Nature Search

A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands

Xavier Estivill
Martin Farrall
Brandon J. Wainwright
Research01 Apr 1987
Nature

Volume: 326, P: 840-845
Reef fish functional traits evolve fastest at trophic extremes

Large-scale phylogenetic analysis of coral reef fish species shows that functional traits evolve fastest in those at high and low trophic levels with narrow diet breadth.

Samuel R. Borstein
James A. Fordyce
Matthew D. McGee
Research26 Nov 2018
Nature Ecology & Evolution

Volume: 3, P: 191-199
Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs

Azacitidine (AZA) response in myelodysplastic neoplasms is unpredictable. Here, the authors show in a phase 2 trial that while global methylation changes did not differ by response, baseline and initial CpG methylation differences in HSPCs predicted AZA response.

Julie A. I. Thoms
Feng Yan
John E. Pimanda
ResearchOpen Access13 May 2025
Nature Communications

Volume: 16, P: 1-20
Localization of cystic fibrosis locus to human chromosome 7cen–q22

Brandon J. Wainwright
Peter J. Scambler
Robert Williamson
Research28 Nov 1985
Nature

Volume: 318, P: 384-385
Is your phylogeny informative? Measuring the power of comparative methods

Peter Ralph
Graham Coop
Carl Boettiger
ResearchOpen Access26 Sept 2011
Nature Precedings

P: 1
Evolutionary lability of a key innovation spurs rapid diversification

A study shows that the rapid diversification of cichlids in African lakes is driven by their ability to evolve between having simple or complex teeth.

Nick Peoples
Michael D. Burns
Peter C. Wainwright
Research26 Feb 2025
Nature

Volume: 639, P: 962-967
Crustal rejuvenation stabilised Earth’s first cratons

Why Earth’s crust only started becoming widely preserved in the Eoarchaean, 500 Ma after planetary accretion, is poorly understood. Here, the authors document a shift to juvenile magmatic sources in the early Eoarchaean, linking crustal preservation to the formation of stabilising melt-depleted mantle.

Jacob A. Mulder
Oliver Nebel
Timothy J. Ivanic
ResearchOpen Access10 Jun 2021
Nature Communications

Volume: 12, P: 1-7
TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells

Hypomethylating agents (HMAs) are frontline therapy for Myelodysplasia, but their efficacy is limited. Here, the authors show that depleting the dual E3-ligase TOPORS synergizes with HMAs by enhancing DNA damage in leukemia cells, improving survival in mouse models without preventing healthy hematopoiesis.

Peter Truong
Sylvie Shen
John E. Pimanda
ResearchOpen Access28 Aug 2024
Nature Communications

Volume: 15, P: 1-19
A closely linked genetic marker for cystic fibrosis

Ray White
Scott Woodward
George Vande Woude
Research28 Nov 1985
Nature

Volume: 318, P: 382-384
Cardiac myosin binding protein–C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathy

Gisèle Bonne
Lucie Carrier
Ketty Schwartz
Research01 Dec 1995
Nature Genetics

Volume: 11, P: 438-440
Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal ___location

Brigitte Royer-Pokora
Louis M. Kunkel
Stuart H. Orkin
Research03 Jul 1986
Nature

Volume: 322, P: 32-38
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos

Edwina Wright
Murray R. Hargrave
Peter Koopman
Research01 Jan 1995
Nature Genetics

Volume: 9, P: 15-20
Role of tissue factor in embryonic blood vessel development

Peter Carmeliet
Nigel Mackman
Désiré Collen
Research05 Sept 1996
Nature

Volume: 383, P: 73-75
A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

Stephen Sawcer
Hywel B. Jones
Alastair Compston
Research01 Aug 1996
Nature Genetics

Volume: 13, P: 464-468
Classical and reverse enetics

Peter N. Goodfellow
News & Views01 Apr 1987
Nature

Volume: 326, P: 824
Prolonged morphological expansion of spiny-rayed fishes following the end-Cretaceous

The authors construct a time-calibrated phylogeny spanning >90% of spiny-rayed fishes to explore patterns of body shape disparity within acanthomorphs. They find a trend of steady accumulation of lineages from the Cenozoic, with an increase in morphological disparity following the Cretaceous–Palaeogene event, facilitating the radiation of diverse morphotypes that characterize acanthomorphs’ widespread ecological success today.

