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Showing 1–50 of 4595 results
Advanced filters: Author: Peng R. Chen Clear advanced filters
  • Previous ophthalmic foundation models have struggled to generalize effectively to diverse and rare fundus diseases, restricting their clinical applicability. Here, the authors introduce a vision-language foundation model that demonstrates superior performance in diagnosing both common and rare fundus conditions.

    • Meng Wang
    • Tian Lin
    • Huazhu Fu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • Gastric Squamous Cell Carcinoma (GSCC) is a rare subtype of gastric cancer with unknown etiology. Here, the authors identify frequent mutations in epigenetic regulation genes including EZH2 in twenty GSCC patient samples, and demonstrate that EZH2 loss, along with TP53 and PTEN loss, leads to GSCC in mouse models.

    • Mengsha Zhang
    • Ailing Zhong
    • Chong Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Few-layer-thick 2D materials offer desirable electronic, thermal and mechanical properties, but their large-scale layer-controlled synthesis is still challenging. Here, the authors report an edge-feeding synchronous epitaxial growth method to synthesize homogeneous A3-sized graphene films with controlled thickness between 2 and 7 layers.

    • Buhang Chen
    • Xiongzhi Zeng
    • Zhongfan Liu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Super spreading events are considered important contributors to the spread of COVID−19, but the extent to which superspreading varies by transmission setting is unclear. Here, the authors demonstrate heterogeneity in superspreading and the generation interval between COVID−19 cases in different settings using data from Hong Kong.

    • Dongxuan Chen
    • Dillon C. Adam
    • Sheikh Taslim Ali
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11
  • Living biophotovoltaics generate bioelectricity by harnessing photosynthetic microorganisms, but barriers to electron transfer across the abiotic/biotic interface hinder solar-to-electricity conversion. Here, the authors report a method for boosting photocurrent by integrating the photosynthetic cyanobacteria with a conductive conjugated polyelectrolyte to form 3D living biocomposites.

    • Zhongxin Chen
    • Samantha R. McCuskey
    • Guillermo C. Bazan
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Neural circuit mechanisms that regulate the panic-like defensive state are not fully understood. Using a robot-based experimental paradigm, the authors identify Cbln2-expressing (Cbln2+) neurons in the mouse posterior hypothalamic nucleus (PHN) as a key neuronal population essential for the induction of panic-like defensive state.

    • Miao Zhao
    • Li Zhang
    • Peng Cao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Generalizable prediction of RNA secondary structure remains a challenge on unseen families. Here, the authors propose BPfold, which integrates a base pair motif library with thermodynamic energy into a deep learning framework, gaining superior accuracy and robustness over state-of-the-art methods.

    • Heqin Zhu
    • Fenghe Tang
    • S. Kevin Zhou
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • The role of vascular plasticity in brain function remains poorly understood. Here, the authors demonstrate that a significant portion of blood vessels in the adult brain periodically occlude and regress, a process that is associated with a reduction in neuronal activity.

    • Xiaofei Gao
    • Xing-jun Chen
    • Woo-ping Ge
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18
  • Regulation of aggregation by light is a useful phenomenon, but the role of the solvent is not often considered. Here, the authors report the development of photoinduced hydrous organic aggregates, emissive in the presence of both water and photoirradiation.

    • Zeyang Ding
    • Rufan Mo
    • Ben Zhong Tang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • In large prospectively enrolled validation cohorts of patients with cancer and controls and a prospective study of asymptomatic individuals with average risk for cancer, a multicancer early detection test based on plasma cell-free DNA genomics and fragmentomics showed encouraging accuracy in identifying ongoing disease as well as the tissue of origin.

    • Hua Bao
    • Shanshan Yang
    • Yang Shao
    Research
    Nature Medicine
    P: 1-9
  • Inactivating PPP2R1A mutations correlate with better survival after immune checkpoint blockade in patients with ovarian clear cell carcinoma, suggesting that targeting the phosphatase 2A (PP2A) pathway may represent an effective startegy for improving responses to immunotherapy.

