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Rehmannia chingii is a traditional Chinese medicinal plant that can produce iridoid glycoside. Here, the authors report its genome assembly and the elucidation of the iridoid biosynthetic pathway.

Colored functional layers are transformed into imperceptible functional meshes. In doing so, various see-through devices are no longer susceptible to the color or opacity of the functional materials and have enhanced transparency.

Type I-E CRISPR–Cas system is one of the most extensively studied RNA-guided adaptive immune systems in prokaryotes. Here, The authors present structures of the Candidatus Cloacimonetes Cas5-HNH/Cascade, with insights into the assembly and activation of this complex.

Zong et al. reveal that genetic and pharmacologic inhibition of TRPM7 channel function prevents the activation of Ca²⁺–CaM–calcineurin–KLF4 signaling, the phenotypic switch of vascular smooth muscle cells and the formation of abdominal aortic aneurysms.

Histidine 73 methylation in β-actin modulates actin plasticity, affecting monomer dynamics and filament stability. Using molecular dynamics simulations, the study reveals that methylation influences nucleotide binding cleft opening and phosphate release.

The authors showcase a method to design negative lumped elements by engineering the effective permittivity within the waveguide, which enables realizations of wideband waveguide metatronics and promises performance enhancement in various fields.

The interplay of magnetism, various symmetries and correlations can lead to intriguing physics in the solid state. Here, the authors report signatures of a Hund nodal line in the antiferromagnet YMn₂Ge₂.

Lymphatic vessels are vital in the musculoskeletal system, but their role in bone repair is unclear. Here the authors found early lymphatic drainage insufficiency in fractures impacts osteoblast survival and stem cell proliferation by modulating the hematoma niche via DAMP transport.

Aqueous zinc batteries attract interest because of their potential for cost-effective and safe electricity storage. Here, the authors develop an in situ formed ion-oligomer nanometric interphase strategy to enable fast-charge aqueous Zn cells.

Glacial-interglacial cycles drove lithium-rich brine formation in the Qarhan Salt Lake in China, according to Th dating and fluid inclusion analyses in halite, and paleotemperature reconstructions.

A brain-cell atlas of a web-building spider and genomic comparisons between web-building and burrowing species identifies preserved ancestral neuron types and candidate neuronal genes that may be involved in the learning and memory pathways underlying web-building and hunting behaviours.

While the high concentration of CO₂ in flue gas makes it an attractive feedstock for electrocatalytic production of useful molecules, SO₂ contaminants can poison catalysts. Here the authors report a polymer/catalyst/ionomer heterojunction design with hydrophobic and hydrophilic domains that improves the SO₂ tolerance of a Cu catalyst.

A reconfigurable metamaterial processing unit that solves arbitrary linear calculus equations is proposed. With the merits of compactness, reconfigurability, and reusability, the proposed MPU provides a potential route for high speed computing.

The central circadian circuit’s role in integrating temperature changes is not fully understood. Here, the authors demonstrate that temperature-sensitive DN1a circadian neurons in the Drosophila brain bidirectionally influence downstream circadian neurons, regulating temperature-dependent physiological activities.

“The interface mismatch of soft substrates and rigid silicon-based microelectronics frequently causes failures of integrated circuits. Here, the authors develop a stretchable solder based on liquid metal-polymer composites which enables seamless integration of electronic components with soft substrates, showcasing high conductivity and stretchability”.

The development of selective ClpP activators targeting only the MRSA isolates without interfering with the human variant is currently challenging. Here, the authors report on the structure-based design of enantiomers of ZG197 and identify the discriminator factor between the proteins.

Copper electrocatalysts enable carbon dioxide/carbon monoxide reduction but suffer from low production rates. Here, the authors promote in situ growth of Cu(100) during electrolysis, enabling efficient and stable electrosynthesis of multicarbon products at industrially-relevant current densities

SOSS–INTAC stimulates promoter-proximal termination of transcription and attenuates R-loops associated with paused RNA polymerase II to prevent R-loop-induced genome instability.

Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. Here, the authors develop a potent activator ZK53 that is highly selective on human ClpP but inactive toward bacterial ClpP proteins, and show that ZK53 causes cell cycle arrest via ClpP on lung squamous cell carcinoma cells and exhibits therapeutic effects in animal models.

The ERK signalling pathway is activated in many cancers, however ERK1 and ERK2 are difficult to target pharmacologically. Here, the authors identify a small molecule inhibitor that binds covalently to the D-recruitment site of ERK and induces cell death and reduces tumour growth in mice.

Chlorine incorporation into CH₃NH₃PbI₃improves solar cell performance, but its optoelectronic role is still unclear. Here the authors present a strategy that decouples the morphological impact, to reveal that chlorine incorporation affects carrier transport across the heterojunction interface rather than within the perovskite crystal.

Pseudomonas aeruginosa quorum-sensing signal N-(3-oxo-dodecanoyl) homoserine lactone alters host cell membranes and induces host cell death via ligand-independent immune receptor ligation.

Hepatocytes are highly specialized cells and their fate is determined by their position in the liver as either periportal or perivenous hepatocytes. Here, Pu et al. show through genetic lineage tracing for Mfsd2 that periportal hepatocytes proliferate and reprogram into pericentral hepatocytes during liver regeneration and injury.

Utilizing mixed-cation-halide can improve stability of the formamidinium perovskite films and devices but sacrifices the photocurrent due to an increase in bandgap. Here Lee et al. introduced small amounts of 2D perovskite to obtain high efficiency and stability based on phase-pure formamidinium based perovskite.

The deconfined quantum critical point describing a continuous phase transition from a plaquette-singlet to an antiferromagnetic Néel phase in SrCu₂(BO₃)₂ has remained elusive. Here, the authors conduct high-pressure heat capacity measurements on the material providing experimental evidence indicating a first-order quantum phase transition between the two different symmetry-breaking phases.

Hypocrystalline ceramic aerogels with a zig-zag architecture show high thermal stability under thermal shock and exposure to high temperature, providing a reliable material system for thermal insulation at extreme conditions.

Perylenediimide (PDI) radical anions show promise as photothermal agents for phototherapy, but are typically very unstable. Here the authors fabricate a PDI-based metal-organic framework where the PDI units become stable radical anions upon incorporation of amine vapors.

Accurate NMR shift prediction using machine learning allows researchers to validate structures by comparing predicted and observed shifts, but predicting 2D NMR remains challenging due to limited annotated data. Here, the authors introduce an unsupervised training framework for predicting and annotating cross-peaks in 2D NMR considering solvent effect, specifically Heteronuclear Single Quantum Coherence (HSQC), showing a MAE of 2.05 ppm for ¹³C and 0.165 ppm for ¹H, and achieving 95.21% concordance with experts’ assignments.

Here the cis form of tau protein, which disrupts axonal microtubules and transport, spreads to other neurons, and leads to apoptosis in vitro and in vivo, is found to be produced by neurons immediately after traumatic brain injury (TBI); treating TBI mice with cis antibody blocks early production of cis tau, prevents tauopathy and spread and restores brain structural and functional outcomes, and may be further developed to treat TBI and to prevent neurodegeneration after injury.

The developmental Genotype-Tissue Expression (dGTEx) projects will catalogue and integrate gene expression, regulation and genetics data across 120 human donors from birth to adulthood with developmentally matched non-human primates, including 126 rhesus macaques and 72 common marmosets.

dCas9-mediated activation has been verified and widely used in vitro. Here the authors generated a potent in vivo activation platform and applied it to control the transcription of multiple genetic elements in the mammalian brain.