Ava Ghezelayagh
Richard C. Harrington
Thomas J. Near
Research14 Jul 2022
Nature Ecology & Evolution

Volume: 6, P: 1211-1220
Drivers of seedling establishment success in dryland restoration efforts

The seeding of native species is critical to the success of dryland restoration efforts. Here the authors evaluate success of seeding establishment at 174 sites on six continents, finding that some sites had nearly 100% of species successfully recruit, while 17% of sites had zero seedling success.

Nancy Shackelford
Gustavo B. Paterno
Katharine L. Suding
Research22 Jul 2021
Nature Ecology & Evolution

Volume: 5, P: 1283-1290
A synthetic peptide mimic kills Candida albicans and synergistically prevents infection

Fungal infections are severely underestimated as a cause of mortality, and alternative drugs are urgently needed. Here, Schaefer et al. show that a synthetic polymer mimicking defensins shows different, but synergistic activity with known antifungals.

Sebastian Schaefer
Raghav Vij
Sascha Brunke
ResearchOpen Access09 Aug 2024
Nature Communications

Volume: 15, P: 1-22
Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation

The role of actin/tropomyosin filaments in the assembly of cell–substrate adhesions has been investigated and it is now shown by cryo-electron tomography that they are essential for adhesion assembly and also regulate mechanosensing, matrix remodelling and transformation of cells towards a cancer phenotype.

Maria Lastra Cagigas
Nicole S. Bryce
Edna C. Hardeman
Research13 Sept 2021
Nature Materials

Volume: 21, P: 120-128
Germline and somatic mutations in the tyrosine kinase ___domain of the MET proto-oncogene in papillary renal carcinomas

Laura Schmidt
Fuh-Mei Duh
Berton Zbar
Research01 May 1997
Nature Genetics

Volume: 16, P: 68-73
Trophic innovations fuel reef fish diversification

Both geography and ecology can drive the origins of new species. Siqueira et al. show how geological changes in the structure of Miocene reefs and the concurrent evolution of new feeding strategies combine to explain why coral reefs contain such a diversity of fish species.

Alexandre C. Siqueira
Renato A. Morais
Peter F. Cowman
ResearchOpen Access29 May 2020
Nature Communications

Volume: 11, P: 1-11
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Microspectroscopic visualization of how biochar lifts the soil organic carbon ceiling

A decadal-scale field trial revealed 1.01 Mg of rhizodeposit and necromass C was stored in soil microaggregate and mineral fractions per Mg biochar-C applied. Microspectroscopic analyses visualize mechanisms for this elevated soil C storage ceiling.

Zhe (Han) Weng
Lukas Van Zwieten
Annette Cowie
ResearchOpen Access02 Sept 2022
Nature Communications

Volume: 13, P: 1-12
Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein

Lesley McGregor
Ville Makela
Peter J Scambler
Research25 May 2003
Nature Genetics

Volume: 34, P: 203-208
Germline Elongator mutations in Sonic Hedgehog medulloblastoma

Germline mutations in the Elongator complex gene ELP1 predispose individuals to the development of childhood medulloblastoma.

Sebastian M. Waszak
Giles W, Robinson
Stefan M. Pfister
Research01 Apr 2020
Nature

Volume: 580, P: 396-401
Author Correction: Drivers of seedling establishment success in dryland restoration efforts

Nancy Shackelford
Gustavo B. Paterno
Katharine L. Suding
Amendments and Corrections28 Jul 2021
Nature Ecology & Evolution

Volume: 5, P: 1319
A single-Pt-atom-on-Ru-nanoparticle electrocatalyst for CO-resilient methanol oxidation

PtRu nanoparticles are the state-of-the-art catalysts for methanol electrooxidation—the anodic reaction in direct methanol fuel cells. Now, a method of dispersing single Pt atoms over Ru nanoparticles is presented and monitored in situ, thereby boosting the catalytic performance in the methanol oxidation reaction.