    • Yibo Dai
    • Anne Knisely
    • Amir A. Jazaeri
    ResearchOpen Access
    Nature
    P: 1-10
  • Nanoplastics (NPs) threaten water safety as conventional coagulants fail to remove them. Here, authors develop an in-situ Fe(III) method that forms encapsulating nanosheets, enabling efficient NP removal with stronger anti-interference in natural waters.

    • Bingqian Yang
    • Long Tian
    • Wenzheng Yu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Prions are infectious agents that initiate transmissible spongiform encephalopathies. The study demonstrates that Prion proteins lower cellular oxidative stress via GPX8, remodel membrane lipids, and together with RAC3, sensitize cells to ferroptotic death, highlighting new therapeutic targets in prion diseases.

    • Hao Peng
    • Susanne Pfeiffer
    • Joel A. Schick
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • Transition metal compounds provide a versatile platform for tailoring Mott physics. Here, the authors reveal that hybridization between the lower Hubbard band and the chalcogen band stabilizes the Mott state through bandwidth tuning in the 1T-MX2 (M = Nb, Ta; X = S, Se) family.

    • Qiang Gao
    • Haiyang Chen
    • Peng Chen
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-6
  • Most studies on the potential of meat alternatives to mitigate environmental pollution look at greenhouse gas emissions, but groundwater quality remains understudied. Using a groundwater nitrate pollution risk assessment model, this study estimates the benefits of a shift away from beef, poultry and pork in the USA over 1985–2020.

    • Yang Zhan
    • Zhilin Guo
    • Chunmiao Zheng
    Research
    Nature Food
    P: 1-12
  • Here the authors report asperigimycins, fungal ribosomally synthesized and post-translationally modified peptides with a heptacyclic scaffold. After chemically modifying them for nanomolar anticancer activity, CRISPR screening identifies SLC46A3 as a key transporter for their uptake in cells.

    • Qiuyue Nie
    • Fanglong Zhao
    • Xue Gao
    Research
    Nature Chemical Biology
    P: 1-10
  • Indian dwarf wheat (Triticum sphaerococcum) is thermotolerant, but the underlying mechanism is unclear. Here, the authors report the cloning of the heat tolerance gene encoding a STKc_GSK3 kinase and its variation affects phosphorylation level of downstream TaPIF4 in determining thermotolerance.

    • Jie Cao
    • Zhen Qin
    • Mingming Xin
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12
  • Understanding how copper nanoparticles evolve under electrochemical conditions is crucial for the development of selective CO2 reduction electrocatalysts. Here the authors prepare well-defined nanocrystals and use advanced operando imaging and spectroscopic techniques to reveal the Cu–CO species-driven dynamic evolution of Cu electrodes.

    • Yao Yang
    • Julian Feijóo
    • Peidong Yang
    Research
    Nature Catalysis
    Volume: 8, P: 579-594
  • Neural networks fundamentally dictate function. Here, the authors show thirteen uniquely connected neuron populations within the anterior thalamic nuclei, suggesting multiple parallel subnetworks support its emotional and cognitive functions.

    • Houri Hintiryan
    • Mitchell Rudd
    • Hong-Wei Dong
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-26
  • Oxidized mitochondrial DNA can be released into cytoplasm activating the Nlrp3 inflammasome resulting in its extracellular release. Here the authors show that only this oxidized form can induce autoantibody production by uptake into plasmacytoid dendritic cells, which then produce interleukin-21 to differentiate naive T cells into TFH cells.

    • Hongxu Xian
    • Kosuke Watari
    • Michael Karin
    Research
    Nature Immunology
    Volume: 26, P: 1168-1181
  • Phytochrome photoreceptors are master regulators of plant development. This paper describes 3D structures of soybean phytochrome A in both Pr (inactive) and Pfr (signalling) states, revealing changes that might transmit the light signal to the cell.

