairs, unsaturated W atoms, and Ni active units are formed. The authors show that these units facilitate oxygen species transfer and enhance photocatalytic toluene oxidation.

Here, the authors show the emergence of limbic-sensorimotor-association cortical hierarchy along with behavioral development during human infancy is underlaid by the spatiotemporal dynamics of cerebral blood flow meeting brain energy change demand.

In this study, the authors report that, developed economies allocate metal-intensive-low value-added production activities to developing economies in global renewable power value chains. It necessitates building metal-efficient and green supply chains for just transition of power sector.