Agus R. Poerwoprajitno
Lucy Gloag
Richard D. Tilley
Research25 Mar 2022
Nature Catalysis

Volume: 5, P: 231-237
Raptorial jaws in the throat help moray eels swallow large prey

Moray eels, despite being rapacious predators, are too long and narrow for conventional fish suction mechanisms to work for ingesting prey. So instead of sucking food down to the pharyngeal jaws, these jaws project forward into the mouth cavity and seize the prey - a remarkable innovation which may have contributed to the success of morays as reef predators.

Rita S. Mehta
Peter C. Wainwright
Research06 Sept 2007
Nature

Volume: 449, P: 79-82
Common variants associated with plasma triglycerides and risk for coronary artery disease

Sekar Kathiresan and colleagues examine 185 common variants using a modified mendelian randomization approach and provide evidence supporting a causal role of triglyceride-rich lipoproteins in the development of coronary artery disease.

Ron Do
Cristen J Willer
Sekar Kathiresan
Research06 Oct 2013
Nature Genetics

Volume: 45, P: 1345-1352
Discovery and refinement of loci associated with lipid levels

Cristen Willer and colleagues report genome-wide association analyses for blood lipid levels in 188,578 individuals. They identify 62 loci newly associated with blood lipid levels, refine the association signals at 12 loci and examine associations with cardiovascular and metabolic traits.

Cristen J Willer
Ellen M Schmidt
Gonçalo R Abecasis
Research06 Oct 2013
Nature Genetics

Volume: 45, P: 1274-1283
Biting disrupts integration to spur skull evolution in eels

Functional integration limits the potential for morphological differences to evolve. Here, the authors show an association between changes in skull morphology and evolutionary integration with feeding behaviour in eels.

David C. Collar
Peter C. Wainwright
Rita S. Mehta
Research17 Nov 2014
Nature Communications

Volume: 5, P: 1-9
Room temperature manipulation of long lifetime spins in metallic-like carbon nanospheres

Electronic decoherence due to spin-orbit and magnetic interactions limits the application of spintronic nanosystems in quantum information processing. Here, the authors report notably long spin-lattice and spin-spin relaxation times of 175 ns at room temperature in carbon nanospheres.

Bálint Náfrádi
Mohammad Choucair
László Forró
ResearchOpen Access18 Jul 2016
Nature Communications

Volume: 7, P: 1-8
Sexual dimorphism and morphological integration in the orchid bee brain

Denise Yamhure-Ramírez
Peter C. Wainwright
Santiago R. Ramírez
ResearchOpen Access14 Mar 2025
Scientific Reports

Volume: 15, P: 1-15
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

Garry Cutting and colleagues report a genome-wide association and linkage study for loci that affect lung disease severity in cystic fibrosis. They identify two loci that influence lung function in individuals with cystic fibrosis.

Fred A Wright
Lisa J Strug
Garry R Cutting
Research22 May 2011
Nature Genetics

Volume: 43, P: 539-546
How warm is too warm for the life cycle of actinopterygian fishes?

Ryosuke Motani
Peter C. Wainwright
ResearchOpen Access13 Jul 2015
Scientific Reports

Volume: 5, P: 1-10
Space and time in visual context

Sensory stimuli are interpreted in light of their spatial and temporal context, which can sometimes lead to visual illusions. Schwartz, Hsu and Dayan consider the possible functional benefits of contextual biases and discuss computational models that may explain why spatial and temporal context effects are so similar.