    • Soshichiro Nagano
    • David von Stetten
    • Jon Hughes
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial signaling, paranodal architecture and amyloid-β aggregation are altered in AD, implicating myelin–axon disruption in disease progression.

    • Yifei Cai
    • Iguaracy Pinheiro-de-Sousa
    • Jaime Grutzendler
    Research
    Nature Neuroscience
    P: 1-18
  • Low glume coverage is the preferred for easy threshing in grain production, but the genetic basis remains unclear. Here, the authors report the gene GC1, which encodes an atypical G protein γ subunit, negatively regulates sorghum glume coverage and the naturally truncated alleles can be useful in the naked grain breeding.

    • Peng Xie
    • Sanyuan Tang
    • Qi Xie
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13
  • An RNA codon-expansion strategy enables incorporation of non-canonical amino acids into proteins of interest orthogonally to existing methods by inserting pseudouridine codons into specific mRNA transcripts and using an engineered decoder tRNA.

    • Jiangle Liu
    • Xueqing Yan
    • Peng R. Chen
    Research
    Nature
    P: 1-11
  • Infective endocarditis lacks biomarkers for early diagnosis and personalized care. Here, the authors show proteomic characteristics of plasma and vegetation linked to disease progression, identifying diagnostic and prognostic biomarkers like LRG1 and ADIPOQ, and therapeutic targets like neutrophil traps.

    • Shiman He
    • Xuejiao Hu
    • Bing Gu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21
  • While Bell inequalities have been violated several times—mostly in photonic systems—their violations within particle physics experiments are less explored. Here, the BESIII Collaboration showcases Bell-violating nonlocal correlations between entangled hyperon pairs.

    • M. Ablikim
    • M. N. Achasov
    • J. Zu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9
  • The Dark sectioning algorithm removes the background and provides single-frame optical sectioning in fluorescence microscopy. It offers improved quantitative analysis and deep-tissue segmentation accuracy and is compatible to diverse modalities.

    • Ruijie Cao
    • Yaning Li
    • Peng Xi
    Research
    Nature Methods
    Volume: 22, P: 1299-1310
  • T cell responses can be generated to either pathogen infection or from priming with a vaccine. Here the authors compare T cell generation, phenotype and single cell transcriptome of participants vaccinated with a mpox vaccine or infected with the virus showing that the virus induced T cells showed more effective function and phenotype.

    • Ji-Li Chen
    • Beibei Wang
    • Tao Dong
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17
  • A suite of bridged rhodamine dyes (BriDyes) offers excellent brightness, solubility, photostability, and tunable cell permeability along with resistance to photoblueing, making them exceptional all-purpose dyes for fluorescence biomaging.

    • Junwei Zhang
    • Kecheng Zhang
    • Zhixing Chen
    Research
    Nature Methods
    Volume: 22, P: 1276-1287
  • Three-dimensional (3D) reconstruction from computed tomography could significantly contribute to guiding lung cancer surgery, but requires comprehensive clinical validation. Here, the authors test the effectiveness of an AI-driven 3D reconstruction system for lung cancer surgery in a retrospective, multi-center, multi-reader, multi-case study.

    • Xiuyuan Chen
    • Chenyang Dai
    • Fan Yang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • Tu et al. find inequalities in access to economic, social and environmental infrastructure across 166 countries. Regional disparities and their association with health outcomes underscore the need for equitable infrastructure development.

    • Ying Tu
    • Bin Chen
    • Bing Xu
    ResearchOpen Access
    Nature Human Behaviour
    P: 1-14
  • AI applications on mobile devices are constrained by the high resource demands of large models. Here, the authors developed an efficient on-device multimodal embedding system.

    • Dongqi Cai
    • Shangguang Wang
    • Mengwei Xu
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • Selecting the appropriate Cas12a among the many orthologs for a given target sequence remains difficult. Here, Peng Chen et al. evaluate the activity and specificity of Cas12a variants and facilitate the selection of guide RNA and appropriate Cas12a candidates for gene editing.

    • Peng Chen
    • Yankang Wu
    • Lei Yin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13