Odelia Schwartz
Anne Hsu
Peter Dayan
Reviews01 Jul 2007
Nature Reviews Neuroscience

Volume: 8, P: 522-535
International network of cancer genome projects

Thomas J. Hudson (Chairperson)
Warwick Anderson
Huanming Yang
Reviews15 Apr 2010
Nature

Volume: 464, P: 993-998
Environmental selection, rather than neutral processes, best explain regional patterns of diversity in a tropical rainforest fish

Katie Gates
Jonathan Sandoval-Castillo
Luciano B. Beheregaray
ResearchOpen Access30 Mar 2023
Heredity

Volume: 130, P: 368-380
A New Raman Metric for the Characterisation of Graphene oxide and its Derivatives

Alice A. K. King
Benjamin R. Davies
Andrew I. Minett
ResearchOpen Access18 Jan 2016
Scientific Reports

Volume: 6, P: 1-6
Melanoma protective antitumor immunity activated by catalytic DNA

Hong Cai
Eun-Ae Cho
Levon M. Khachigian
Research29 May 2018
Oncogene

Volume: 37, P: 5115-5126
Feeding kinematics of a surgeonfish reveal novel functions and relationships to reef substrata

High-speed video of feeding in a surgeonfish reveals novel functions, and suggests an adaptation to feeding in high flow environments, as well as how fish interact with the substrate

Michalis Mihalitsis
Peter C. Wainwright
ResearchOpen Access03 Jan 2024
Communications Biology

Volume: 7, P: 1-12
Survival of people with cystic fibrosis in Australia

Rasa Ruseckaite
Farhad Salimi
Susannah Ahern
ResearchOpen Access17 Nov 2022
Scientific Reports

Volume: 12, P: 1-9
Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis

Lisa Strug and colleagues report a genome-wide association study for meconium ileus in individuals with cystic fibrosis. Conventional genome-wide approaches identified variants in SLC26A9 and SLC6A14 associated with meconium ileus. The authors also performed a hypothesis-driven genome-wide association study (HD-GWAS) that upweighted 3,814 SNPs within 10 kb of 155 genes expressed in the apical plasma membrane. The HD-GWAS identified variants near SLC9A3 associated with meconium ileus.

Lei Sun
Johanna M Rommens
Lisa J Strug
Research01 Apr 2012
Nature Genetics

Volume: 44, P: 562-569
The effectiveness of dietary intervention in osteoarthritis management: a systematic review and meta-analysis of randomized clinical trials

Sara Asadi
Sara Grafenauer
Belinda J. Parmenter
ReviewsOpen Access28 Apr 2025
European Journal of Clinical Nutrition

P: 1-13
Novel predators emit novel cues: a mechanism for prey naivety towards alien predators

Alexandra J. R. Carthey
Martin P. Bucknall
Peter B. Banks
ResearchOpen Access27 Nov 2017
Scientific Reports

Volume: 7, P: 1-9
Arctic mercury cycling

Mercury is emitted by anthropogenic activities and accumulates in the Arctic. This Review presents a mercury budget for the Arctic, describing fluxes and cycling.

Ashu Dastoor
Hélène Angot
Christian Zdanowicz
Reviews22 Mar 2022
Nature Reviews Earth & Environment

Volume: 3, P: 270-286
Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity

Abrey J. Yeo
Anna Henningham
Martin F. Lavin
ResearchOpen Access22 Feb 2019
Scientific Reports

Volume: 9, P: 1-10
Glutamine addiction promotes glucose oxidation in triple-negative breast cancer

Lake-Ee Quek
Michelle van Geldermalsen
Jeff Holst
ResearchOpen Access18 Jul 2022
Oncogene

Volume: 41, P: 4066-4078
Radiomic phenotyping of the lung parenchyma in a lung cancer screening cohort

Babak Haghighi
Hannah Horng
Despina Kontos
ResearchOpen Access04 Feb 2023
Scientific Reports

Volume: 13, P: 1-9
Identification of protein biomarkers and signaling pathways associated with prostate cancer radioresistance using label-free LC-MS/MS proteomic approach

Lei Chang
Jie Ni
Yong Li
ResearchOpen Access22 Feb 2017
Scientific Reports

Volume: 7, P: 1-15

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